THE PROBLEMS ASSOCIATED WITH SWITCHING BRAND-NAME ANTIEPILEPTIC DRUGS TO GENERICS: A FOCUS ON TOPAMAX: A REVIEW OF LITERATURE AND A CASE REPORT
https://doi.org/10.17650/2073-8803-2016-11-2-42-51
Abstract
Despite the rather high efficiency of treatment for epilepsy (overall, 65–70 % of patients can achieve remission or show a considerable decrease in the frequency of seizures), there remains a challenge due to the need to use antiepileptic drugs long and regularly: therapy adherence, compliance, treatment tolerability, and impact of therapy on quality of patent’s life. One of the aspects of this problem is a very common tendency to switch brand-name antiepileptic drugs to their generics that are 1ess expensive, but also less predictably effective and tolerable. The authors review the literature on the interchangeability of brand-name and generic drugs and describe their case.
About the Authors
K. Yu. Mukhin
Svt. Luka's Institute of Child Neurology and Epilepsy, Moscow
Russian Federation
Russian Federation
Konstantin Y. Muknin –6 Svetlaya St.,PuchkovoVillage, Pervomayskoe Settlement,Moscow, 143396
O. A. Pylaeva
Svt. Luka's Institute of Child Neurology and Epilepsy, Moscow
Russian Federation
Russian Federation
M. Yu. Bobylova
Svt. Luka's Institute of Child Neurology and Epilepsy, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Mukhin K.Yu., Pylaeva O.A., Bobylova M.Yu. THE PROBLEMS ASSOCIATED WITH SWITCHING BRAND-NAME ANTIEPILEPTIC DRUGS TO GENERICS: A FOCUS ON TOPAMAX: A REVIEW OF LITERATURE AND A CASE REPORT. Russian Journal of Child Neurology. 2016;11(2):42-51. (In Russ.) https://doi.org/10.17650/2073-8803-2016-11-2-42-51
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