Differential diagnosis difficulties of focal central nervous system damage  in children (а сlinical case)

E. Yu. Skripchenko; Скрипченко Е. Ю.; A. A. Vilnits; Вильниц А. А.; V. E. Karev; Карев В. Е.; N. V. Skripchenko; Скрипченко Н. В.; A. V. Surovzeva; Суровцева А. В.; E. N. Imyanitov; Имянитов Е. Н.; N. V. Marchenko; Марченко Н. В.; M. A. Buhalko; Бухалко М. А.; E. N. Suspitsin; Суспицын Е. Н.

doi:10.17650/2073-8803-2017-12-4-63-73

Differential diagnosis difficulties of focal central nervous system damage in children (а сlinical case)

Authors: Skripchenko E.Y.¹^,2, Vilnits A.A.³, Karev V.E.³, Skripchenko N.V.¹^,2, Surovzeva A.V.³, Imyanitov E.N.¹^,4, Marchenko N.V.³, Buhalko M.A.³, Suspitsin E.N.¹^,4
Affiliations:
1. Pediatric Research and Clinical Center for Infectious Diseases
2. Saint Petersburg State Pediatric Medical University.
3. Pediatric Research and Clinical Center for Infectious Diseases.
4. N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia.
Issue: Vol 12, No 4 (2017)
Pages: 63-73
Section: CLINICAL OBSERVATIONS
Published: 19.01.2018
URL: https://rjdn.abvpress.ru/jour/article/view/237
DOI: https://doi.org/10.17650/2073-8803-2017-12-4-63-73
ID: 237

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Abstract

Focal central nervous system damage can be a result of infectious process in brain or spinal cord, autoimmune or hypoxic-ischemic process and a relationship of these processes. Difficulties in differential diagnosis of variant pathogenic focuses in central nervous system are related with absence of specific clinical and laboratory data. In such cases brain biopsy can help to make right diagnosis. In this article we characterized diagnostical process in teenage girl with progressive case of acute disseminated encephalomyelitis and vegetative status as complication, though she got large doses of steroids and intravenous immunoglobulins at the disease onset, with positive dynamic as a result of prolonged antiviral therapy. The diagnosis was made only by brain biopsy – we found herpesviral brain damage, further the disease transformed in multiple sclerosis.

Keywords

children, focal central nervous system damage, herpesviruses, acute disseminated encephalomyelitis, multiple sclerosis, demyelinated diseases, magnetic resonance imaging

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