MUTATIONS IN THE ARX GENE: CLINICAL, ELECTROENCEPHALOGRAPHIC AND NEUROIMAGING FEATURES IN 3 PATIENTS
https://doi.org/10.17650/2073-8803-2017-12-3-58-67
Abstract
The Aristaless-related homeobox (ARX) gene is a member of the paired-type homeodomain transcription factor family with critical roles in embryonic development, particularly in the developing brain. Mutations in ARX gene demonstrate striking intra- and interfamilial pleiotropy together with genetic heterogeneity and lead to a broad spectrum of diseases. They give rise to 4 key phenotypic features: a different types of brain malformation, abnormal genitalia, epilepsy and intellectual disability. Authors present 3 clinical cases: a girl with duplication on the short arm of X-chromosome (Xp11.22-p22.33), which include genes ARX and CDKL5; a girl and a boy with a missense mutation in ARX gene that have not been previously described (chrX:25031522C>A), causes the substitution of an amino acid in the 197 protein position (p.Gly197Val, NM_139058.2). All patients suffer from severe epilepsy, that is refractory to antiepileptic drugs, and all of them have different degrees of psychomotor delay. The patients with missense mutation also have movement disorders: stereotypic movements in the girl and choreo athetosis and dystonia in the boy. Electroencephalographic abnormalities have been identified in all patients, and there were not significant abnormalities on magnetic resonance imaging in all cases. The described cases broaden the clinical spectrum of mutations in ARX gene.
About the Authors
I. V. Ivanova
Svt. Luka’s Institute of Child Neurology and Epilepsy
Russian Federation
5 Nagornaya St., Troitsk, Moscow 108840
Russian Federation
5 Nagornaya St., Troitsk, Moscow 108840
K. Yu. Mukhin
Svt. Luka’s Institute of Child Neurology and Epilepsy
Russian Federation
5 Nagornaya St., Troitsk, Moscow 108840
Russian Federation
5 Nagornaya St., Troitsk, Moscow 108840
O. A. Pylaeva
Svt. Luka’s Institute of Child Neurology and Epilepsy
Russian Federation
5 Nagornaya St., Troitsk, Moscow 108840
Russian Federation
5 Nagornaya St., Troitsk, Moscow 108840
M. Yu. Bobylova
Svt. Luka’s Institute of Child and Adult Neurology and Epilepsy
Russian Federation
9 Akademika Anokhina St., Moscow 119579
Russian Federation
9 Akademika Anokhina St., Moscow 119579
N. E. Kvaskova
Svt. Luka’s Institute of Child Neurology and Epilepsy
Russian Federation
5 Nagornaya St., Troitsk, Moscow 108840
Russian Federation
5 Nagornaya St., Troitsk, Moscow 108840
A. S. Petrukhin
Svt. Luka’s Institute of Child and Adult Neurology and Epilepsy
Russian Federation
9 Akademika Anokhina St., Moscow 119579
Russian Federation
9 Akademika Anokhina St., Moscow 119579
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Review
For citations:
Ivanova I.V., Mukhin K.Yu., Pylaeva O.A., Bobylova M.Yu., Kvaskova N.E., Petrukhin A.S. MUTATIONS IN THE ARX GENE: CLINICAL, ELECTROENCEPHALOGRAPHIC AND NEUROIMAGING FEATURES IN 3 PATIENTS. Russian Journal of Child Neurology. 2017;12(3):58-67. (In Russ.) https://doi.org/10.17650/2073-8803-2017-12-3-58-67
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