Preview

Russian Journal of Child Neurology

Advanced search

Substantiation of additional diagnostic methods for mental and cognitive disorders in the structure of childhood absence epilepsy

https://doi.org/10.17650/2073-8803-2025-20-1-9-16

Abstract

Background. Childhood absence epilepsy (CAE) is a common form of epilepsy in preschool and primary school children, characterized by absences and pathognomonic electroencephalographic signs. The question regarding the characterization of intelligence remains relevant today – as available data are often contradictory.

Aim. To analyse the data obtained during the study using age-matched questionnaires and tests, to assess the frequency of occurrence and clinical course of cognitive disorders and changes in the emotional-volitional sphere in patients with CAE.

Materials and methods. A total 49 patients diagnosed with DAE were observed, divided into two groups according to age: 1) children 4–10 years old (n = 26); 2) children 11–17 years old (n = 23). 24 healthy children were included in the control group. The methods of assessment used were: test for preschoolers “Numbers”, Stroop test, graphic method of M.A. Panfilova “Cactus”, trail making test, WAM questionnaire (well-being, activity, mood), Eysenck questionnaire, and Achenbach questionnaire.

Results. In group 1 of combined diagnostics compared to the control group there were statistically significant deviations in the study of short-term memory, flexibility of cognitive control and emotional sphere of the child. In group 2 of combined diagnostics higher levels of emotional instability, lower overall well-being, and reduced activity and mood scores were identified. The study of the peculiarities of behaviour deviating from the accepted social norm demonstrates that isolation, somatic problems, socialization disorders, attention problems and the index of internal problems are significantly higher in patients with CAE than in the healthy children.

Conclusion. Children with CAE have a significant risk of developing psychopathologic manifestations compared to the general population. Children with CAE need timely additional diagnostics of higher mental functions, which in turn will improve adaptation to living conditions, education and quality of life.

About the Authors

V. A. Karlov
Russian University of Medicine, Ministry of Health of Russia
Russian Federation

Vladimir A. Karlov - Department of Neurology, Faculty of Medicine, Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko.

4 Dolgorukovskaya St., Moscow 127006



A. A. Dubrovskaya
Moscow Multidisciplinary Clinical Center “Kommunarka”, Moscow Healthcare Department
Russian Federation

8 Sosenskiy Stan St., Moscow 108814



References

1. Karlov V.A. Convulsive and non-convulsive epileptic status. Moscow: MGMSU, 2007. 81 p. (In Russ.).

2. Kissin M.Ya. Clinical epileptology. Moscow: GEOTAR-Media, 2009. 256 р. (In Russ.).

3. Kolyagin V.V. Epilepsy (chronic personality changes, dementia, affective disorders, neuroses, acute and chronic psychoses, diagnosis and treatment; epileptic encephalopathies). Manual for doctors. Irkutsk: State Medical Academy of Postgraduate Education, 2013. 59 p. (In Russ.).

4. Mikhaylov V.A., Gromov S.A., Wasserman L.I. et al. Quality of life and stigmatization of patients with epilepsy. Ed. by N.G. Neznanov. Saint Petersburg, 2010. Pp. 891–936. (In Russ.).

5. Bhise V.V., Burack G.D., Mandelbaum D.E. Baseline cognition, behavior, and motor skills in children with new-onset, idiopathic epilepsy. Dev Med Child Neurol 2010;52:22–6. DOI: 10.1111/j.1469-8749.2009.03404.x

6. Caplan R., Siddarth P., Stahl L. et al. Childhood absence epilepsy: Behavioral, cognitive, and linguistic comorbidities. Epilepsia 2008;49:1838–46. DOI: 10.1111/j.1528-1167.2008.01680.x

7. Cheng D., Yan X., Gao Z. et al. Neurocognitive profiles in childhood absence epilepsy. J Child Neurol 2017; 32:46–52. DOI: 10.1177/0883073816668465

8. Dlugos D., Shinnar S., Cnaan A. et al. Pretreatment EEG in childhood absence epilepsy. Associations with attention and treatment outcome. Neuroljgy 2013;81:150–6. DOI: 10.1212/WNL.0b013e31829a3373

9. Engel J.Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy. Report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001;42:796–803. DOI: 10.1046/j.1528-1157.2001.10401.x

10. Engel J. Report of the ILAE сlassification сore group. Epilepsia 2006;47:1558–68. DOI: 10.1111/j.1528-1167.2006.00215.x

11. Hermann B., Jones J., Dabbs K. et al. The frequency, complications and aetiology of ADHD in new onset paediatric epilepsy. Brain 2007;130:3135–48. DOI: 10.1093/brain/awm227

12. Hommet C., Sauerwein H.C., de Toffol B., Lassonde M. Idiopathic epileptic syndromes and cognition. Neurosci Biobehav Rev 2006;30:85–96. DOI: 10.5505/epilepsi.2014.70894

13. Ijff D.M., Aldenkamp A. Cognitive side effects of antiepileptic drugs in children. Handb Clin Neurol 2013;111:707–18. DOI: 10.1016/B978-0-444-52891-9.00073-7

14. Masur D., Shinnar Sh., Cnaan A. et al. Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy. Neurology 2013;81:1572–80. DOI: 10.1212/WNL.0b013e3182a9f3ca

15. Ratcliffe C., Wandschneider B., Baxendale S. et al. Cognitive function in genetic generalized epilepsies: Insights from neuropsychology and neuroimaging. Front Neurol 2020;11:144. DOI: 10.3389/fneur.2020.00144

16. Shinnar R.C., Shinnar Sh., Cnaan A. et al. Pretreatment behavior and subsequent medication effects in childhood absence epilepsy. Neurology 2017;89:1698–706. DOI: 10.1212/WNL.0000000000004514

17. Striano P., Weber Y.G., Toliat M.R. et al. GLUT1 mutations are a rare cause of familial idiopathic generalized epilepsy. Neurology 2012;78:557–562. DOI: 10.1212/WNL.0b013e318247ff54

18. Suls A., Mullen S.A., Weber Y.G. et al. Early onset absence epilepsy caused by mutations in the glucose transporter GLUT1. Ann Neurol 2009;66:415–9. DOI: 10.1002/ana.21724

19. Vega C., Vestal M., DeSalvo M. et al. Differentiation of attention-related problems in childhood absence epilepsy. Epilepsy Behav 2010;19:82–5. DOI: 10.1016/j.yebeh.2010.06.010


Review

For citations:


Karlov V.A., Dubrovskaya A.A. Substantiation of additional diagnostic methods for mental and cognitive disorders in the structure of childhood absence epilepsy. Russian Journal of Child Neurology. 2025;20(1):9-16. (In Russ.) https://doi.org/10.17650/2073-8803-2025-20-1-9-16

Views: 163


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2073-8803 (Print)
ISSN 2412-9178 (Online)