Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press7810.17650/2073-8803-2012-7-2-13-34REVIEWS AND LECTURESОБЗОРЫ И ЛЕКЦИИA NEW ANTIEPILEPTIC DRUG — ZONEGRAN (ZONISAMIDE) — IN THE TREATMENT OF EPILEPSY (A REVIEW)ПРИМЕНЕНИЕ НОВОГО АНТИЭПИЛЕПТИЧЕСКОГО ПРЕПАРАТА — ЗОНЕГРАН (ЗОНИСАМИД) — В ЛЕЧЕНИИ ЭПИЛЕПСИИ (ОБЗОР ЛИТЕРАТУРЫ)PylaevaO. A.ПылаеваО. А.
Russian Federation
МukhinK. Yu.МухинК. Ю.
Russian Federation
Институт детской неврологии и эпилепсии имени Святителя Луки, Москва150420127213341707201517072015Copyright ©; 2012, ABV-PressCopyright ©; 2012, АБВ-пресс2012ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/78

Despite the considerable advances of epileptology drug-resistant epilepsies consist about 30% among all forms of epilepsy. Authors represent the review of the literature devoted to efficacy and tolerability of zonisamide in the treatment of drug-resistant epilepsy. The current review of studies devoted to efficacy and safety of a new antiepileptic drug zonisamide in the treatment of epilepsy is proposed. The mechanism of action and pharmacokinetic of zonisamide are described; the questions of efficacy and tolerability in the treatment of drug-resistant focal epilepsies and other types of seizures and forms of epilepsy are considered. The possibilities of the use of the drug in the treatment of comorbid disorders are considered

Несмотря на значительные успехи, достигнутые в эпилептологии, резистентные эпилепсии составляют примерно 30% среди всех форм эпилепсии. Представлен обзор современной литературы, посвященный эффективности и безопасности нового антиэпилептического препарата зонегран (зонисамид) в лечении эпилепсии. Рассмотрен механизм действия, особенности фармакокинетики, эффективность и переносимость зонисамида при резистентной фокальной эпилепсии, а также при других типах приступов и формах эпилепсии. Рассматриваются возможности применения зонисамида при коморбидных состояниях.

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