Pharmacoresistant course of idiopathic generalized epilepsy or concomitant pathology: a clinical case

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Abstract

The development of pharmacoresistance in epilepsy in pediatric patients is one of the most pressing problems. For relatively benign forms such as idiopathic generalized epilepsy, drug resistance is not typical. If it occurs in such patients, there is a need for an additional diagnostic search, in which it is possible to identify a double pathology with the presence of a focus of structural damage to the brain involved in epileptogenic processes. The article presents a clinical case of drug-resistant childhood absence epilepsy in a patient with combined pathology.

About the authors

A. I. Paramonova

Voino-Yasenetsky Krasnoyarsk State Medical University

Author for correspondence.
Email: korolek_xd@bk.ru
ORCID iD: 0000-0002-9394-2413

Anastasiya I. Paramonova.

1 Partizana Zheleznyaka St., Krasnoyarsk 660022

Russian Federation

I. M. Demyanova

Krasnoyarsk Regional Clinical Center of Maternal and Child Health

Email: fake@neicon.ru
ORCID iD: 0000-0002-6283-0099

2A Akademika Kirenskogo St., Krasnoyarsk 660074

Russian Federation

A. A. Vasilyeva

Voino-Yasenetsky Krasnoyarsk State Medical University

Email: fake@neicon.ru
ORCID iD: 0009-0008-3369-1537

1 Partizana Zheleznyaka St., Krasnoyarsk 660022

Russian Federation

A. V. Palachanina

Voino-Yasenetsky Krasnoyarsk State Medical University

Email: fake@neicon.ru

1 Partizana Zheleznyaka St., Krasnoyarsk 660022

Russian Federation

D. V. Dmitrenko

Voino-Yasenetsky Krasnoyarsk State Medical University

Email: fake@neicon.ru
ORCID iD: 0000-0003-4639-6365

1 Partizana Zheleznyaka St., Krasnoyarsk 660022

Russian Federation

References

  1. Blinov D.V. Epilepsy syndromes: the 2022 ILAE definition and classification. Epilepsiya i paroksizmalnye sostoyaniya = Epilepsy and Paroxysmal Conditions 2022;(14):101–82. (In Russ.). doi: 10.17749/2077-8333/EPI.PAR.CON.2022.123
  2. Paramonova A.I., Lysova K.D., Timechko E.E. et al. Cognitive impairment in childhood-onset epilepsy. Epilepsiya i paroksizmalnye sostoyaniya = Epilepsy and Paroxysmal Conditions 2024;(16):54–68. (In Russ.). doi: 10.17749/2077-8333/EPI.PAR.CON.2024.176
  3. Abou El Ella S.S., Tawfik M.A., Abo El Fotoh W.M.M. et al. The genetic variant “C588T” of GABARG2 is linked to childhood idiopathic generalized epilepsy and resistance to antiepileptic drugs. Seizure 2018;(60):39–43. doi: 10.1016/J.SEIZURE.2018.06.004
  4. Asadi-Pooya A.A., Sperling M.R. Age at onset in patients with medically refractory temporal lobe epilepsy and mesial temporal sclerosis: Impact on clinical manifestations and postsurgical outcome. Seizure 2015;(30):42–5. doi: 10.1016/J.SEIZURE.2015.05.015
  5. Avalos J.C., Sánchez F., Rosso B. et al. Cerebral structural changes in generalized idiopathic epilepsy identified by automated magnetic resonance imaging analysis. Medicina (B Aires) 2019;(79):111–4.
  6. Caciagli L., Wandschneider B., Xiao F. et al. Abnormal hippocampal structure and function in juvenile myoclonic epilepsy and unaffected siblings. Brain 2019;(142):2670–87. doi: 10.1093/BRAIN/AWZ215
  7. Gesche J., Beier C.P. Drug resistance in idiopathic generalized epilepsies: Evidence and concepts. Epilepsia 2022;(63):3007–19. doi: 10.1111/EPI.17410
  8. Gomez-Ibañez A., McLachlan R.S., Mirsattari S.M. et al. Prognostic factors in patients with refractory idiopathic generalized epilepsy. Epilepsy Res 2017;(130):69–73. doi: 10.1016/J.EPLEPSYRES.2017.01.011
  9. Gregorčič S., Hrovat J., Bizjak N. et al. Difficult to treat absence seizures in children: A single-center retrospective study. Front Neurol 2022;(13):958369. doi: 10.3389/FNEUR.2022.958369/BIBTEX
  10. Guerrini R., Marini C., Barba C. Generalized epilepsies. Handb Clin Neurol 2019;(161):3–15. doi: 10.1016/B978-0-444-64142-7.00038-2
  11. Harvey S., Thompson C., O’Flaherty O. et al. Relationship between electroencephalography and seizure outcome in typical absence seizures in children. Pediatr Neurol 2023;(148):56–64. doi: 10.1016/J.PEDIATRNEUROL.2023.08.004
  12. Hirsch E., French J., Scheffer I.E. et al. ILAE definition of the idiopathic generalized epilepsy syndromes: Position statement by the ILAE Task Force on nosology and definitions. Epilepsia 2022;(63):1475–99. doi: 10.1111/EPI.17236
  13. Jain P. Absence seizures in children: Usual and the unusual. Indian J Pediatr 2020;(87):1047–56. doi: 10.1007/S12098-020-03423-8/TABLES/4
  14. Jiang T., Zhang X., Zhang M. et al. Drug-resistant idiopathic generalized epilepsy: A meta-analysis of prevalence and risk factors. Epilepsy Behav 2023;(146):109364. doi: 10.1016/J.YEBEH.2023.109364
  15. Kalilani L., Sun X., Pelgrims B. et al. The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis. Epilepsia 2018;(59):2179–93. doi: 10.1111/EPI.14596
  16. Le Roux M., Benallegue N., Gueden S. et al. Care of pharmaco-resistant absence seizures in childhood. Rev Neurol (Paris) 2024;(180):251–5. doi: 10.1016/J.NEUROL.2024.01.002
  17. Löscher W., Potschka H., Sisodiya S.M., Vezzani A. Drug resistance in epilepsy: Clinical impact, potential mechanisms, and new innovative treatment options. Pharmacol Rev 2020;(72):606. doi: 10.1124/PR.120.019539
  18. Mehvari Habibabadi J., Badihian S., Tabrizi N. et al. Evaluation of dual pathology among drug-resistant epileptic patients with hippocampal sclerosis. Neurol Sci 2019;(40):495–502. doi: 10.1007/S10072-018-3677-7/TABLES/3
  19. Nuyts S., D’Souza W., Bowden S.C., Vogrin S.J. Structural brain abnormalities in genetic generalized epilepsies: A systematic review and meta-analysis. Epilepsia 2017;(58):2025–37. doi: 10.1111/EPI.13928
  20. Rinaldi V.E., Di Cara G., Mencaroni E., Verrotti A. Therapeutic options for childhood absence epilepsy. Pediatric Rep 2021;(13):658–67. doi: 10.3390/PEDIATRIC13040078
  21. Valentin A., Hindocha N., Osei-Lah A. et al. Idiopathic generalized epilepsy with absences: Syndrome classification. Epilepsia 2007;(48):2187–90. doi: 10.1111/J.1528-1167.2007.01226.X
  22. Wang Z., Wang X., Rong R. et al. Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures. Neuroreport 2019;(30):700–6. doi: 10.1097/WNR.0000000000001262
  23. Zhao X., He Z., Li Y. et al. Atypical absence seizures and gene variants: A gene-based review of etiology, electro-clinical features, and associated epilepsy syndrome. Epilepsy Behav 2024;(151):109636. doi: 10.1016/J.YEBEH.2024.109636
  24. Zhou S.Y., Tong L., Song F. et al. Selective medial temporal volume reduction in the hippocampus of patients with idiopathic generalized tonic-clonic seizures. Epilepsy Res 2015;(110):39–48. doi: 10.1016/J.EPLEPSYRES.2014.11.014

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