We performed clinical examination of 60 children and adolescents in remission followed up in Research Institute of Pediatric Oncology and Hematology, N.N. Blokhin National Medical Research Center of Oncology. All patients were found to have complex organic disorders of varying severity, primarily induced by aggressive methods of treatment (such as polychemotherapy, high-dose chemotherapy, and cranial irradiation).

Background. In the pathogenesis of cerebral palsy, the pathology of the proprioceptive modality plays an important role. Proprioceptive correction is an effective method for habilitation of children suffering from this disease. "Stimulation of the feet" is one of the methods of proprioceptive correction. In the process of treatment, pressure is applied to the receptor zones of the feet with pneumatic elements. The pressure is produced in walking mode and simulates the effect of the step on the foot.
Objective: the rehabilitation treatment of children with the consequences of perinatal damage to the central nervous system and various forms of cerebral palsy.
Materials and methods. The results of the rehabilitation treatment of 51 children with the consequences of perinatal damage to the central nervous system in 2 age groups: from 7 months to 1 year and from 1 year to 2 years are described. The average age of children was 1.8 ± 0.054 years, standard deviation 0.385. Among them, 27 (52.9 %) were boys, 24 (47.1 %) girls. The children had various motor dysfunctions. Children with a predominance of spasticity in the muscles of the lower extremities were 70.6 %, children with a predominance of reduced tone in the muscles of the lower extremities were 29.4 %. Rehabilitation treatment was carried out from the simulator of the base load "Сorvit". The course of basic stimulation was 10 procedures lasting from 10 to 15 minutes. The mode of stimulation was selected individually as in the classroom for physiotherapy. The duration and intensity of the pressure on the foot were selected.
Results. As a result of treatment, positive dynamics of motor functions was noted. It was expressed in the normalization of muscle tone and with its decrease, and with an increase. The effect of tonic reflexes decreased. In the older group, normalization of the step structure was revealed. A reliable positive dynamics of speech and mental development was recorded. In children aged 7 months to a year with severe spastic paresis, it was statistically significant (p <0.05).
Conclusions. Support stimulation is an effective and safe method of physical habilitation of children with the effects of perinatal brain lesions and cerebral palsy.

Early infantile epileptic encephalopathies (EIEE) are a group of disorders characterized by pharmacoresistant epileptic seizures manifesting in infancy and leading to psychomotor retardation. The most common genetic variant with X-linked dominant inheritance is type 2 EIEE associated with CDKL5 gene mutations.
We evaluated the prevalence of this type of EIEE among Russian patients (n = 148) with epileptic seizures manifesting in infancy and analyzed their clinical and genetic characteristics. We performed exome sequencing for all patients; 15 (10 %) of them (aged between 2 months and 5 years) were found to have CDKL5 gene mutations and were, therefore, diagnosed with type 2 EIEE.
The results of correlation analysis suggest that the severity of clinical manifestations of type 2 EIEE is largely determined by the location of mutations affecting the function of the protein encoded by this gene. This is important to ensure better understanding of type 2 EIEE etiology and predict it severity in patients with different allelic variants.

Since epilepsy is a chronic disease of the nervous system that requires long-term therapy and regular intake of antiepileptic drugs, good tolerability of therapy is crucial for the quality of life of these patients. The main aim of antiepileptic treatment is the creation of a balance between the efficacy and tolerability of therapy. This literature review analyzes tolerability and safety of antiepileptic therapy. We paid particular attention to valproate, a drug that has been used for the treatment of epilepsy for more than 57 years. Valproate remains a basic drug with high efficacy and well-studied safety and tolerability. This review also covers the problems of epilepsy aggravation in response to some antiepileptic drugs, effects of antiepileptic drugs on cognitive functions, behavior, and mental sphere, as well as the issues of tolerability and safety of antiepileptic drugs in women of reproductive age.