Paroxysmal disorders in children receiving substitution therapy with vitamin B12

M. V. Barkhatov; Бархатов М. В.; S. O. Falaleeva; Фалалеева С. О.; E. V. Shishkina; Шишкина Е. В.; Yu. E. Denisova; Денисова Ю. Е.; E. V. Borisova; Борисова Е. В.; A. I. Krasitskiy; Красицкий А. И.; N. Yu. Makarevskaya; Макаревская Н. Ю.

doi:10.17650/2073-8803-2017-12-4-43-49

Paroxysmal disorders in children receiving substitution therapy with vitamin B12

Authors: Barkhatov M.V.¹^,2, Falaleeva S.O.³^,4, Shishkina E.V.⁵, Denisova Y.E.², Borisova E.V.², Krasitskiy A.I.², Makarevskaya N.Y.²
Affiliations:
1. Department of Nervous System Diseases and Medical Rehabilitation, Faculty of General Medicine, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of Russia
2. Krasnoyarsk Regional Clinical Center of Maternity and Childhood.
3. Krasnoyarsk Regional Clinical Center of Maternity and Childhood
4. Department of Childhood Diseases, Faculty of Pediatrics, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of Russia.
5. Department of Nervous System Diseases and Medical Rehabilitation, Faculty of General Medicine, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of Russia.
Issue: Vol 12, No 4 (2017)
Pages: 43-49
Section: CLINICAL OBSERVATIONS
Published: 19.01.2018
URL: https://rjdn.abvpress.ru/jour/article/view/234
DOI: https://doi.org/10.17650/2073-8803-2017-12-4-43-49
ID: 234

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Abstract

Congenital deficiency of vitamin B12 in children is a frequent metabolic disorder in pediatric practice. The disease has multiple symptoms, including various somatic and nervous manifestations. The main symptom of vitamin B12 deficiency is the regression of psychomotor development with significant trophic impairments and changes in the internal organs. Without substitution therapy with vitamin B12, these children quickly develop irreversible disorders that can lead to death, whereas timely parenteral administration of vitamin B12 can ensure the restoration of the initial development level. We describe a patient aged 1 y. o. 4 months, who was diagnosed with vitamin B12 deficiency anemia and general vitamin B12 deficiency at the age of 8 months; as a result, the child developed various paroxysms that were considered to be epileptic. The patients started to receive vitamin B12 and antiepileptic drugs, which helped to achieve clinical remission with normal psychomotor development.

Keywords

vitamin B12 deficiency, substitution therapy with vitamin B12, seizures in response to vitamin В12 injections

About the authors

M. V. Barkhatov

Department of Nervous System Diseases and Medical Rehabilitation, Faculty of General Medicine, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of Russia; Krasnoyarsk Regional Clinical Center of Maternity and Childhood.

Author for correspondence.
Email: bmv73@mail.ru
1 Partizana Zheleznyaka St., Krasnoyarsk 660022; 2A Akademika Kirenskogo St., Krasnoyarsk 660074. Russian Federation

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