Современные подходы в лечении синдрома Леннокса–Гасто (обзор литературы)

Синдром Леннокса – Гасто (СЛГ) – эпилептическая энцефалопатия с дебютом в детском возрасте, проявляющаяся частыми полиморфными приступами, включая тонические аксиальные, выраженными когнитивными нарушениями, характерными изменениями на электроэнцефалограмме и резистентностью к терапии. Частота синдрома составляет 4–10 % всех форм эпилепсии у детей. Сложности диагностики и лечения СЛГ связаны с сочетанием в картине заболевания приступов нескольких типов, их резистентностью к медикаментозной терапии, возможной эволюцией клинической картины синдрома с возрастом. Авторы представляют обзор литературы, посвященный основным принципам лечения СЛГ, анализ антиэпилептических препаратов, наиболее часто применяемых при этом заболевании, подробно рассматривают клинические исследования, в которых были получены доказательства эффективности и переносимости антиэпилептических препаратов при данной форме эпилепсии. Статья содержит подробный алгоритм лечения СЛГ, основанный на международных рекомендациях и мнениях экспертов.

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