EARLY ONSET BENIGN CHILDHOOD OCCIPITAL EPILEPSY (PANAYIOTOPOULOS SYNDROME). A CASE REPORT

The childhood epilepsy with occipital paroxysms and early onset or Panayiotopoulos syndrome is a benign focal epileptic syndrome,
a benign disease, developing at infants. The disease has been described in 1989 by S. Panayiotopoulos on the basis of results of own observations, who has called this syndrome “benign night childhood occipital lobe epilepsy”. In 1996 N. Fejerman et al. offered the new name of the syndrome – benign childhood occipital lobe epilepsy, with earlier onset (Panayiotopoulos type), versus the childhood occipital lobe epilepsy, starting later in childhood (Gastaut type). The Panayiotopoulos syndrome occurs only at children, develops at healthy children without neurological disorders, the pick of disease falls on 4–5 years. The morbidity of boys and girls is almost the same. In most cases of the syndrome seizures take place during the sleep, 2 / 3 of patients report seizures only during sleep. As a rule, seizures last for more than 5 min, in 40 % of cases it last for more than 30 min, what corresponds (according to the consciousness level) to focal or generalized epileptic status criteria. To typical clinical syndromes at Panayiotopoulos syndrome are referred the ictal vomiting, as well as different vegetative symptoms. So, theictal vomiting, which, generally, is not typical for epilepsy, takes place in about 80 % of cases at Panaytopululos syndrome. Authors describe their own observation of the Panayiotopoulos syndrome at 5 years old girl.

1. Beaumanoir A. Semiology of occipital seizures in infants and children. In: Occipital Seizures and Epilepsies in Children. F. Andermann, A. Beaumanoir, L. Mira et al. (eds.). London: John Libbey, 1993. Рр. 71–86.

2. Berg A.T., Panayiotopoulos C.P. Diversity in epilepsy and a newly recognized benign childhood syndrome [Editorial]. Neurology 2000;55:1073–4.

3. Caraballo R.H., Cersosimo R., Fejerman N. Idiopathic partial epilepsies with rolandic and occipital spikes appearing in the same children. J Epilepsy 1998;11:261–4.

4. Caraballo R.H., Cersosimo R.O., Medina C.S. et al. Epilepsias parciales idiopáticas con paroxismos occipitales. Rev Neurol 1997;25:1052–8.

5. Caraballo R.H., Cersosimo R., Medina C. et al. Panayiotopoulos-type benign childhood occipital epilepsy: a prospective study. Neurology 2000;55:1096–100.

6. Cooper G.W., Lee S.I. Reactive occipital epileptiform activity: is it benign? Epilepsia 1991;32:63–8.

7. Covanis A., Lada C., Skiadas K. Children with rolandic spikes and ictus emeticus: rolandic epilepsy or Panayiotopoulos syndrome? Epileptic Disord 2003;5:139–43.

8. Covanis A., Ferrie C.D., Koutroumanidis M. et al. Panayiotopoulos syndrome and Gastaut type idiopathic childhood occipital epilepsy. In: Epileptic syndromes in infancy, childhood and adolescence. J. Roger, M. Bureau, Ch. Dravet et al. (eds.). 4th ed. Montrouge, France: John Libbey, 2005. Рр. 227–53.

9. Demirbilek V., Dervent A. Panayiotopoulos syndrome: video-EEG illustration of a typical seizure. Epileptic Disord 2004;6:121–4.

10. Engel J. Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001;42:796–803.

11. Fejerman N. Atypical evolutions of benign partial epilepsies in children. Int Pediatrics 1996;11:351–6.

12. Fejerman N. New idiopathic partial epilepsies. Epilepsia 1997;38 Suppl 7:26.

13. Fejerman N. Benign focal epilepsies in infancy, childhood and adolescence. Rev Neurol 2002;34:7–18.

14. Fejerman N. Epileptic syndromes and diseases. In: Encyclopedia of the Neurological Sciences. M. Aminoff, R.B. Daroff (eds.). San Diego, CA: Academic Press, 2003. Pp. 264–88.

15. Ferrie C.D., Beaumanoir A., Guerrini R. et al. Early-onset benign occipital seizure susceptibility syndrome. Epilepsia 1997;38:285–93.

16. Ferrie C.D., Caraballo R.H., Covanis A. et al. Panayiotopoulos syndrome: a consensus view. Dev Med Child Neurol 2006;48(3): 236–40.

17. Guerrini R., Dravet Ch., Genton P. et al. Idiopathic photosensitive occipital lobe epilepsy. Epilepsia 1995;36:883–91.

18. Kivity S., Lerman P. Stormy onset with prolonged loss of consciousness in benign childhood epilepsy with occipital paroxysms. J Neurol Neurosurg Psychiatr 1992;55:45–8.

19. Kramer U., Nevo Y., Neufeld Y. et al. Epidemiology of epilepsy in childhood: a cohort of 440 consecutive patients. Pediatric Neurol 1998;18(1):46–50.

20. Kuzniecky R., Rosenblatt B. Benign occipital epilepsy: a family study. Epilepsia 1987;28:346–50.

21. Lada C., Skiadas K., Theodorou V. et al. A study of 43 patients with Panayiotopoulos syndrome: a common and benign childhood seizure susceptibility. Epilepsia 2003;44:81–8.

22. Neubauer B.A., Fiedler B., Himmelein B. et al. Centro-temporal spikes in families with Rolandic epilepsy: linkage to chromosome 15q14. Neurology 1998;51:1608–12.

23. Newton R., Aicardi J. Clinical findings in children with occipital spike-wave complexes suppressed by eye-opening. Neurology 1983;33:1526–9.

24. Oguni H., Hayashi K., Imai K. et al. Study on the early-onset variant of benign childhood epilepsy with occipital paroxysms otherwise described as early-onset benign occipital seizure susceptibility syndrome. Epilepsia 1999;40:1020–30.

25. Panayiotopoulos C.P. Inhibitory effect of central vision on occipital lobe seizures. Neurology 1981;31:1330–3.

26. Panayiotopoulos C.P. Vomiting as an ictal manifestation of epileptic seizures and syndromes. J Neurol Neurosurg Psychiatr 1988;51:1448–51.

27. Panayiotopoulos C.P. Benign childhood epilepsy with occipital paroxysms: a 15-year prospective study. Ann Neurol 1989;26:51–6.

28. Panayiotopoulos C.P. Benign nocturnal childhood occipital epilepsy: a new syndrome with nocturnal seizures, tonic deviation of the eyes, and vomiting. J Child Neurol 1989;4: 43–9.

29. Panayiotopoulos C.P. Benign childhood epilepsy with occipital paroxysms. In: Andermann F., Beaumanoir A., Mira L. et al. Occipital seizures and epilepsies in children. London: John Libbey, 1993. Pp. 151–64.

30. Panayiotopoulos C.P. Benign childhood partial seizures and related epileptic syndromes. London: John Libbey, 1999.

31. Panayiotopoulos C.P. Elementary visual hallucinations, blindness, and headache in idiopathic occipital epilepsy: differentiation from migraine. J Neurol Neurosurg Psychiatry 1999;66:536–40.

32. Panayiotopoulos C.P. Panayiotopoulos syndrome: a common and benign childhood epileptic syndrome. London: John Libbey, 2002.

33. Panayiotopoulos C.P. Early onset benign childhood occipital epilepsy (Panayiotopoulos syndrome). In: MedLink Neurology (Section of Epilepsy). J. Engel, N. Fejerman (eds.). San Diego, CA: MedLink, 1999. Рр. 2005. Available: www.medlink.com.

34. Panayiotopoulos C.P. Benign childhood focal seizures and related epileptic syndromes.In: Panayiotopoulos C.P. (ed.). The Epilepsies: Seizures, Syndromes and Management. Oxford: Bladon, 2005. Pp. 223–69.

35. Panayiotopoulos C.P., Igoe D.M. Cerebral insult-like partial status epilepticus in the earlyonset variant of benign childhood epilepsy with occipital paroxysms. Seizure 1992;1: 99–102.

36. Pruna D., Persico I., Serra D. et al. Lack of association with the 15q14 candidate region for benign epilepsy of childhood with centrotemporal spikes in a Sardinian population. Epilepsia 2000;(Suppl Florence):164.

37. Shinnar S., O'Dell C., Berg A.T. Distribution of epilepsy syndromes in a cohort of children prospectively monitored from the time of their first unprovoked seizure. Epilepsia 1999;40(10):1378–83.

38. Sillanpaa M., Jalava M., Shinnar S. Epilepsy syndromes in patients with childhoodonset seizures in Finland. Pediatr Neurol 1999;21(2):533–7.

39. Tata G., Guveli B.T., Dortcan N. et al. Epileptic Disord 2014;16(2):197–202.

40. Verrotti A., Sebastiani M., Giordano L. et al. Panayiotopoulos syndrome with convulsive status epilepticus at the onset: a long-term study. Seizure 2014;23(9):728–31.

41. Vigevano F., Lispi M.L., Ricci S. Early onset benign occipital susceptibility syndrome: video-EEG documentation of an illustrative case. Clin Neurophysiol 2000;111(Suppl 2): S81–6.