Comparative characteristic of laboratory indicators for encephalitis, disseminated encephalomyelitis and multiple sclerosis in children

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E. Y. Skripchenko

Pediatric Research and Clinical Center for Infectious Diseases,
Saint-Petersburg State Pediatric Medical University

Author for correspondence.
Email: wwave@yandex.ru

9 Prof. Popova St., Saint Petersburg 197022; 

2 Litovskaya St., Saint Petersburg 194100

Russian Federation

L. A. Alekseeva

Pediatric Research and Clinical Center for Infectious Diseases

Email: fake@neicon.ru
9 Prof. Popova St., Saint Petersburg 197022 Russian Federation

N. V. Skripchenko

Pediatric Research and Clinical Center for Infectious Diseases,
Saint-Petersburg State Pediatric Medical University

Email: fake@neicon.ru

9 Prof. Popova St., Saint Petersburg 197022:

2 Litovskaya St., Saint Petersburg 194100

Russian Federation

T. V. Bessonova

Pediatric Research and Clinical Center for Infectious Diseases

Email: fake@neicon.ru
9 Prof. Popova St., Saint Petersburg 197022 Russian Federation

References

  1. Alekseeva L.A. Skripchenko N.V., Bessonova T.V. et al. Pathogenetic mechanisms underlying the development of demyelinating diseases of the central nervous system in children. Zhurnal nevrologii i psikhiatrii = Journal of Neurology and Psychiatry 2014;6:37–41. (In Russ.).
  2. Alekseeva L.A., Skripchenko N.V., Bessonova T.V. et al. Markers of neuronal and glial damage in cerebrospinal fluid in children with meningitis. Klinicheskaya laboratornaya diagnostika = Clinical
  3. Zheleznikova G.F., Skripchenko N.V., Alekseeva L.A., Skripchenko E.Yu. Chemokines in the pathogenesis of multiple sclerosis. Rossiyskiy immunologicheskiy zhurnal = Russian Journal of Immunology 2017;11(20):15–29. (In Russ.).
  4. Zheleznikova G.F., Skripchenko N.V., Alekseeva L.A., Skripchenko E.Yu. Cytokines in the pathogenesis of multiple sclerosis. Part I. Cytokines of innate immunity. Tsytokiny i vospalenie = Cytokines and Inflammation 2016;15(2):121–33. (In Russ.).
  5. Nazarov V.D., Lapin S.V., Surkova E.A. et al. Intrathecal synthesis of immunoglobulin free light chains: diagnostic value of its evaluation in multiple sclerosis. Meditsinskaya immunologiya = Medical Immunology 2015;17(3):235–44. (In Russ.).
  6. Skripchenko N.V., Ivanova G.P., Zheleznikova G.F. et al. Pathogenetic aspects of leukoencephalitis and its outcomes in children. Neirokhirurgiya i nevrologiya detskogo vozrasta = Pediatric Neurosurgery and Neurology 2012;2–3(32–33):58–69. (In Russ.).
  7. Skripchenko N.V., Ivanova G.P., Skripchenko E.Yu. et al. Clinical and laboratory differential diagnosis of encephalitis, disseminated encephalomyelitis, and multiple sclerosis in children. Pediatriya = Pediatrics 2017;96(4):34–42. doi: 10.24110/0031403Х-2017-96-4-34-42. (In Russ.).
  8. Totolyan N.A., Gotovchikov A.A., Lapin S.V. et al. Intrathecal synthesis of immunoglobulins in the diagnosis and differential diagnosis of multiple sclerosis. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry 2012;112(9–2):73–86. (In Russ.).
  9. Abdelhak A., Hottenrott T., Mayer C. et al. CSF profile in primary progressive multiple sclerosis: Re-exploring the basics. PLoS One 2017;12(8):e0182647. PMID: 28797088. doi: 10.1371/journal.pone.0182647.
  10. Beseler C., Vollmer T., Graner M., Yu X. The complex relationship between oligoclonal bands, lymphocytes in the cerebrospinal fluid, and immunoglobulin G antibodies in multiple sclerosis: Indication of serum contribution. PLoS One 2017;12(10):e0186842. PMID: 29059249. doi: 10.1371/journal.pone.0186842.
  11. Capodivento G., Visigalli D., Garnero M. et al. Sphingomyelin as a myelin biomarker in CSF of acquired demyelinating neuropathies. Sci Rep 2017;7(1):7831. PMID: 28798317. doi: 10.1038/s4159801708314-1.
  12. Di Pauli F., Gredler V., Kuenz B. et al. Features of intrathecal immunoglobulins in patients with multiple sclerosis. J Neurol Sci 2010;288(1–2):147–50. PMID: 19828154. doi: 10.1016/j.jns.2009.09.016.
  13. Krupp L.B., Tardieu M., Amato M.P. et al. International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions. Mult Scler 2013;19(10):1261–7. PMID: 23572237. doi: 10.1177/1352458513484547.
  14. Reiber H., Teut M., Pohl D. et al. Paediatric and adult multiple sclerosis: age-related differences and time course of the neuroimmunological response in cerebrospinal fluid. Mult Scler 2009;15(12):1466–80. PMID: 19995844. doi: 10.1177/1352458509348418.
  15. Sladkova V., Mares J., Hlustik P. et al. Intrathecal synthesis in particular types of multiple sclerosis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2014;158(1):124–6. PMID: 23073520. doi: 10.5507/bp.2012.054.

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