Angiocentric glioma: clinical, pathomorphological and neuroradiological features of a rare epileptogenic tumor (a review and clinical case)

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Abstract

Angiocentric glioma is an extremely rare low-grade neuroepithelial tumor introduced into the World Health Organization classification of tumors of the central nervous system in 2007. Microscopically, it is a cluster of monomorphic bipolar cells with a predominant diffuse growth pattern and focal perivascular aggregation of tumor cells around blood vessels, which forms a specific angiocentric pattern. Despite the fact that a little more than 100 cases of detection of angiocentric glioma have been described in the literature, a number of clinical, pathomorphological and radiological criteria specific for this tumor have been identified that are characteristic long-term epilepsy associated tumors. The article presents the experience of complex, interdisciplinary diagnosis of angiocentric glioma in a child with focal structural epilepsy and a review of the literature. It should be noted that this is the first case of describing pathomorphologically confirmed angiocentric glioma on the territory of the Russian Federation.

About the authors

V. S. Khalilov

Federal Research and Clinical Center for Children and Adolescents, Federal Medical and Biological Agency of Russia; Pirogov Russian National Research Medical University, Ministry of Health of Russia

Author for correspondence.
Email: khalilov.mri@gmail.com
ORCID iD: 0000-0001-5696-5029

Varis Sadrutdinovich Khalilov

20 Moskvorechye St., Moscow 115409

1 Ostrovityanova St., 117997 Moscow

Russian Federation

A. N. Kislyakov

Morozov Children’s City Clinical Hospital, Moscow Healthcare Department

Email: fake@neicon.ru
ORCID iD: 0000-0001-8735-4909

1/9 4-yy Dobryninskiy Pereulok, Moscow

Russian Federation

O. A. Ryleva

N.N. Burdenko National Scientific and Practical Center for Neurosurgery, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0009-0005-9466-8929

16, 4-ya Tverskaya-Yamskaya St., Moscow 125047

Russian Federation

N. A. Medvedeva

Federal Research and Clinical Center for Children and Adolescents, Federal Medical and Biological Agency of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: fake@neicon.ru
ORCID iD: 0000-0002-2371-5661

20 Moskvorechye St., Moscow 115409

Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

A. A. Kholin

Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-2379-3739

1 Ostrovityanova St., 117997 Moscow

Russian Federation

References

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