Metabolic aspects of epilepsy: prospects for metabolome research
https://doi.org/10.17650/2073-8803-2025-20-1-25-31
Abstract
Epilepsy is one of the most common neurological diseases. Despite the availability of modern antiepileptic drugs, up to 30 % of patients fail to achieve control over seizures and develop pharmacoresistancy, which leads to decrease in quality of life, social and professional limitations as well as their stigmatization in society. Epilepsy is closely connected with malfunction of one of the most metabolically active systems of our body – the central nervous system and seizures can be the cause of this metabolic failure as well as its consequence. Metabolomics is a new, rapidly developing scientific area and a promising tool for postgenomic research by studying biological fluids. The study of metabolome is the analysis of the combination of low molecular weight substances (metabolites) of an organism or biological sample, including various substances such as aminoacids, organic acids, sugars, steroids, nucleotides and lipids. This review summarizes the results of studies concerning the role of metabolic disorders in epileptogenesis. The analysis of scientific publications devoted to the assessment of the metabolic profile in epilepsy, the study of its features depending on the phenotype of the disease, and the response to therapy. Probably, further studies of metabolism will allow us to identify new biomarkers that can be used in the process of diagnostic search, in determining the prognosis of the disease and personification of therapy.
About the Authors
D. O. Sigalov
South Ural State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Daniil O. Sigalov - Department of Nervous Diseases.
64 Vorovskogo St., Chelyabinsk 454141
M. I. Karpova
South Ural State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Nervous Diseases.
64 Vorovskogo St., Chelyabinsk 454141
A. F. Dolinina
South Ural State Medical University, Ministry of Health of Russia; Chelyabinsk Regional Children’s Clinical Hospital
Russian Federation
Russian Federation
Department of Nervous Diseases, South Ural State Medical University; Chelyabinsk Regional Children’s Clinical Hospital.
64 Vorovskogo St., Chelyabinsk 454141; 42A Blukhera St., Chelyabinsk 454087
A. I. Sinitskii
South Ural State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Biochemistry named after R.I. Lifshitz.
64 Vorovskogo St., Chelyabinsk 454141, Russia
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Review
For citations:
Sigalov D.O., Karpova M.I., Dolinina A.F., Sinitskii A.I. Metabolic aspects of epilepsy: prospects for metabolome research. Russian Journal of Child Neurology. 2025;20(1):25-31. (In Russ.) https://doi.org/10.17650/2073-8803-2025-20-1-25-31
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