Preview

Russian Journal of Child Neurology

Advanced search

Neuromyelitis optica spectrum disorder in childhood (a case report)

https://doi.org/10.17650/2073-8803-2017-12-4-56-62

Abstract

Neuromyelitis optica spectrum disorder is an inflammatory demyelinating disease of the central nervous system with selective damage to the optic nerves and spinal cord. The clinical case of a child 11 years old and its course throughout the year, with an onset in the form of an episode of visual impairment with signs of a previously developed partial atrophy of the optic nerves of both eyes and a manifestation of retrobulbar neuritis on the left eye is considered in the article. Repeatedly conducted magnetic resonance examination revealed a pattern of focal lesion of the left and then of the right optic nerve with a violation of the integrity of the blood brain barrier and an extended focus in the structure  of the spinal cord of the cervical spine. The blood test for antibody to aquaporin-4 was positive. Optical coherence tomography revealed decrease in the thickness of the peripapillary fibers of the retina in all quadrants in both eyes, which indicates a partial atrophy of the optic nerves  of both eyes, as a result of repeatedly transferred retrobulbar neuritis in both eyes.

About the Authors

A. S. Kotov
M.F. Vladimirsky Moscow Regional Research Clinical Institute.
Russian Federation
61/2 Shchepkina St., Moscow 129110.


Yu. V. Tokareva
M.F. Vladimirsky Moscow Regional Research Clinical Institute.
Russian Federation
61/2 Shchepkina St., Moscow 129110.


V. N. Lutsik
M.F. Vladimirsky Moscow Regional Research Clinical Institute.
Russian Federation
61/2 Shchepkina St., Moscow 129110.


M. V. Panteleeva
M.F. Vladimirsky Moscow Regional Research Clinical Institute.
Russian Federation
61/2 Shchepkina St., Moscow 129110.


A. V. Shatalin
M.F. Vladimirsky Moscow Regional Research Clinical Institute.
Russian Federation
61/2 Shchepkina St., Moscow 129110.


E. V. Mukhina
M.F. Vladimirsky Moscow Regional Research Clinical Institute.
Russian Federation
61/2 Shchepkina St., Moscow 129110.


M. S. Bunak
M.F. Vladimirsky Moscow Regional Research Clinical Institute.
Russian Federation
61/2 Shchepkina St., Moscow 129110.


O. M. Andryukhina
M.F. Vladimirsky Moscow Regional Research Clinical Institute.
Russian Federation
61/2 Shchepkina St., Moscow 129110.


References

1. Котов А.С., Андрюхина О.М., Матюк Ю.В. и др. Оптический неврит и миелит у подростка: оптикомиелит Девика или рассеянный склероз? Неврологический журнал 2015;20(6):35–40. [Kotov A.S., Andryukhina O.M., Matyuk Yu.V. et al. Optic neuritis and myelitis in an adolescent: optical neuromyelitis or multiple sclerosis? Nevrologicheskiy zhurnal = Neurological Journal 2015;20(6):35–40. (In Russ.)].

2. Луцик В.Н., Котов А.С., Борисова М.Н. и др. Оптикомиелит Девика у ребенка. Неврологический журнал 2017;22(4): 205–10. [Lutsik V.N., Kotov A.S., Borisova M.N. et al. Optical neuromyelitis in a child. Nevrologicheskiy zhurnal = Neurological Journal 2017;22(4):205–10. (In Russ.)].

3. Abboud H., Petrak A., Mealy M. et al. Treatment of acute relapses in neuromyelitis optica: steroids alone versus steroids plus plasma exchange. Mult Scler 2016;22(2):185–92. DOI: 10.1177/1352458515581438.

4. Bizzoco E., Lolli F., Repice A.M. et al. Prevalence of neuromyelitis optica spectrum disorder and phenotype distribution. J Neurol 2009;256(11):1891–8. DOI: 10.1007/s00415-009-5171-x.

5. Coutinho A.E., Chapman K.E. The antiinflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol 2011;335(1):2–13. DOI: 10.1016/j.mce.2010.04.005.

6. Wingerchuk D.M. Neuromyelitis optica spectrum disorders: diagnosis and treatment. J Neuroophthalmol 2011;31(4):292.

7. Jacob A., Matiello M., Weinshenker B.G. et al. Treatment of neuromyelitis optica with mycophenolate mofetil: retrospective analysis of 24 patients. Arch Neurol 2009;66(9):1128–33. DOI: 10.1001/archneurol.2009.175.

8. Jiao Y., Fryer J.P., Lennon V.A. et al. Updated estimate of AQP4-IgG serostatus and disability outcome in neuromyelitis optica. Neurology 2013;81(14):1197–204. DOI: 10.1212/WNL.0b013e3182a6cb5c.

9. Killian J.M., Bressler R.B., Armstrong R.M., Huston D.P. Controlled pilot trial of monthly intravenous cyclophosphamide in multiple sclerosis. Arch Neurol 1988;45(1):27–30. PMID: 3276298.

10. Mandler R.N., Ahmed W., Dencoff J.E. Devic’s neuromyelitis optica: a prospective study of seven patients treated with prednisone and azathioprine. Neurology 1998;51(4):1219–20. PMID: 9781568.

11. Matiello M., Jacob A., Wingerchuk D.M., Weinshenker B.G. Neuromyelitis optica. Curr Opin Neurol 2007;20(3):255–60. DOI: 10.1097/WCO.0b013e32814f1c6b.

12. Oh J., Levy M. Neuromyelitis optica: an antibody-mediated disorder of the central nervous system. Neurol Res Int 2012;2012:460825. DOI: 10.1155/2012/460825.

13. Pandit L. Neuromyelitis optica spectrum disorders: an update. Ann Indian Acad Neurol 2015;18(suppl 1):S11–5. DOI: 10.4103/0972-2327.164816.

14. Sherman E., Han M. Acute and chronic management of neuromyelitis optica spectrum disorder. Curr Treat Options Neurol 2015;17(11):48. DOI: 10.1007/s11940015-0378-x.

15. Wingerchuk D.M., Banwell B., Bennett J.L. et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 2015;85(2):177–89. DOI: 10.1212/WNL.0000000000001729.

16. Wingerchuk D.M. Neuromyelitis optica: effect of gender. J Neurol Sci 2009;286(1–2): 18–23. DOI: 10.1016/j.jns.2009.08.045.

17. Zaffaroni M., Italian Devic’s Study Group. Cerebrospinal fluid findings in Devic’s neuromyelitis optica. Neurol Sci 2004;25(suppl 4):S368–70. PMID: 15727236.


Review

For citations:


Kotov A.S., Tokareva Yu.V., Lutsik V.N., Panteleeva M.V., Shatalin A.V., Mukhina E.V., Bunak M.S., Andryukhina O.M. Neuromyelitis optica spectrum disorder in childhood (a case report). Russian Journal of Child Neurology. 2017;12(4):56-62. (In Russ.) https://doi.org/10.17650/2073-8803-2017-12-4-56-62

Views: 963


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2073-8803 (Print)
ISSN 2412-9178 (Online)