The hypothesis of the functional disintegration of the brain due to the persistence of benign epileptiform patterns on the electroencephalogram
https://doi.org/10.17650/2073-8803-2021-16-3-34-45
Abstract
In this work, we have analyzed the results of observation of 200 children aged from 3 to 15 years old, who had various neuropsychiatric disorders in combination with benign childhood epileptiform patterns on the electroencephalogram. A hypothesis has been put forward about functional disorders of the developing nervous system with prolonged persistence of benign focal epileptiform discharge of childhood on electroencephalogram, mainly in slow-wave sleep. The possibilities of therapeutic correction of these disorders are discussed.
Supporting agencies: We thank Professor K.Yu. Mukhin for his consultation and editing the article and L.A. Maltseva, chief doctor of Children's Clinical Center for administrative support.
About the Authors
I. A. Sadekov
Children's Clinical Center
Ukraine
Ukraine
Igor A. Sadekov.
1a 8-go Sentyabrya St., Makeevka, Donetsk region, 86100.
A. V. Polyakov
Children's Clinical Center
Ukraine
Ukraine
1a 8-go Sentyabrya St., Makeevka, Donetsk region, 86100.
I. V. Sadekova
Children's Clinical Center
Ukraine
Ukraine
1a 8-go Sentyabrya St., Makeevka, Donetsk region, 86100.
E. A. Tupikina
Children's Clinical Center
Ukraine
Ukraine
1a 8-go Sentyabrya St., Makeevka, Donetsk region, 86100.
V. Yu. Kochmar
Children's Clinical Center
Ukraine
Ukraine
1a 8-go Sentyabrya St., Makeevka, Donetsk region, 86100.
T. V. Termenzhi
Medical Radiation Diagnostics Ltd
Ukraine
Ukraine
3/2 Lebedeva St., Makeevka, Donetsk region, 86126.
References
1. Belousova E.D. Risk factors, treatment strategy, and prognosis of convulsive syndrome and epilepsy in children with cerebral palsy. Summary of thesis ... of doctor of medical sciences. Moscow, 2004. 43 p. (In Russ.).
2. Bleykher V.M., Kruk I.V. Explanatory dictionary of psychiatric terms. Voronezh: NPO “MODEK”, 1995. 640 p. (In Russ.).
3. Borovikov K.S. Focal childhood epilepsy with structural brain changes and benign epileptiform discharges on EEG (FECSBCBEDC): Summary of thesis ... of candidate of medical sciences. Moscow, 2018. (In Russ.).
4. Gastaut A. Dictionary of epilepsy. Part I. Definitions. Geneva: WHO, 1975. P. 63. (In Russ.).
5. Glukhova L.Yu., Mukhin K.Yu. Autistic epileptiform regression and its treatment. In: Autism spectrum disorders: medical and psychological assistance. Lvov: Ms Publishing, 2014. Pp. 106—112. (In Russ.).
6. Ermolenko N.A., Bakhtin I.S., Buchneva I.A. Shall we treat patients with benign epileptiform discharges of childhood without epileptic seizures? Russkiy zhurnal detskoy nevrologii = Russian Journal of Child Neurology 2019;14(1):7-13. (In Russ.) DOI: 10.17650/2073-8803-2019-14-1-7-13.
7. Zenkov L.R. Non-paroxysmal epileptic disorders. Moscow: Medpress-Inform, 2007. 278 p. (In Russ.).
8. Karlov V.A. Epileptic encephalopathy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry 2006;106(2):4-12. (In Russ.).
9. Lebedinskiy V.V. Disorders of mental development in children: training manual for psychology students. Moscow: Publishing center “Akademiya”, 2003. 144 p. (In Russ.).
10. Mukhin K.Yu. Benign epileptiform discharges of childhood and their specificity. In: Epilepsy: atlas of electroclinical diagnosis. Moscow: Alvares Pablishing, 2004. Pp. 277-288. (In Russ.).
11. Mukhin K.Yu. benign epileptiform discharges of childhood and associated conditions. Russkiy zhurnal detskoy nevrologii = Russian Journal of Child Neurology 2018;13(3):7-24. (In Russ.). DOI: 10.17650/2073-88032018-13-3-7-24.
12. Mukhin K.Yu. Cognitive epileptiform disintegration and similar syndromes. In: Epileptic encephalopathies and similar syndromes in children. Moscow: ArtServis Ltd, 2011. Pp. 390-424. (In Russ.).
13. Mukhin K.Y., Glukhova L.Y., Makievskaya E.R. Epilepsy with electrical status epilepticus during slow-wave sleep with a focus on electroencephalographic criteria. Russkiy zhurnal detskoy nevrologii = Russian Journal of Child Neurology 2017;12(1):21-35. (In Russ.). DOI: 10.17650/2073-88032017-12-1-21-35.
14. Mukhin K.Yu., Kuzmich G.V., Balkanskaya S.V. et al. Characteristics of epileptiform activity on EEG in children with periventricular leukomalacia and cerebral palsy in the absence of epilepsy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry 2012:7(2):71-6. (In Russ.).
15. Mukhin K.Yu., Petrukhin A.S., Mironov M.B. et al. Epilepsy with electrical status epilepticus during slow-wave sleep: diagnostic criteria, differential diagnosis and approaches to therapy. Moscow, 2005. 32 p. (In Russ.).
16. Nogovitsyn V.Yu., Nesterovskiy Yu.E., Osipova G.N. et al. Polymorphic electroencephalography patterns of benign epileptiform discharges of childhood. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry 2004;104(10):48-56. (In Russ.).
17. SadekovI.A., Polyakov A.V., Sadekova I.V. et al. Syndromes of behavioral and speech disorders associated with benign epileptiform discharges of childhood on electroencephalogram. Russkiy zhurnal detskoy nevrologii = Russian Journal of Child Neurology 2017;12(1):36-40. (In Russ.). DOI: 10.17650/2073-8803-2017-12-1-36-40.
18. Degen R., Holthausen H., Pieper T. et al. Benign epileptic discharges in patients with lesional partial epilepsies. Pediatr Neurol 1999;20(5):354-9.
19. Doose H., Baier W.K. Benign partial epilepsy and related conditions: multifactorial pathogenesis with hereditary impairment of brain maturation. Eur J Pediatr 1989;149:152-8.
20. Doose H., Neubauer B.A., Petersen B. The concept of hereditary impairment of brain maturation. Epileptic Disord 2000;2(Suppl 1):45-9.
21. Doose H., Neubauer B.A., Carlsson G. Children with benign focal sharp waves in the EEG - developmental disorders and epilepsy. Neuropediatrics 1996;27(5):227-41.
22. Dulac O., Milh M., Holmes G.L. Brain maturation and epilepsy. Handb Clin Neurol 2013;111:441-6.
23. Gastaut Y. Un element deroutant de la semiology electroencephalographique: les points prerolandique sans signification focale. Rev Neurol (Paris) 1952;87:488-90.
24. Mukhin K.Yu., Mironov M.B., Borovikov K.S. et al. Unexpected favorable prognosis in children with focal epilepsy due to perinatal brain damage. Epilepsia 2015;56(Suppl 1):173.
25. Tuchman R. Autistic regression and epilepsy. Fifty years of Landau-Kleffner syndrome. Alden Biesen, Belgium. November, 2-4, 2007.
Review
For citations:
Sadekov I.A., Polyakov A.V., Sadekova I.V., Tupikina E.A., Kochmar V.Yu., Termenzhi T.V. The hypothesis of the functional disintegration of the brain due to the persistence of benign epileptiform patterns on the electroencephalogram. Russian Journal of Child Neurology. 2021;16(3):34-45. (In Russ.) https://doi.org/10.17650/2073-8803-2021-16-3-34-45
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