USE OF THE NEW ANTIEPILEPTIC DRUG PERAMPANEL (FYCOMPA) IN THE TREATMENT OF EPILEPSY: A REVIEW OF FOREIGN LITERATURE
https://doi.org/10.17650/2073-8803-2014-9-3-36-42
Abstract
Despite a considerable advance made in epileptology, resistant epilepsies are about 30% among all epilepsy types particularly in patients with focal seizures. In these cases, there is hope for the success of neurosurgical treatment and the synthesis of new antiepileptic drugs (AEDs). The authors provide a review of the literature dealing the new AED perampanel (Fycompa) and consider its mechanism of action, pharmacokinetics, clinical and postmarketing trials of its efficacy, tolerability, and safety. Based on the data available in the literature, it may be concluded that parampanel is a promising highly effective and well tolerated AED to treat partial and secondary generalized seizures.
About the Authors
O. A. Pylaeva
Svt. Luka’s Institute of Child Neurology and Epilepsy, Moscow
Russian Federation
Russian Federation
K. Yu. Mukhin
Svt. Luka’s Institute of Child Neurology and Epilepsy, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Pylaeva O.A., Mukhin K.Yu. USE OF THE NEW ANTIEPILEPTIC DRUG PERAMPANEL (FYCOMPA) IN THE TREATMENT OF EPILEPSY: A REVIEW OF FOREIGN LITERATURE. Russian Journal of Child Neurology. 2014;9(3):36-42. (In Russ.) https://doi.org/10.17650/2073-8803-2014-9-3-36-42
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