Continuous spike-and-wave activity during slow-wave sleep in patients with rett syndrome
https://doi.org/10.17650/2073-8803-2021-16-1-2-63-68
Abstract
The article presents a description of a clinical case of a child 3 years 8 months old with Rett syndrome caused by the mutation of p.Val485fs in the MECP2 gene. According to electroencephalography data at the age of 1 year and 6 months, diffuse continued epileptiform activity in the form of high-amplitude (up to 300 μV) acute – slow wave complexes (continuous spike-waves during slow-wave sleep, CSWS) with an index of 90–100 % was revealed. At the control examination at the age of 2 years and 10 months diffuse epileptiform activity was replaced by multifocal activity with an index of up to 70–80 % at certain epochs, in general, not exceeding 50–60 %. During the entire observation period there were no epileptic seizures. It remains unknown whether the presence of CSWS at such an early age is a predictor of a more severe course of Rett syndrome – in our observation the girl did not acquire walking skills and a delay in psychic and speech development was evident already before the 12 month of life. more research is needed on the frequency of the CSWS phenomenon and its role in the development of clinical features in Rett syndrome.
About the Authors
S. L. Kulikova
Republican Research and Practical Center of Neurology and Neurosurgery
Belarus
Belarus
Svetlana Leonidovna Kulikova
24 Frantsiska Skoriny St., Minsk 220114
I. V. Kozyreva
Republican Research and Practical Center of Neurology and Neurosurgery
Belarus
Belarus
24 Frantsiska Skoriny St., Minsk 220114
S. A. Likhachev
Republican Research and Practical Center of Neurology and Neurosurgery
Belarus
Belarus
24 Frantsiska Skoriny St., Minsk 220114
M. Yu. Bobylova
Svt. Luka’s Institute of Child Neurology and Epilepsy; Svt. Luka’s Institute of Child and Adult Neurology and Epilepsy
Russian Federation
Russian Federation
5 Nagornaya St., Troitsk, Moscow 108840
9 Akademika Anokhina St., Moscow 119579
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Review
For citations:
Kulikova S.L., Kozyreva I.V., Likhachev S.A., Bobylova M.Yu. Continuous spike-and-wave activity during slow-wave sleep in patients with rett syndrome. Russian Journal of Child Neurology. 2021;16(1-2):63-68. (In Russ.) https://doi.org/10.17650/2073-8803-2021-16-1-2-63-68
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