Paroxysmal disorders in children receiving substitution therapy with vitamin B12
https://doi.org/10.17650/2073-8803-2017-12-4-43-49
Abstract
Congenital deficiency of vitamin B12 in children is a frequent metabolic disorder in pediatric practice. The disease has multiple symptoms, including various somatic and nervous manifestations. The main symptom of vitamin B12 deficiency is the regression of psychomotor development with significant trophic impairments and changes in the internal organs. Without substitution therapy with vitamin B12, these children quickly develop irreversible disorders that can lead to death, whereas timely parenteral administration of vitamin B12 can ensure the restoration of the initial development level. We describe a patient aged 1 y. o. 4 months, who was diagnosed with vitamin B12 deficiency anemia and general vitamin B12 deficiency at the age of 8 months; as a result, the child developed various paroxysms that were considered to be epileptic. The patients started to receive vitamin B12 and antiepileptic drugs, which helped to achieve clinical remission with normal psychomotor development.
About the Authors
M. V. Barkhatov
Department of Nervous System Diseases and Medical Rehabilitation, Faculty of General Medicine, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of Russia; Krasnoyarsk Regional Clinical Center of Maternity and Childhood.
Russian Federation
1 Partizana Zheleznyaka St., Krasnoyarsk 660022; 2A Akademika Kirenskogo St., Krasnoyarsk 660074.
Russian Federation
1 Partizana Zheleznyaka St., Krasnoyarsk 660022; 2A Akademika Kirenskogo St., Krasnoyarsk 660074.
S. O. Falaleeva
Krasnoyarsk Regional Clinical Center of Maternity and Childhood; Department of Childhood Diseases, Faculty of Pediatrics, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of Russia.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074; 1 Partizana Zheleznyaka St., Krasnoyarsk 660022.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074; 1 Partizana Zheleznyaka St., Krasnoyarsk 660022.
E. V. Shishkina
Department of Nervous System Diseases and Medical Rehabilitation, Faculty of General Medicine, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of Russia.
Russian Federation
1 Partizana Zheleznyaka St., Krasnoyarsk 660022.
Russian Federation
1 Partizana Zheleznyaka St., Krasnoyarsk 660022.
Yu. E. Denisova
Krasnoyarsk Regional Clinical Center of Maternity and Childhood.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074.
E. V. Borisova
Krasnoyarsk Regional Clinical Center of Maternity and Childhood.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074.
A. I. Krasitskiy
Krasnoyarsk Regional Clinical Center of Maternity and Childhood.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074.
N. Yu. Makarevskaya
Krasnoyarsk Regional Clinical Center of Maternity and Childhood.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074.
Russian Federation
2A Akademika Kirenskogo St., Krasnoyarsk 660074.
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Review
For citations:
Barkhatov M.V., Falaleeva S.O., Shishkina E.V., Denisova Yu.E., Borisova E.V., Krasitskiy A.I., Makarevskaya N.Yu. Paroxysmal disorders in children receiving substitution therapy with vitamin B12. Russian Journal of Child Neurology. 2017;12(4):43-49. (In Russ.) https://doi.org/10.17650/2073-8803-2017-12-4-43-49
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