Definition and new approaches to understanding the pathogenesis of Drave syndrome in children

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Abstract

Nowadays, Dravet syndrome is one of the most studied forms of genetic epilepsy. Despite a large number of studies and publications, Dravet syndrome remains a difficult neurological disease to treat. The relationship of epileptogenesis in Dravet syndrome with the activity of sodium channels has been studied, and data on the different effectiveness and ineffectiveness of anticonvulsant drugs with different mechanisms of action have been obtained. Drugs that modify neural transmission, enhance inhibitory transmission, and reduce excitatory transmission, as well as their combination, are more effective. Drugs that reduce the effect of inhibitory transmission (in particular, sodium channel blockers) should not be used. In our opinion, the correct choice of therapy for Dravet syndrome associated with a mutation in the SCN1A gene is possible only from the perspective of understanding the work of neural channels in the brain.

About the authors

A. N. Ulyakov

Svt. Luka’s Institute of Child Neurology and Epilepsy; Russian Children Clinical Hospital – branch of the Pirogov Russian National Research Medical University, Ministry of Health of Russia

Author for correspondence.
Email: arturulyakov@mail.ru
ORCID iD: 0000-0003-3054-7560

Artur N. Ulyakov.

5, 8 Nagornaya St., Troitsk, Moscow 108842; 117 Leninskiy Prospekt, Moscow 119571

Russian Federation

M. Yu. Bobylova

Svt. Luka’s Institute of Child Neurology and Epilepsy

Email: fake@neicon.ru
ORCID iD: 0000-0001-6125-0618

5, 8 Nagornaya St., Troitsk, Moscow 108842

Russian Federation

V. S. Lobanova

Svt. Luka’s Institute of Child Neurology and Epilepsy; Morozov Children’s City Clinical Hospital, Moscow Healthcare Department

Email: fake@neicon.ru
ORCID iD: 0000-0002-3764-2766

5, 8 Nagornaya St., Troitsk, Moscow 108842; 1/9 4-yy Dobryninskiy Pereulok, Moscow 119049

Russian Federation

К. Yu. Мukhin

Svt. Luka’s Institute of Child Neurology and Epilepsy

Email: fake@neicon.ru
ORCID iD: 0000-0001-8855-7740

5, 8 Nagornaya St., Troitsk, Moscow 108842

Russian Federation

O. A. Pylaeva

Svt. Luka’s Institute of Child Neurology and Epilepsy

Email: fake@neicon.ru
ORCID iD: 0000-0001-9050-2036

5, 8 Nagornaya St., Troitsk, Moscow 108842

Russian Federation

I. S. Tishchenko

Svt. Luka’s Institute of Child Neurology and Epilepsy; Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0009-0001-4160-2644

5, 8 Nagornaya St., Troitsk, Moscow 108842; 1 Ostrovityanova St., Moscow 117513

Russian Federation

S. O. Kazakov

Svt. Luka’s Institute of Child Neurology and Epilepsy; Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0009-0007-3232-6733

5, 8 Nagornaya St., Troitsk, Moscow 108842; 1 Ostrovityanova St., Moscow 117513

Russian Federation

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