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Русский журнал детской неврологии

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Применение зонисамида (Зонеграна) в лечении эпилепсии у взрослых и детей (обзор зарубежной литературы и описание случая)

https://doi.org/10.17650/2073-8803-2015-1-47-63

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Аннотация

Несмотря на значительные успехи, достигнутые в эпилептологии, резистентные эпилепсии составляют примерно 30 % среди всех форм эпилепсии. Представлен обзор современной литературы, посвященной эффективности и безопасности нового антиэпилептического препарата зонисамид (Зонегран) в лечении эпилепсии, с акцентом на монотерапию. Описаны механизм действия, особенности фармакокинетики, эффективность и переносимость зонисамида при резистентной фокальной эпилепсии, а также при других типах приступов и формах эпилепсии. Рассматриваются показания к применению препарата. Описаны также более широкие возможности применения зонисамида: в лечении генерализованных приступов, при монотерапии, а также у детей и подростков. В настоящее время Зонегран зарегистрирован для применения у детей (начиная с 6 лет и старше) с фокальными приступами в дополнительной терапии. Авторы представляют собственное наблюдение высокой эффективности зонисамида в дополнительной терапии у ребенка 9 лет с криптогенной фокальной эпилепсией. Дебют эпилептических приступов в возрасте 5 месяцев. С момента начала заболевания ребенок получал множество антиэпилептических препаратов в разных комбинациях, без существенного эффекта. Зонисамид (Зонегран) был введен в терапию 4 мес назад в комбинации с препаратом вальпроевой кислоты (который ребенок получал на протяжении многих лет), и с момента выхода на полную дозу эпилептические приступы до настоящего времени отсутствуют. Следует отметить, что ремиссии длительностью 4 мес не было ни разу с момента начала заболевания. Также отмечалась нормализация сна. Переносимость терапии хорошая. Побочных эффектов не отмечалось.

Об авторах

К. Ю. Мухин
ООО «Институт детской неврологии и эпилепсии им. Святителя Луки»; Россия, 143396, Москва, Троицк, п. Пучково, ул. Светлая, 6
Россия


О. А. Пылаева
ООО «Институт детской неврологии и эпилепсии им. Святителя Луки»; Россия, 143396, Москва, Троицк, п. Пучково, ул. Светлая, 6
Россия


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Для цитирования:


Мухин К.Ю., Пылаева О.А. Применение зонисамида (Зонеграна) в лечении эпилепсии у взрослых и детей (обзор зарубежной литературы и описание случая). Русский журнал детской неврологии. 2015;10(1):47-63. https://doi.org/10.17650/2073-8803-2015-1-47-63

For citation:


Мukhin K.Y., Pylaeva O.A. ZONISAMIDE (ZONEGRAN) IN THE TREATMENT OF EPILEPSY IN ADULTS AND CHILDREN (A REVIEW AND CLINICAL CASE). Russian Journal of Child Neurology. 2015;10(1):47-63. (In Russ.) https://doi.org/10.17650/2073-8803-2015-1-47-63

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