Series of patients with febrile status epilepticus: clinical manifestations and long-term follow-up
https://doi.org/10.17650/2073-8803-2020-15-1-28-39
Abstract
Background. The conception of febrile status epilepticus includes many syndromes with seizures of different etiologies (fever, infection, autoimmune processes, etc.). Generally developing seizures have a severe course and are difficult to treat.
Objective: to classify patients with febrile status epilepticus and study their long-term prognosis.
Materials and methods. The study included 10 patients (children and adolescents), hospitalized in the intensive care unit, whose epileptic status were associated with a fever.
Results. In the analysis of the patients, who were included in the study, 4 subgroups can be distinguished: 1) a short-term period of convulsion against the background of metabolic decompensation caused by a main disease (with a conditionally favorable prognosis for seizures); 2) seizures as a manifestation of organic brain damage or infectious diseases with a serious prognosis of neurological development and seizures; 3) the onset of seizures against the background of fever (absence of any other causes of seizures); the prognosis of getting rid of seizures is variable, long follow-up monitoring is necessary, probably for many years; 4) true febrile infection-related epilepsy syndrome (in our study 1 patient had its classical form, and 1 patient had its less typical form (the onset of the disease at 18 years old – not at school age)).
Conclusions. Obtained data illustrate the whole severity of febrile status epilepticus in children, according to follow-up observation, seizures persisted in at least 3 out of 10 patients (2 of them with febrile infection-related epilepsy syndrome), at least three patients had a serious infectious or organic brain pathology.
About the Authors
V. E. Kitaeva
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Russian Federation
Russian Federation
20/1 Delegatskaya St., Moscow 127473, Russi
A. S. Kotov
M.F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
61/2 Shchepkina St., Moscow 129110, Russia
Russian Federation
61/2 Shchepkina St., Moscow 129110, Russia
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Review
For citations:
Kitaeva V.E., Kotov A.S. Series of patients with febrile status epilepticus: clinical manifestations and long-term follow-up. Russian Journal of Child Neurology. 2020;15(1):28-39. (In Russ.) https://doi.org/10.17650/2073-8803-2020-15-1-28-39
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