Дискуссионные вопросы коморбидности аутизма и эпилепсии: субклиническая эпилептиформная активность и аутистический эпилептиформный регресс

Ранний детский аутизм, или расстройства аутистического спектра, – крайне разнородная группа состояний, объединенных едиными признаками дизонтогенеза. Наиболее значимым коморбидным заболеванием при аутизме является эпилепсия, с которой связано большое количество дискуссионных до настоящего времени вопросов.

Авторы представляют обзор данных литературы по следующим наиболее дискуссионным и спорным вопросам коморбидности аутизма и эпилепсии: влияние проводимой психофармакотерапии на риск развития эпилепсии; клиническое значение эпилептиформной активности на электроэнцефалограмме при отсутствии эпилепсии; критерии и встречаемость синдрома аутистического эпилептиформного регресса. Выявлено, что по большинству анализируемых вопросов о сочетании аутизма и эпилепсии до настоящего времени недостаточно достоверных и доказательных данных. Подчеркивается значимость дальнейших исследований. Дан подробный анализ истории возникновения, критериев, встречаемости, клинических примеров и дискуссионности синдрома аутистического эпилептиформного регресса.

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