<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Child Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Child Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Русский журнал детской неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-8803</issn><issn publication-format="electronic">2412-9178</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">77</article-id><article-id pub-id-type="doi">10.17650/2073-8803-2012-7-2-3-12</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">EFFICACY OF VIMPAT (LACOSAMIDE) TN THE TREATMENT OF DRUG-RESISTANT CRYPTOGENIC FOCAL EPILEPSY WITH FOCAL AUTOMOTOR AND SECONDARILY GENERALIZED SEIZURES (A CLINICAL CASE)</article-title><trans-title-group xml:lang="ru"><trans-title>ЭФФЕКТИВНОСТЬ ВИМПАТА (ЛАКОСАМИД) У ПАЦИЕНТКИ С РЕЗИСТЕНТНОЙ ФОРМОЙ КРИПТОГЕННОЙ ФОКАЛЬНОЙ ЭПИЛЕПСИИ С ФОКАЛЬНЫМИ АУТОМОТОРНЫМИ И ВТОРИЧНО- ГЕНЕРАЛИЗОВАННЫМИ СУДОРОЖНЫМИ ПРИСТУПАМИ (ОПИСАНИЕ СЛУЧАЯ)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mironov</surname><given-names>M. B.</given-names></name><name xml:lang="ru"><surname>Миронов</surname><given-names>М. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mukhin</surname><given-names>K. Yu.</given-names></name><name xml:lang="ru"><surname>Мухин</surname><given-names>К. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pylaeva</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Пылаева</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Институт детской неврологии и эпилепсии имени Святителя Луки, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2012</year></pub-date><volume>7</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>3</fpage><lpage>12</lpage><history><date date-type="received" iso-8601-date="2015-07-17"><day>17</day><month>07</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-07-17"><day>17</day><month>07</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, АБВ-пресс</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://rjdn.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://rjdn.abvpress.ru/jour/article/view/77">https://rjdn.abvpress.ru/jour/article/view/77</self-uri><abstract xml:lang="en"><p>Despite the considerable advances of epileptology drug-resistant epilepsies consist about 30% among all forms of epilepsy. A case of successful using of a new antiepileptic drug lacosamide (vimpat) in the treatment of 31 years old patient with the resistant form of cryptogenic focal epilepsy with focal automotor and secondarily generalized seizures is presented. Authors represent the review of the literature devoted to efficacy and tolerability of lacosamide in the treatment of drug-resistant epilepsy.</p></abstract><trans-abstract xml:lang="ru"><p>Несмотря на значительные успехи, достигнутые в эпилептологии, резистентные эпилепсии составляют примерно 30% среди всех форм эпилепсии. Представлено описание случая применения нового антиэпилептического препарата лакосамид (вимпат) и достижения ремиссии приступов у пациентки 31 года с резистентной формой криптогенной фокальной эпилепсии с фокальными аутомоторными и вторично-генерализованными судорожными приступами. Представлен обзор литературы, посвященной эффективности и переносимости лакосамида при резистентной эпилепсии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>epilepsy</kwd><kwd>drug-resistant epilepsy</kwd><kwd>lacosamide</kwd><kwd>efficacy</kwd><kwd>tolerability.</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>эпилепсия</kwd><kwd>резистентная к терапии эпилепсия</kwd><kwd>лакосамид</kwd><kwd>эффективность</kwd><kwd>переносимость.</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Зенков Л.Р. Противоэпилептический препарат лакосамид (вимпат) // Журн неврол психиатр. — 2010. — Т. 110. — №10. — С. 72–79.</mixed-citation><mixed-citation xml:lang="ru">Зенков Л.Р. Противоэпилептический препарат лакосамид (вимпат) // Журн неврол психиатр. — 2010. — Т. 110. — №10. — С. 72–79.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Воронкова К.В., Пылаева О.А., Федин А.И. Современные принципы лечения фокальных эпилепсий // Эпилепсия. — 2011. — №1 (4). — С. 2–14.</mixed-citation><mixed-citation xml:lang="ru">Воронкова К.В., Пылаева О.А., Федин А.И. Современные принципы лечения фокальных эпилепсий // Эпилепсия. — 2011. — №1 (4). — С. 2–14.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Мильчакова Л.Е., Гехт А.Б. Эффективность и безопасность нового противоэпилептического препарата лакосамид у больных фокальной эпилепсией (данные двойных слепых плацебо-контролируемых исследований) // Журн неврол психиатр. — 2010. — Т. 110, N 3. — вып. 2. — С. 39–43.</mixed-citation><mixed-citation xml:lang="ru">Мильчакова Л.Е., Гехт А.Б. Эффективность и безопасность нового противоэпилептического препарата лакосамид у больных фокальной эпилепсией (данные двойных слепых плацебо-контролируемых исследований) // Журн неврол психиатр. — 2010. — Т. 110, N 3. — вып. 2. — С. 39–43.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Мухин К.Ю., Петрухин А.С., Миронов М.Б. Эпилептические синдромы. Диагностика и терапия (справочное руководство) // М.: Системные решения, 2008. — 224 с.</mixed-citation><mixed-citation xml:lang="ru">Мухин К.Ю., Петрухин А.С., Миронов М.Б. Эпилептические синдромы. Диагностика и терапия (справочное руководство) // М.: Системные решения, 2008. — 224 с.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Мухин К.Ю., Тысячина М.Д., Глухова Л.Ю., Фрейдкова Н.В. Клинический случай применения лакосамида (вимпат) в лечении резистентной формы симптоматической фокальной эпилепсии // Рус. жур. дет. невр. — 2011. — Т. VI. — Вып. 2. — С. 37–42.</mixed-citation><mixed-citation xml:lang="ru">Мухин К.Ю., Тысячина М.Д., Глухова Л.Ю., Фрейдкова Н.В. Клинический случай применения лакосамида (вимпат) в лечении резистентной формы симптоматической фокальной эпилепсии // Рус. жур. дет. невр. — 2011. — Т. VI. — Вып. 2. — С. 37–42.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Benhaddi H., Gunn A., Ferro B. Medico-economic evaluation of lacosamide adjunctive therapy in the treatment of patients with refractory epilepsy in Scotland and Spain //13 th Annual European Congress: health technology assessment 6-9 November 2010, Prague.</mixed-citation><mixed-citation xml:lang="ru">Benhaddi H., Gunn A., Ferro B. Medico-economic evaluation of lacosamide adjunctive therapy in the treatment of patients with refractory epilepsy in Scotland and Spain //13 th Annual European Congress: health technology assessment 6-9 November 2010, Prague.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Ben-Menachem E., Biton V., Jatuzis D., Abou-Khalil B., Doty P., Rudd G.D. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures // Epilepsia. — 2007. — V. 48(7). — P. 1308–17.</mixed-citation><mixed-citation xml:lang="ru">Ben-Menachem E., Biton V., Jatuzis D., Abou-Khalil B., Doty P., Rudd G.D. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures // Epilepsia. — 2007. — V. 48(7). — P. 1308–17.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Ben-Menachem E. Lacosamide: an investigational drug for adjunctive treatment of partial-onset seizures // Drugs Today (Barc). — 2008. — V. 44(1). — P. 35–40.</mixed-citation><mixed-citation xml:lang="ru">Ben-Menachem E. Lacosamide: an investigational drug for adjunctive treatment of partial-onset seizures // Drugs Today (Barc). — 2008. — V. 44(1). — P. 35–40.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Biton V., Rosenfeld W.E., Whitesides J., Fountain N.B., Vaiciene N., Rudd G.D. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures // Epilepsia. — 2008. — V. 49(3). — P. 418–24.</mixed-citation><mixed-citation xml:lang="ru">Biton V., Rosenfeld W.E., Whitesides J., Fountain N.B., Vaiciene N., Rudd G.D. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures // Epilepsia. — 2008. — V. 49(3). — P. 418–24.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Bolin K., Berggren F., Forsgren L. Lacosamide as treatment of epileptic seizures — cost utility results for Sweden // Acta Neurol Scand. — 2010. — V. 121(6). — P. 406–12.</mixed-citation><mixed-citation xml:lang="ru">Bolin K., Berggren F., Forsgren L. Lacosamide as treatment of epileptic seizures — cost utility results for Sweden // Acta Neurol Scand. — 2010. — V. 121(6). — P. 406–12.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Chung S., Sperling M.R., Biton V., Krauss G., Hebert D., Rudd G.D., Doty P.; SP754 Study Group. Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial // Epilepsia. — 2010. — V. 51(6). — P. 958–67.</mixed-citation><mixed-citation xml:lang="ru">Chung S., Sperling M.R., Biton V., Krauss G., Hebert D., Rudd G.D., Doty P.; SP754 Study Group. Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial // Epilepsia. — 2010. — V. 51(6). — P. 958–67.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12.Chung S., Ben-Menachem E., Sperling M.R., Rosenfeld W., Fountain N.B., Benbadis S., Hebert D., Isojarvi J., Doty P. Examining the clinical utility of lacosamide: pooled analyses of three phase II/III clinical trials // CNS Drugs. — 2010. — V. 24(12). — P. 1041–54.</mixed-citation><mixed-citation xml:lang="ru">Chung S., Ben-Menachem E., Sperling M.R., Rosenfeld W., Fountain N.B., Benbadis S., Hebert D., Isojarvi J., Doty P. Examining the clinical utility of lacosamide: pooled analyses of three phase II/III clinical trials // CNS Drugs. — 2010. — V. 24(12). — P. 1041–54.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Elger C.E., Schmidt D. Modern management of epilepsy: A practical approach // Epilepsy &amp; Behavior. — 2008. — V. 12. — P. 501–539.</mixed-citation><mixed-citation xml:lang="ru">Elger C.E., Schmidt D. Modern management of epilepsy: A practical approach // Epilepsy &amp; Behavior. — 2008. — V. 12. — P. 501–539.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Errington A.C., Coyne L., Stohr T., Selve N., Lees G. Seeking a mechanism of action for the novel anticonvulsant lacosamide // Neuropharmacology. — 2006. — V. 50(8). — P. 1016–29.</mixed-citation><mixed-citation xml:lang="ru">Errington A.C., Coyne L., Stohr T., Selve N., Lees G. Seeking a mechanism of action for the novel anticonvulsant lacosamide // Neuropharmacology. — 2006. — V. 50(8). — P. 1016–29.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Errington A.C., Stohr T., Heers C., Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels // Mol Pharmacol. — 2008. — V. 73(1). — P. 157–69.</mixed-citation><mixed-citation xml:lang="ru">Errington A.C., Stohr T., Heers C., Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels // Mol Pharmacol. — 2008. — V. 73(1). — P. 157–69.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Freitag J.M., Beyreuther B., Heers C., Stoehr T. Lacosamide modulates collapsin response mediator protein 2 (CRMP-2) // Epilepsia. — 2007. — V. 48. — P. 320.</mixed-citation><mixed-citation xml:lang="ru">Freitag J.M., Beyreuther B., Heers C., Stoehr T. Lacosamide modulates collapsin response mediator protein 2 (CRMP-2) // Epilepsia. — 2007. — V. 48. — P. 320.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Gavatha M., Ioannou I., Papavasiliou A.S. Efficacy and tolerability of oral lacosamide as adjunctive therapy in pediatric patients with pharmacoresistant focal epilepsy // Epilepsy Behav. — 2011. — V. 20(4). — P. 691–3.</mixed-citation><mixed-citation xml:lang="ru">Gavatha M., Ioannou I., Papavasiliou A.S. Efficacy and tolerability of oral lacosamide as adjunctive therapy in pediatric patients with pharmacoresistant focal epilepsy // Epilepsy Behav. — 2011. — V. 20(4). — P. 691–3.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Garcia-Morales I., Delgado R.T., Falip M., Campos D., Garcia M.E., Gil-Nagel A. Early clinical experience with lacosamide as adjunctive therapy in patients with refractory focal epilepsy and nocturnal seizures // Seizure. — 2011. — V. 20(10). — P. 801–4.</mixed-citation><mixed-citation xml:lang="ru">Garcia-Morales I., Delgado R.T., Falip M., Campos D., Garcia M.E., Gil-Nagel A. Early clinical experience with lacosamide as adjunctive therapy in patients with refractory focal epilepsy and nocturnal seizures // Seizure. — 2011. — V. 20(10). — P. 801–4.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Gil-Nagel A., Marin H. Lacosamide: a new generation in the treatment of epilepsy // Rev Neurol. — 2011. —V. 52 (3). — P. 159–62.</mixed-citation><mixed-citation xml:lang="ru">Gil-Nagel A., Marin H. Lacosamide: a new generation in the treatment of epilepsy // Rev Neurol. — 2011. —V. 52 (3). — P. 159–62.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Glauser T., Ben-Menachem E., Bourgeois B., Cnaan A., Chadwick D., Guerreiro C., et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes // Epilepsia. — 2006. — V. 47. — P. 1094–120.</mixed-citation><mixed-citation xml:lang="ru">Glauser T., Ben-Menachem E., Bourgeois B., Cnaan A., Chadwick D., Guerreiro C., et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes // Epilepsia. — 2006. — V. 47. — P. 1094–120.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Guilhoto L.M., Loddenkemper T., Gooty V.D., Rotenberg A., Takeoka M., Duffy F.H., Coulter D., Urion D., Bourgeois B.F., Kothare S.V. Experience with lacosamide in a series of children with drug-resistant focal epilepsy // Pediatr Neurol. — 2011. — V. 44(6). — P. 414–9.</mixed-citation><mixed-citation xml:lang="ru">Guilhoto L.M., Loddenkemper T., Gooty V.D., Rotenberg A., Takeoka M., Duffy F.H., Coulter D., Urion D., Bourgeois B.F., Kothare S.V. Experience with lacosamide in a series of children with drug-resistant focal epilepsy // Pediatr Neurol. — 2011. — V. 44(6). — P. 414–9.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Halasz P., Kalviainen R., Mazurkiewicz-Beldzinska M., Rosenow F., Doty P., Hebert D., Sullivan T; SP755 Study Group. Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial // Epilepsia. — 2009. — V. 50(3). — P. 443–53.</mixed-citation><mixed-citation xml:lang="ru">Halasz P., Kalviainen R., Mazurkiewicz-Beldzinska M., Rosenow F., Doty P., Hebert D., Sullivan T; SP755 Study Group. Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial // Epilepsia. — 2009. — V. 50(3). — P. 443–53.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Hao X.T., Wong I.S., Kwan P. Interrater reliability of the international consensus definition of drug-resistant epilepsy: a pilot study // Epilepsy Behav. — 2011. — V. 22(2). — P. 388–90.</mixed-citation><mixed-citation xml:lang="ru">Hao X.T., Wong I.S., Kwan P. Interrater reliability of the international consensus definition of drug-resistant epilepsy: a pilot study // Epilepsy Behav. — 2011. — V. 22(2). — P. 388–90.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Harden C.L., Cohn A., Lowe M., Serrano E. Initial post marketing experience with lacosamide in adult patients with epilepsy // Epilepsy Res. — 2011 Oct 18. [Epub ahead of print]</mixed-citation><mixed-citation xml:lang="ru">Harden C.L., Cohn A., Lowe M., Serrano E. Initial post marketing experience with lacosamide in adult patients with epilepsy // Epilepsy Res. — 2011 Oct 18. [Epub ahead of print]</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Harris J.A., Murphy J.A. Lacosamide and Epilepsy // CNS Neurosci Ther. — 2010 Oct 15. doi: 10.1111/j.1755-5949.2010.00198.x.</mixed-citation><mixed-citation xml:lang="ru">Harris J.A., Murphy J.A. Lacosamide and Epilepsy // CNS Neurosci Ther. — 2010 Oct 15. doi: 10.1111/j.1755-5949.2010.00198.x.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Harris J.A., Murphy J.A. Lacosamide: an adjunctive agent for partial-onset seizures and potential therapy for neuropathic pain // Ann Pharmacother. — 2009. — V. 43(11). — P. 1809–17.</mixed-citation><mixed-citation xml:lang="ru">Harris J.A., Murphy J.A. Lacosamide: an adjunctive agent for partial-onset seizures and potential therapy for neuropathic pain // Ann Pharmacother. — 2009. — V. 43(11). — P. 1809–17.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Johannessen S.I., Ben-Menachem E. Management of Focal-Onset Seizures. An Update on Drug Treatment // Drugs. — 2006. — V. 66 (13). — P. 1701–1725.</mixed-citation><mixed-citation xml:lang="ru">Johannessen S.I., Ben-Menachem E. Management of Focal-Onset Seizures. An Update on Drug Treatment // Drugs. — 2006. — V. 66 (13). — P. 1701–1725.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Kelemen A., Halasz P. Lacosamide for the prevention of partial onset seizures in epileptic adults // Neuropsychiatr Dis Treat. — 2010. — V. 6. — P. 465–71.</mixed-citation><mixed-citation xml:lang="ru">Kelemen A., Halasz P. Lacosamide for the prevention of partial onset seizures in epileptic adults // Neuropsychiatr Dis Treat. — 2010. — V. 6. — P. 465–71.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Kellinghaus C. Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety // Ther Clin Risk Manag. — 2009. — V. 5. — P. 757–66.</mixed-citation><mixed-citation xml:lang="ru">Kellinghaus C. Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety // Ther Clin Risk Manag. — 2009. — V. 5. — P. 757–66.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Krauss G., Ben-Menachem E., Mameniskiene R., Vaiciene-Magistris N., Brock M., Whitesides J.G., Johnson M.E.; SP757 Study Group. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures // Epilepsia. — 2010. — V. 51(6). — P. 951–7.</mixed-citation><mixed-citation xml:lang="ru">Krauss G., Ben-Menachem E., Mameniskiene R., Vaiciene-Magistris N., Brock M., Whitesides J.G., Johnson M.E.; SP757 Study Group. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures // Epilepsia. — 2010. — V. 51(6). — P. 951–7.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Kwan P., Brodie M.J. Refractory epilepsy: mechanisms and solutions // Expert Rev Neurother. — 2006. — V. 6(3). — P. 397–406.</mixed-citation><mixed-citation xml:lang="ru">Kwan P., Brodie M.J. Refractory epilepsy: mechanisms and solutions // Expert Rev Neurother. — 2006. — V. 6(3). — P. 397–406.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Kwan P., Brodie M.J. Epilepsy after the first drug fails: substitution or add-on? // Seizure. — 2000. — V. 9 (7). —P. 464–8.</mixed-citation><mixed-citation xml:lang="ru">Kwan P., Brodie M.J. Epilepsy after the first drug fails: substitution or add-on? // Seizure. — 2000. — V. 9 (7). —P. 464–8.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">33. Kwan P., Brodie M.J. Early identification of refractory epilepsy // N Engl J Med. — 2000. — V. 342(5). — P. 314–9.</mixed-citation><mixed-citation xml:lang="ru">Kwan P., Brodie M.J. Early identification of refractory epilepsy // N Engl J Med. — 2000. — V. 342(5). — P. 314–9.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">34. O'Brien T.J., Mosewich R.K., Britton J.W., Cascino G.D., So E.L. History and seizure semiology in distinguishing frontal lobe seizures and temporal lobe seizures // Epilepsy Res. — 2008. — V. 82(2–3). — P. 177–82.</mixed-citation><mixed-citation xml:lang="ru">O'Brien T.J., Mosewich R.K., Britton J.W., Cascino G.D., So E.L. History and seizure semiology in distinguishing frontal lobe seizures and temporal lobe seizures // Epilepsy Res. — 2008. — V. 82(2–3). — P. 177–82.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">35. Panayotopoulos С.P. Principles of Therapy in the Epilepsies / In: Panayotopoulos. A Clinical Guide to Epileptic Syndromes and their Treatment. — Springer, 2007. — P. 155–184.</mixed-citation><mixed-citation xml:lang="ru">Panayotopoulos С.P. Principles of Therapy in the Epilepsies / In: Panayotopoulos. A Clinical Guide to Epileptic Syndromes and their Treatment. — Springer, 2007. — P. 155–184.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">36. Rosenow F., Knake S. Recent and future advances in the treatment of status epilepticus // Ther Adv Neurol Disord. — 2008. — V. 1(1). — P. 33–42.</mixed-citation><mixed-citation xml:lang="ru">Rosenow F., Knake S. Recent and future advances in the treatment of status epilepticus // Ther Adv Neurol Disord. — 2008. — V. 1(1). — P. 33–42.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">37. Simoens S. Lacosamide as adjunctive therapy for partial-onset epileptic seizures: a review of the clinical and economic literature // Curr Med Res Opin. — 2011 May 12.</mixed-citation><mixed-citation xml:lang="ru">Simoens S. Lacosamide as adjunctive therapy for partial-onset epileptic seizures: a review of the clinical and economic literature // Curr Med Res Opin. — 2011 May 12.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">38. Simoens S. Budget impact analysis of adjunctive therapy with lacosamide for partial-onset epileptic seizures in Belgium // J Med Econ. — 2011. — V. 14(3). — P. 299–304.</mixed-citation><mixed-citation xml:lang="ru">Simoens S. Budget impact analysis of adjunctive therapy with lacosamide for partial-onset epileptic seizures in Belgium // J Med Econ. — 2011. — V. 14(3). — P. 299–304.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
