THE IMPACT OF H YPOTHALAMIC-PITUITARY-ADRENAL SYSTEM HORMONES ON EPILEPTOGENESIS

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Abstract

Some issues concerning the impact of hypothalamic-pituitary-adrenal system (HPAS) hormones on epileptogenesis are discussed in the article. It was found, that they have a direct and indirect impact. Direct effect implies the reduction of excitation level in the brain cells by affecting membrane channels and receptors involved in the regulation of certain neurotransmitters synthesis. Indirect effect is realized through positive influence on the brain neurons maturation process, leveling the stimulation of excitation processes mediated by biologically active substances, ions and other agents. Adrenocorticotropic hormone and glucocorticosteroids are the main hormones used in antiepileptic therapy. They have an impact both on epileptogenesis itself, and on induction/inhibition of their own effects in accordance with a feedback mechanism of hormones secretion. The mechanism of antiepileptic action of HPAS hormones allows considering them as true antiepileptic drugs for treatment of drug-resistant and special forms of epilepsy.

About the authors

L. V. Shalkevich

Belarusian Medical Academy of Postgraduate Education

Author for correspondence.
Email: shalkevich_@tut.by
3/3 P. Brovka St., Minsk 220013, Republic of Belarus Belarus

A. I. Kudlach

Belarusian Medical Academy of Postgraduate Education

Email: fake@neicon.ru
3/3 P. Brovka St., Minsk 220013, Republic of Belarus Belarus

O. P. Nazarova

Republican Research and Clinical center of Neurology and Neurosurgery

Email: fake@neicon.ru
24 F. Skorina St., Minsk 220114, Republic of Belarus Belarus

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