The case of development and epileptic encephalopathy with spike-wave activation in sleep in a boy with Smith–Magenis syndrome

A brief literature review of the rare genetic Smith–Magenis syndrome, which is manifested by mental retardation, dyssomnia, and specific behavioral disorders, is presented. Epilepsy occurs in approximately 50 % of patients. A description of long-term follow-up of a patient with this syndrome and epilepsy in the form of development and epileptic encephalopathy with spike-wave activation in sleep is given. Epilepsy onset was at the age of 5 years with focal, bilateral tonic-clonic seizures and status epilepticus. On the electroencephalogram of nocturnal sleep, spike-wave activity was detected in the centrotemporal regions on both hemispheres, with an index of up to 100 %. The patient was able to choose antiepileptic therapy, a long-term remission was achieved, the seizures were stopped.

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