The effectiveness of therapy correction in children with paroxysmal disorders of consciousness based on the results of video electroencephalographic monitoring
https://doi.org/10.17650/2073-8803-2020-15-3-4-26-34
Abstract
Background. An important condition for adequate drug therapy is the early differential diagnosis of paroxysmal conditions in children, the estab lishment or clarification of their epileptic or non-epileptic nature.
Objective: to demonstrate the necessity, effectiveness and safety of the correction therapy in children with paroxysmal disorders of consciousness according to results of complex investigation, including video-electroencephalographic monitoring.
Materials and methods. A comprehensive examination with the inclusion of video-electroencephalographic monitoring was carried out in 527 pa tients referred by neurologists to clarify the nature of paroxysmal consciousness disorder, clarify the form of epilepsy, and select an adequate treatment.
Results. Based on the results obtained during the comprehensive examination of children with video-electroencephalographic monitoring, in all the examined children the diagnosed was corrected. According to the results of the survey, it was found that 210 children had non-epileptic paroxysms. In the overwhelming majority of cases, the treatment was changed.
Conclusions. The presented results of treatment of children with epileptic and non-epileptic paroxysms after correction of treatment indicate the need for careful analysis of all data (clinical and anamnestic, electroencephalographic, laboratory) for correct diagnosis, identification of causes of resistance and reasonable selection of therapy in each patient.
About the Authors
V. I. Guzeva
Saint Petersburg State Pediatric Medical University,
Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology, Neurosurgery and Medical Genetics
2 Litovskaya St., Saint Petersburg 194100
O. V. Guzeva
Saint Petersburg State Pediatric Medical University,
Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology, Neurosurgery and Medical Genetics
2 Litovskaya St., Saint Petersburg 194100
V. V. Guzeva
Saint Petersburg State Pediatric Medical University,
Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology, Neurosurgery and Medical Genetics
2 Litovskaya St., Saint Petersburg 194100
I. V. Okhrim
Saint Petersburg State Pediatric Medical University,
Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology, Neurosurgery and Medical Genetics
2 Litovskaya St., Saint Petersburg 194100
Yu. A. Eremkina
Saint Petersburg State Pediatric Medical University,
Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology, Neurosurgery and Medical Genetics
2 Litovskaya St., Saint Petersburg 194100
V. V. Orel
Saint Petersburg State Pediatric Medical University,
Ministry of Health of Russia
Russian Federation
Russian Federation
Department of Neurology, Neurosurgery and Medical Genetics
2 Litovskaya St., Saint Petersburg 194100
References
1. Aykardi Zh. Diseases of the nervous system in children. Vol. 1. Moscow: Izdatelstvo Panfilova, 2013. 556 p. (In Russ.).
2. Gubler E.V. Informatics in pathology, clinical medicine, and pediatrics. Moscow: Meditsina, 1990. 176 p. (In Russ.).
3. Guzeva V.I. Main etiopathogenetic factors and their role in clinical manifestations, prognosis, and treatment of epilepsy in children. Epilepsy. Ed. by N.G. Neznanov. Saint Petersburg, 2010. Pp. 263–322. (In Russ.).
4. Guzeva V.I. Video-EEG monitoring in the diagnosis of epileptic and non-epileptic paroxysmal conditions in children. Epilepsiya i paroksizmalnye sostoyaniya = Epilepsy and Paroxysmal Conditions 2010;2(3):12–9. (In Russ.).
5. Guzeva V.I. Pediatric neurology: guidelines. 3rd edn. Moscow: Medical Information Agency, 2009. 640 p. (In Russ.).
6. ГGuzeva V.I. Epilepsy and non-epileptic paroxysmal disorders in children. Moscow: Medical Information Agency, 2007. 568 p. (In Russ.).
7. Guzeva O.V. Role of comprehensive clinical and electrophysiological examination in differential diagnosis and treatment of paroxysmal disorders of consciousness in children. Yakutskiy meditsinskiy zhurnal = Yakut Medical Journal 2011;2(34):68–72. (In Russ.).
8. Guzeva O.V. Clinical and electroencephalographic criteria for the diagnosis of epileptic and non- epileptic paroxysmal disorders of consciousness in children. Neirokhirurgiya i nevrologiya detskogo vozrasta = Pediatric Neurosurgery and Neurology 2010;3–4(25–26):25–36. (In Russ.).
9. Guzeva O.V. Non-epileptic paroxysmal disorders of consciousness in children. Clinical and electrophysiological comparison. Vestnik SZGMU im. I.I. Mechnikova = Journal of I.I. Mechnikov North-Western State Medical University 2009;3(32):46–9. (In Russ.).
10. Karlov V.A. Epilepsy in children and adult women and men: guideline for physicians. Moscow: Meditsina, 2010. 717 p. (In Russ.).
11. Karlov V.A. Current strategy and tactics of epilepsy treatment. Zhurnal nevropatologii i psikhiatrii im. S.S. Korsakova = S.S. Korsakov Journal of Neuropathology and Psychiatry 2004;104(8):28–34. (In Russ.).
12. Mukhin K.Yu., Petrukhin A.S., Vasilyeva I.A. Current aspects of diagnosis and treatment of epilepsy in children and adolescent. Psikhiatriya i psikhofarmakoterapiya = Psychiatry and Psychopharmacotherapy 2004;6(1):14–20. (In Russ.).
13. Avanzini G. Tolerance during prolonged AED treatment. In: Epileptology in medicine of the XX century. Eds.: E.I. Gusev, A.B. Hecht. M., 2009. Pp. 403–406.
14. Brodie M.J. Antiepileptic drugs: past, present and future. Abstract Book 7th Asian & Oceanian Epilepsy Congress. China, 2008. P. 3.
15. Chadwick D. The treatment of the seizure: The benefits. Epilepsia 2008;49:26–8. DOI: 10.1111/j.1528-1167.2008.01446.x.
16. French J.A., Kanner A.M., Bautista J. et al. Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62(8):1261–73. DOI: 10.1212/01.wnl.0000123695.22623.32.
17. Neuwirth M., Paraicz E., Liptai Z. Devastating epileptic encephalopathy – pseudoencephalitis: the new type of catastrophe epilepsy in our department. Ideggyogy Sz 2008;61(11–12):391–6.
18. Neville B., Chin R., Scott R. Clinical trial design in status epilepticus: problems and solutions. 1st London Colloquium on Status Epilepticus. Platform presentation: Abstracts. London, 2007. Pp. 40–1.
19. Nordili D.R. Early identification of drug resistant patients. Drug resistant epilepsy. UK John Libbey Eurotext, 2008. Pp. 187–198.
20. Shorvon S. Handdbook of epilepsy treatment. 2nd edn. Blackwell Publishing, 2005. 304 p.
Review
For citations:
Guzeva V.I., Guzeva O.V., Guzeva V.V., Okhrim I.V., Eremkina Yu.A., Orel V.V. The effectiveness of therapy correction in children with paroxysmal disorders of consciousness based on the results of video electroencephalographic monitoring. Russian Journal of Child Neurology. 2020;15(3-4):26-34. (In Russ.) https://doi.org/10.17650/2073-8803-2020-15-3-4-26-34
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