MUTATIONS IN THE ARX GENE: CLINICAL, ELECTROENCEPHALOGRAPHIC AND NEUROIMAGING FEATURES IN 3 PATIENTS

I. V. Ivanova; Иванова И. В.; K. Yu. Mukhin; Мухин К. Ю.; O. A. Pylaeva; Пылаева О. А.; M. Yu. Bobylova; Бобылова М. Ю.; N. E. Kvaskova; Кваскова Н. Е.; A. S. Petrukhin; Петрухин А. С.

doi:10.17650/2073-8803-2017-12-3-58-67

MUTATIONS IN THE ARX GENE: CLINICAL, ELECTROENCEPHALOGRAPHIC AND NEUROIMAGING FEATURES IN 3 PATIENTS

Authors: Ivanova I.V.¹, Mukhin K.Y.¹, Pylaeva O.A.¹, Bobylova M.Y.², Kvaskova N.E.¹, Petrukhin A.S.²
Affiliations:
1. Svt. Luka’s Institute of Child Neurology and Epilepsy
2. Svt. Luka’s Institute of Child and Adult Neurology and Epilepsy
Issue: Vol 12, No 3 (2017)
Pages: 58-67
Section: CLINICAL OBSERVATIONS
Published: 01.12.2017
URL: https://rjdn.abvpress.ru/jour/article/view/228
DOI: https://doi.org/10.17650/2073-8803-2017-12-3-58-67
ID: 228

Cite item

Full Text

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

The Aristaless-related homeobox (ARX) gene is a member of the paired-type homeodomain transcription factor family with critical roles in embryonic development, particularly in the developing brain. Mutations in ARX gene demonstrate striking intra- and interfamilial pleiotropy together with genetic heterogeneity and lead to a broad spectrum of diseases. They give rise to 4 key phenotypic features: a different types of brain malformation, abnormal genitalia, epilepsy and intellectual disability. Authors present 3 clinical cases: a girl with duplication on the short arm of X-chromosome (Xp11.22-p22.33), which include genes ARX and CDKL5; a girl and a boy with a missense mutation in ARX gene that have not been previously described (chrX:25031522C>A), causes the substitution of an amino acid in the 197 protein position (p.Gly197Val, NM_139058.2). All patients suffer from severe epilepsy, that is refractory to antiepileptic drugs, and all of them have different degrees of psychomotor delay. The patients with missense mutation also have movement disorders: stereotypic movements in the girl and choreo athetosis and dystonia in the boy. Electroencephalographic abnormalities have been identified in all patients, and there were not significant abnormalities on magnetic resonance imaging in all cases. The described cases broaden the clinical spectrum of mutations in ARX gene.

Keywords

ARX gene, duplication, missense-mutation, epilepsy, intellectual disability, movement disorders

References

Supplementary files

Supplementary Files

Action

1. JATS XML

Download

Username
Password
Remember me

Forgot password?	Register

Username
Password
Remember me

Forgot password?	Register

MUTATIONS IN THE ARX GENE: CLINICAL, ELECTROENCEPHALOGRAPHIC AND NEUROIMAGING FEATURES IN 3 PATIENTS

Full Text

Abstract

Keywords

About the authors

I. V. Ivanova

K. Yu. Mukhin

O. A. Pylaeva

M. Yu. Bobylova

N. E. Kvaskova

A. S. Petrukhin

References

Supplementary files