Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press7310.17650/2073-8803-2013-8-2-23-40REVIEWS AND LECTURESОБЗОРЫ И ЛЕКЦИИEPILEPSY AND RISK OF SUICIDE (A REVIEW)ЭПИЛЕПСИЯ И РИСК СУИЦИДА (ОБЗОР ЛИТЕРАТУРЫ)PylaevaO. A.ПылаеваО. А.
Russian Federation
MukhinK. Yu.МухинК. Ю.
Russian Federation
ShatenshteynA. A.ШатенштейнА. А.
Russian Federation
Институт детской неврологии и эпилепсии им. Святителя Луки (ИДНЭ)Первый московский государственный медицинский университет им. И. М. Сеченова150420138223402506201525062015Copyright ©; 2013, ABV-PressCopyright ©; 2013, АБВ-пресс2013ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/73

The authors propose a fundamental review, devoted to the factors, wich increase the risk of suicidal behavior (suicidal ideation and suicide attempts) in patients with epilepsy. It is known, that suicidal risk is increased 5 times more in patients with epilepsy, and 25 times more in patients with temporal lobe epilepsy and complex focal seizures, than in general population. The main factors, increasing suicidal risk in epilepsy, are comorbid affective disorders (depression), and psychosis. The authors also describe the role of antiepileptic drugs.

Авторы представляют фундаментальный обзор, посвященный факторам, повышающим риск суицидального поведения (суицидальные мысли и действия) при эпилепсии. Известно, что риск суицида в 5 раз выше у пациентов с эпилепсией, и в 25 раз выше при височной эпилепсии и сложных парциальных приступах, чем среди населения в целом. Основными факторами, повышающими риск суицидального поведения при эпилепсии, считают сопутствующие аффективные нарушения (депрессия), а также психоз. Рассматривается также роль антиэпилептических препаратов.

epilepsyaffective disordersdepressionpsychosissuicidesuicidal ideationantiepileptic drugsэпилепсияаффективные нарушениядепрессияпсихозсуицидсуицидальные мыслиантиэпилептические препараты1. Бурд С.Г., Ридер Ф.К., Бадалян О.Л., Авакян Г.Г., Чуканова А.С. Депрессия и эпилепсия: две стороны одной медали // Рус. мед. журн. (Неврология). - 2008. - Т. 16. - № 12. - C. 1-5.Бурд С.Г., Ридер Ф.К., Бадалян О.Л., Авакян Г.Г., Чуканова А.С. Депрессия и эпилепсия: две стороны одной медали // Рус. мед. журн. (Неврология). - 2008. - Т. 16. - № 12. - C. 1-5.2. Воронкова К.В., Петрухин А.С., Пылаева О.А., Холин А.А. Рациональная антиэпилептическая фармакотерапия. - М: Бином, 2007 - 275 с.Воронкова К.В., Петрухин А.С., Пылаева О.А., Холин А.А. Рациональная антиэпилептическая фармакотерапия. - М: Бином, 2007 - 275 с.3. Калинин В.В. Эпилепсия как нейропсихиатрическая проблема // Психиатрия и фармакотерапия. - 2004. - Т. 06 (1).Калинин В.В. Эпилепсия как нейропсихиатрическая проблема // Психиатрия и фармакотерапия. - 2004. - Т. 06 (1).4. Калинин В.В., Полянский Д.А. Факторы риска развития суицидального поведения у больных эпилепсией // Журн неврол психиатр - 2003. - Т. 103, №3. - С. 18-21.Калинин В.В., Полянский Д.А. Факторы риска развития суицидального поведения у больных эпилепсией // Журн неврол психиатр - 2003. - Т. 103, №3. - С. 18-21.5. Киссин М.Я., Олина М.В., Пашкова И.М. Суицидальное поведение больных эпилепсией. Проблема антисуицидальных мотивов // Обозрение психиатрии и медицинской психологии им. Бехтерева. - 2011. - №1.Киссин М.Я., Олина М.В., Пашкова И.М. Суицидальное поведение больных эпилепсией. Проблема антисуицидальных мотивов // Обозрение психиатрии и медицинской психологии им. Бехтерева. - 2011. - №1.6. Пылаева О.А. Проблемы безопасности антиэпилептической терапии: влияние барбитуратов на психическое состояние, поведение и социальную адаптацию // Вестник эпилептологии - 2003. - № 1. - С. 8-11.Пылаева О.А. Проблемы безопасности антиэпилептической терапии: влияние барбитуратов на психическое состояние, поведение и социальную адаптацию // Вестник эпилептологии - 2003. - № 1. - С. 8-11.7. Пылаева О.А., Воронкова К.В., Петрухин А.С. Возникновение феномена «насильственной нормализации» в рамках психотических изменений у больных с эпилепсией // Журн неврол психиатр. - 2004. - № 7. - С. 72-74.Пылаева О.А., Воронкова К.В., Петрухин А.С. Возникновение феномена «насильственной нормализации» в рамках психотических изменений у больных с эпилепсией // Журн неврол психиатр. - 2004. - № 7. - С. 72-74.8. Пылаева О.А., Воронкова К.В., Петрухин А.С. Побочные эффекты и осложнения антиэпилептической терапии // Фарматека. - 2004. - № 9/10.Пылаева О.А., Воронкова К.В., Петрухин А.С. Побочные эффекты и осложнения антиэпилептической терапии // Фарматека. - 2004. - № 9/10.9. Пылаева О.А., Воронкова К.В., Петрухин А.С. Эффективность и безопасность антиэпилептической терапии у детей (сравнительная оценка препаратов вальпроевой кислоты и барбитуратов) // Журн неврол психиатр. - 2004. - Т. 104. - №8 - С. 61-65.Пылаева О.А., Воронкова К.В., Петрухин А.С. Эффективность и безопасность антиэпилептической терапии у детей (сравнительная оценка препаратов вальпроевой кислоты и барбитуратов) // Журн неврол психиатр. - 2004. - Т. 104. - №8 - С. 61-65.10. Пылаева О.А., Воронкова К.В., Холин А.А. Риск суицидального поведения при эпилепсии. Роль антиэпилептической терапии (обзор литературы) // Вестник эпилептологии. - 2008. - № 1. - С. 18-27.Пылаева О.А., Воронкова К.В., Холин А.А. Риск суицидального поведения при эпилепсии. Роль антиэпилептической терапии (обзор литературы) // Вестник эпилептологии. - 2008. - № 1. - С. 18-27.11. Abraham G. Topiramate-induced suicidality // Can J Psychiatry. - 2003. - V. 48(2). - P. 127-8.Abraham G. Topiramate-induced suicidality // Can J Psychiatry. - 2003. - V. 48(2). - P. 127-8.12. Abdoh M., Mersfelder T.L., Melgar T.A. Psychosis Induced by Zonisamide: a Case Report and Review of the Literature // Am J Ther. - 2011 Oct 17. [Epub ahead of print].Abdoh M., Mersfelder T.L., Melgar T.A. Psychosis Induced by Zonisamide: a Case Report and Review of the Literature // Am J Ther. - 2011 Oct 17. [Epub ahead of print].13. Akman C.I., Goodkin H.P., Rogers D.P., Riviello J.J.Jr. Visual hallucinations associated with zonisamide // Pharmacotherapy. - 2003. - V. 23(1). - P. 93-6.Akman C.I., Goodkin H.P., Rogers D.P., Riviello J.J.Jr. Visual hallucinations associated with zonisamide // Pharmacotherapy. - 2003. - V. 23(1). - P. 93-6.14. Alvarez N. Barbiturates in the treatment of epilepsy in people with intellectual disability // J Intellect Disabil Res. - 1998. - V. 42 (Suppl 1). - P. 16-23.Alvarez N. Barbiturates in the treatment of epilepsy in people with intellectual disability // J Intellect Disabil Res. - 1998. - V. 42 (Suppl 1). - P. 16-23.15. Andermann L.F. et al. Psychosis after resection of ganglioglioma or DNET: evidence for an association // Epilepsia. - 1999. - V.40/1. - P. 83-87.Andermann L.F. et al. Psychosis after resection of ganglioglioma or DNET: evidence for an association // Epilepsia. - 1999. - V.40/1. - P. 83-87.16. Andersohn F., Schade R., Willich S.N, Garbe E. Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior // Neurology. - 2010. - V. 75. - P. 335-40.Andersohn F., Schade R., Willich S.N, Garbe E. Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior // Neurology. - 2010. - V. 75. - P. 335-40.17. Arana A., Wentworth C.E., Ayuso-Mateos J.L., Arellano F.M. Suicide-related events in patients treated with antiepileptic drugs // N Engl J Med. - 2010. - V. 363(6). - P. 542-51.Arana A., Wentworth C.E., Ayuso-Mateos J.L., Arellano F.M. Suicide-related events in patients treated with antiepileptic drugs // N Engl J Med. - 2010. - V. 363(6). - P. 542-51.18. Arzimanoglou A. Treatment options in pediatric epilepsy syndromes // Epileptic disorders. - 2002. - V. 3. - Р. 217-225.Arzimanoglou A. Treatment options in pediatric epilepsy syndromes // Epileptic disorders. - 2002. - V. 3. - Р. 217-225.19. Bagary M. Epilepsy, antiepileptic drugs and suicidality // Curr Opin Neurol. - 2011. - V. 24(2). - P. 177-82.Bagary M. Epilepsy, antiepileptic drugs and suicidality // Curr Opin Neurol. - 2011. - V. 24(2). - P. 177-82.20. Barabas G., Matthews W.S. Barbiturate anticonvulsants as a cause of severe depression // Pediatrics. - 1988. - V. 82 - P. 284.Barabas G., Matthews W.S. Barbiturate anticonvulsants as a cause of severe depression // Pediatrics. - 1988. - V. 82 - P. 284.21. Barraclough В.M. The suicide rate of epilepsy // Acta Psychiatr Scand. - 1987. - V. 76. - P. 339-45.Barraclough В.M. The suicide rate of epilepsy // Acta Psychiatr Scand. - 1987. - V. 76. - P. 339-45.22. Bell G.S., Mula M., Sander J.W. Suicidality in people taking antiepileptic drugs: What is the evidence? // CNS Drugs. - 2009. - V. 23(4). - P. 281-92.Bell G.S., Mula M., Sander J.W. Suicidality in people taking antiepileptic drugs: What is the evidence? // CNS Drugs. - 2009. - V. 23(4). - P. 281-92.23. Bell G.S., Sander J.W. Suicide and epilepsy // Curr Opin Neurol. - 2009. - V. 22(2). - P. 174-8.Bell G.S., Sander J.W. Suicide and epilepsy // Curr Opin Neurol. - 2009. - V. 22(2). - P. 174-8.24. Ben-Menachem E. Levetiracetam: treatment in epilepsy // Expert Opin Pharmacother. - 2003. - V. 4(11). - P. 2079-88.Ben-Menachem E. Levetiracetam: treatment in epilepsy // Expert Opin Pharmacother. - 2003. - V. 4(11). - P. 2079-88.25. Born C., Dittmann S., Post R.M., Grunze H. Newer prophylactic agents for bipolar disorder and their influence on suicidality // Arch Suicide Res. - 2005. - V. 9(3) - P. 301-6.Born C., Dittmann S., Post R.M., Grunze H. Newer prophylactic agents for bipolar disorder and their influence on suicidality // Arch Suicide Res. - 2005. - V. 9(3) - P. 301-6.26. Boro A., Haut S. Medical comorbidities in the treatment of epilepsy // Epilepsy Behav. - 2003. - V. 4 (Suppl 2). - P. 2-12.Boro A., Haut S. Medical comorbidities in the treatment of epilepsy // Epilepsy Behav. - 2003. - V. 4 (Suppl 2). - P. 2-12.27. Brent D.A., Crumrine P.K., Varma R., et al. Phenobarbital treatment and major depressive disorder in children with epilepsy // Pediatrics. - 1987. - V. 80 - P. 909-917.Brent D.A., Crumrine P.K., Varma R., et al. Phenobarbital treatment and major depressive disorder in children with epilepsy // Pediatrics. - 1987. - V. 80 - P. 909-917.28. Brodie M.J., Johnson F.N. Carbamazepine in the treatment of seizure disorders: efficacy, pharmacokinetics and adverse event profile // Rev. Contemp. Pharmacother. - 1997. - V.8. - P.87-122.Brodie M.J., Johnson F.N. Carbamazepine in the treatment of seizure disorders: efficacy, pharmacokinetics and adverse event profile // Rev. Contemp. Pharmacother. - 1997. - V.8. - P.87-122.29. Buljan R., Santic A.M. Suicide attempts in hospital-treated epilepsy patients // Acta Clin Croat. - 2011. - V. 50(4). - P. 485-90.Buljan R., Santic A.M. Suicide attempts in hospital-treated epilepsy patients // Acta Clin Croat. - 2011. - V. 50(4). - P. 485-90.30. Chaytor N., Ciechanowski P., Miller J.W., Fraser R., Russo J., Unutzer J., Gilliam F. Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy // Epilepsy Behav. - 2011. - V. 20(3). - P. 545-9.Chaytor N., Ciechanowski P., Miller J.W., Fraser R., Russo J., Unutzer J., Gilliam F. Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy // Epilepsy Behav. - 2011. - V. 20(3). - P. 545-9.31. Chatzistefanidis D., Karvouni E., Kyritsis A.P., Markoula S. First case of lacosamide-induced psychosis // Clin Neuropharmacol. - 2013. - V. 36(1). - P. 27-8.Chatzistefanidis D., Karvouni E., Kyritsis A.P., Markoula S. First case of lacosamide-induced psychosis // Clin Neuropharmacol. - 2013. - V. 36(1). - P. 27-8.32. Chien J. Ethosuximide-induced mania in a 10-year-old boy // Epilepsy Behav. - 2011. - V. 21(4). - P. 483-5.Chien J. Ethosuximide-induced mania in a 10-year-old boy // Epilepsy Behav. - 2011. - V. 21(4). - P. 483-5.33. Christensen J., Vestergaard M., Mortensen P.B., Sidenius P., Agerbo E. Epilepsy and risk of suicide: a populationbased case-control study // Lancet Neurol. - 2007. - V. 6(8). - P. 693-8.Christensen J., Vestergaard M., Mortensen P.B., Sidenius P., Agerbo E. Epilepsy and risk of suicide: a populationbased case-control study // Lancet Neurol. - 2007. - V. 6(8). - P. 693-8.34. Christman D.S., Faubion M.D. Suicide attempt following initiation of topiramate // Am J Psychiatry. - 2007. - V. 164(4). - P. 682-3.Christman D.S., Faubion M.D. Suicide attempt following initiation of topiramate // Am J Psychiatry. - 2007. - V. 164(4). - P. 682-3.35. Coppola G., Caliendo G., Terracciano M.M., Buono S., Pellegrino L., Pascotto A. Topiramate in refractory partialonset seizures in children, adolescents and young adults: a multicentric open trial // Epilepsy Res. - 2001. - V.43. - № 3. - P.255-60.Coppola G., Caliendo G., Terracciano M.M., Buono S., Pellegrino L., Pascotto A. Topiramate in refractory partialonset seizures in children, adolescents and young adults: a multicentric open trial // Epilepsy Res. - 2001. - V.43. - № 3. - P.255-60.36. Cramer J.A., De Rue K., Devinsky O., Edrich P., Trimble M.R. A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials // Epilepsy Behav. - 2003. - V. 4(2). - P. 124-32.Cramer J.A., De Rue K., Devinsky O., Edrich P., Trimble M.R. A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials // Epilepsy Behav. - 2003. - V. 4(2). - P. 124-32.37. Donati F., Gobbi G., Campistol J., Rapatz G., Daehler M., Sturm Y., Aldenkamp A.P.; on behalf of The Oxcarbazepine Cognitive Study Group. The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures // Seizure. - 2007 Jun 15.Donati F., Gobbi G., Campistol J., Rapatz G., Daehler M., Sturm Y., Aldenkamp A.P.; on behalf of The Oxcarbazepine Cognitive Study Group. The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures // Seizure. - 2007 Jun 15.38. Dudra-Jastrzebska M., Andres-Mach M.M., Luszczki J.J., Czuczwar S.J. Mood disorders in patients with epilepsy // Pharmacol Rep. - 2007. - V. 59(4). - P. 369-78.Dudra-Jastrzebska M., Andres-Mach M.M., Luszczki J.J., Czuczwar S.J. Mood disorders in patients with epilepsy // Pharmacol Rep. - 2007. - V. 59(4). - P. 369-78.39. Fountoulakis K.N., Gonda X., Samara M., Siapera M., Karavelas V., Ristic D.I., Iacovides A. Antiepileptic drugs and suicidality // J Psychopharmacol. - 2012. - V. 26(11). - P. 1401-7.Fountoulakis K.N., Gonda X., Samara M., Siapera M., Karavelas V., Ristic D.I., Iacovides A. Antiepileptic drugs and suicidality // J Psychopharmacol. - 2012. - V. 26(11). - P. 1401-7.40. Gibbons R.D., Hur K., Brown C.H., Mann J.J. Gabapentin and suicide attempts // Pharmacoepidemiol Drug Saf. - 2010. - V. 19(12). - P. 1241-7.Gibbons R.D., Hur K., Brown C.H., Mann J.J. Gabapentin and suicide attempts // Pharmacoepidemiol Drug Saf. - 2010. - V. 19(12). - P. 1241-7.41. Givon L., Porter S., Padmanabhan B., Goren J., Cohen P.A. Levetiracetam, seizures, and suicidality // Harv Rev Psychiatry. - 2011. - V. 19(1). - P. 47-55.Givon L., Porter S., Padmanabhan B., Goren J., Cohen P.A. Levetiracetam, seizures, and suicidality // Harv Rev Psychiatry. - 2011. - V. 19(1). - P. 47-55.42. Glauser T.A. Behavioral and psychiatric adverse events associated with antiepileptic drugs commonly used in pediatric patients // J Child Neurol. - 2004. - V.19 Suppl 1. - P.25-38.Glauser T.A. Behavioral and psychiatric adverse events associated with antiepileptic drugs commonly used in pediatric patients // J Child Neurol. - 2004. - V.19 Suppl 1. - P.25-38.43. Guerrini R. Valproate as a mainstay of therapy for pediatric epilepsy // Paediatr Drugs. - 2006. - V. 8(2). - P. 113-129.Guerrini R. Valproate as a mainstay of therapy for pediatric epilepsy // Paediatr Drugs. - 2006. - V. 8(2). - P. 113-129.44. Hara E., Akanuma N., Adachi N., Hara K., Koutroumanidis M. Suicide attempts in adult patients with idiopathic generalized epilepsy // Psychiatry Clin Neurosci. - 2009. - V. 63(2). - P. 225-9.Hara E., Akanuma N., Adachi N., Hara K., Koutroumanidis M. Suicide attempts in adult patients with idiopathic generalized epilepsy // Psychiatry Clin Neurosci. - 2009. - V. 63(2). - P. 225-9.45. Harbord M.G. Significant anticonvulsant side-effects in children and adolescents // J-Clin-Neurosci. - 2000. - V.7. - №3. - P.213-216.Harbord M.G. Significant anticonvulsant side-effects in children and adolescents // J-Clin-Neurosci. - 2000. - V.7. - №3. - P.213-216.46. Hecimovic H., Salpekar J., Kanner A.M., Barry J.J. Suicidality and epilepsy: a neuropsychobiological perspective // Epilepsy Behav. - 2011. - V. 22(1). - P. 77-84.Hecimovic H., Salpekar J., Kanner A.M., Barry J.J. Suicidality and epilepsy: a neuropsychobiological perspective // Epilepsy Behav. - 2011. - V. 22(1). - P. 77-84.47. Hecimovic H., Santos J.M., Carter J., Attarian H.P., Fessler A.J., Vahle V., Gilliam F. Depression but not seizure factors or quality of life predicts suicidality in epilepsy // Epilepsy Behav. - 2012. - V. 24(4). - P. 426-9.Hecimovic H., Santos J.M., Carter J., Attarian H.P., Fessler A.J., Vahle V., Gilliam F. Depression but not seizure factors or quality of life predicts suicidality in epilepsy // Epilepsy Behav. - 2012. - V. 24(4). - P. 426-9.48. Hesdorffer D.C., Berg A.T., Kanner A.M. An update on antiepileptic drugs and suicide: are there definitive answers yet? // Epilepsy Curr. - 2010. - V. 10(6). - P. 137-45.Hesdorffer D.C., Berg A.T., Kanner A.M. An update on antiepileptic drugs and suicide: are there definitive answers yet? // Epilepsy Curr. - 2010. - V. 10(6). - P. 137-45.49. Hesdorffer D.C., French J.A., Posner K., DiVentura B., Pollard J.R., Sperling M.R., Harden C.L., Krauss G.L., Kanner A.M. Suicidal ideation and behavior screening in intractable focal epilepsy eligible for drug trials // Epilepsia. - 2013. - V. 54(5). - P. 879-87.Hesdorffer D.C., French J.A., Posner K., DiVentura B., Pollard J.R., Sperling M.R., Harden C.L., Krauss G.L., Kanner A.M. Suicidal ideation and behavior screening in intractable focal epilepsy eligible for drug trials // Epilepsia. - 2013. - V. 54(5). - P. 879-87.50. Hirose M., Yokoyama H., Haginoya K., Iinuma K. A five-year-old girl with epilepsy showing forced normalization due to zonisamide // No To Hattatsu. - 2003. - V. 35(3). - P. 259-63.Hirose M., Yokoyama H., Haginoya K., Iinuma K. A five-year-old girl with epilepsy showing forced normalization due to zonisamide // No To Hattatsu. - 2003. - V. 35(3). - P. 259-63.51. Jones J.E., Hermann B.P., Barry J.J., Gilliam F.G., Kanner A.M., Meador K.J. Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsy // Epilepsy Behav. - 2003. - Suppl 3. - P. 31-8.Jones J.E., Hermann B.P., Barry J.J., Gilliam F.G., Kanner A.M., Meador K.J. Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsy // Epilepsy Behav. - 2003. - Suppl 3. - P. 31-8.52. Kalinin V.V. Suicidality and antiepileptic drugs: is there a link? // Drug Saf. - 2007. - V. 30(2). - P. 123-42.Kalinin V.V. Suicidality and antiepileptic drugs: is there a link? // Drug Saf. - 2007. - V. 30(2). - P. 123-42.53. Kalinin V.V., Polyanskiy D.A. Gender differences in risk factors of suicidal behavior in epilepsy patients with a diagnosis of Major Depression // Epilepsy Behav. - 2005. - V. 6(3). - P. 424-9.Kalinin V.V., Polyanskiy D.A. Gender differences in risk factors of suicidal behavior in epilepsy patients with a diagnosis of Major Depression // Epilepsy Behav. - 2005. - V. 6(3). - P. 424-9.54. Kanner A.M. Suicidality and epilepsy: a complex relationship that remains misunderstood and underestimated // Epilepsy Curr. - 2009. - V. 9(3). - P. 63-6.Kanner A.M. Suicidality and epilepsy: a complex relationship that remains misunderstood and underestimated // Epilepsy Curr. - 2009. - V. 9(3). - P. 63-6.55. Kanner A.M., Wuu J., Faught E., Tatum W.O. 4th, Fix A, French JA; The PADS Investigators. A past psychiatric history may be a risk factor for topiramate-related psychiatric and cognitive adverse events // Epilepsy Behav. - 2003. - V. 4(5). - P.548-52.Kanner A.M., Wuu J., Faught E., Tatum W.O. 4th, Fix A, French JA; The PADS Investigators. A past psychiatric history may be a risk factor for topiramate-related psychiatric and cognitive adverse events // Epilepsy Behav. - 2003. - V. 4(5). - P.548-52.56. Kanner A.M., Schachter S.C., Barry J.J., Hersdorffer D.C., Mula M., Trimble M., Hermann B., Ettinger A.E., Dunn D., Caplan R., Ryvlin P., Gilliam F. Depression and epilepsy, pain and psychogenic non-epileptic seizures: clinical and therapeutic perspectives // Epilepsy Behav. - 2012. - V. 24(2). - P. 169-81.Kanner A.M., Schachter S.C., Barry J.J., Hersdorffer D.C., Mula M., Trimble M., Hermann B., Ettinger A.E., Dunn D., Caplan R., Ryvlin P., Gilliam F. Depression and epilepsy, pain and psychogenic non-epileptic seizures: clinical and therapeutic perspectives // Epilepsy Behav. - 2012. - V. 24(2). - P. 169-81.57. Kaufman K.R. Antiepileptic drugs in the treatment of psychiatric disorders // Epilepsy Behav. - 2011. - V. 21(1). - P. 1-11.Kaufman K.R. Antiepileptic drugs in the treatment of psychiatric disorders // Epilepsy Behav. - 2011. - V. 21(1). - P. 1-11.58. Kaufman K.R., Struck P.J. Activation of suicidal ideation with adjunctive rufinamide in bipolar disorder // Epilepsy Behav. - 2011. - V. 20(2). - P. 386-9.Kaufman K.R., Struck P.J. Activation of suicidal ideation with adjunctive rufinamide in bipolar disorder // Epilepsy Behav. - 2011. - V. 20(2). - P. 386-9.59. Kaufman K.R., Struck P.J. Psychogenic nonepileptic seizures and suicidal behavior on a video/EEG telemetry unit: the need for psychiatric assessment and screening for suicide risk // Epilepsy Behav. - 2010. - V. 19(4). - P. 656-9.Kaufman K.R., Struck P.J. Psychogenic nonepileptic seizures and suicidal behavior on a video/EEG telemetry unit: the need for psychiatric assessment and screening for suicide risk // Epilepsy Behav. - 2010. - V. 19(4). - P. 656-9.60. Kellinghaus C. Reversible suicidal ideation after exposure to lacosamide // Seizure. - 2013 Jan 25. doi:pii: S1059-1311(13)00008-3. 10.1016/j.seizure.2013.01.007.Kellinghaus C. Reversible suicidal ideation after exposure to lacosamide // Seizure. - 2013 Jan 25. doi:pii: S1059-1311(13)00008-3. 10.1016/j.seizure.2013.01.007.61. Koch-Stoecker S., Schmitz B., Kanner A.M. Treatment of postsurgical psychiatric complications // Epilepsia. - 2013. - V. 54 Suppl 1. - P. 46-52.Koch-Stoecker S., Schmitz B., Kanner A.M. Treatment of postsurgical psychiatric complications // Epilepsia. - 2013. - V. 54 Suppl 1. - P. 46-52.62. Kwon O.Y., Park S.P. Frequency of affective symptoms and their psychosocial impact in Korean people with epilepsy: a survey at two tertiary care hospitals // Epilepsy Behav. - 2013. - V. 26(1). - P. 51-6.Kwon O.Y., Park S.P. Frequency of affective symptoms and their psychosocial impact in Korean people with epilepsy: a survey at two tertiary care hospitals // Epilepsy Behav. - 2013. - V. 26(1). - P. 51-6.63. Landolt H. Die Bedeutung der EEG fur die Behandlung der Epilepsie. Tagung. - Dtsch. EEG-Ges. Berlin,1956.Landolt H. Die Bedeutung der EEG fur die Behandlung der Epilepsie. Tagung. - Dtsch. EEG-Ges. Berlin,1956.64. Levinsohn P.M. Safety and tolerability of topiramate in children// J Child Neurol. - 2000. - V.15. - P. 22-26.Levinsohn P.M. Safety and tolerability of topiramate in children// J Child Neurol. - 2000. - V.15. - P. 22-26.65. Levinson D.F., Devinsky O. Psychiatric adverse events during vigabatrin therapy // Neurology. - 1999. - V. 53(7). - P. 1503-11.Levinson D.F., Devinsky O. Psychiatric adverse events during vigabatrin therapy // Neurology. - 1999. - V. 53(7). - P. 1503-11.66. Lim H.W., Song H.S., Hwang Y.H., Lee H.W., Suh C.K., Park S.P., Kwon S.H. Predictors of suicidal ideation in people with epilepsy living in Korea // J Clin Neurol. - 2010. - V. 6(2). - P. 81-8.Lim H.W., Song H.S., Hwang Y.H., Lee H.W., Suh C.K., Park S.P., Kwon S.H. Predictors of suicidal ideation in people with epilepsy living in Korea // J Clin Neurol. - 2010. - V. 6(2). - P. 81-8.67. Machado R.A., Espinosa A.G., Melendrez D., Gonzalez Y.R., Garc?a VF, Rodr?guez Y.Q. Suicidal risk and suicide attempts in people treated with antiepileptic drugs for epilepsy // Seizure. - 2011. - V. 20(4). - P. 280-4.Machado R.A., Espinosa A.G., Melendrez D., Gonzalez Y.R., Garc?a VF, Rodr?guez Y.Q. Suicidal risk and suicide attempts in people treated with antiepileptic drugs for epilepsy // Seizure. - 2011. - V. 20(4). - P. 280-4.68. Mago R., Huege S., Ahuja N., Kunkel E.J. Zonisamide-induced suicidal ideation // Psychosomatics. - 2006. - V. 47(1). - P. 68-9.Mago R., Huege S., Ahuja N., Kunkel E.J. Zonisamide-induced suicidal ideation // Psychosomatics. - 2006. - V. 47(1). - P. 68-9.69. Mazza M., Orsucci F., De Risio S., Bria P., Mazza S. Epilepsy and depression: risk factors for suicide? // Clin Ter. - 2004. - V. 155(10). - P. 425-7.Mazza M., Orsucci F., De Risio S., Bria P., Mazza S. Epilepsy and depression: risk factors for suicide? // Clin Ter. - 2004. - V. 155(10). - P. 425-7.70. Mula M., Sander J.W. Negative effects of antiepileptic drugs on mood in patients with epilepsy // Drug Saf. - 2007. - V. 30(7). - P. 555-67.Mula M., Sander J.W. Negative effects of antiepileptic drugs on mood in patients with epilepsy // Drug Saf. - 2007. - V. 30(7). - P. 555-67.71. Mula M., Sander J.W. Suicidal ideation in epilepsy and levetiracetam therapy // Epilepsy Behav. - 2007. - V. 11(1). - P. 130-2.Mula M., Sander J.W. Suicidal ideation in epilepsy and levetiracetam therapy // Epilepsy Behav. - 2007. - V. 11(1). - P. 130-2.72. Mula M., Trimble M.R., Lhatoo S.D., Sander J.W. Topiramate and psychiatric adverse events in patients with epilepsy // Epilepsia. - 2003. - V. 44(5). - P. 659-63.Mula M., Trimble M.R., Lhatoo S.D., Sander J.W. Topiramate and psychiatric adverse events in patients with epilepsy // Epilepsia. - 2003. - V. 44(5). - P. 659-63.73. Mula M., Trimble M.R., Sander J.W. Psychiatric adverse events in patients with epilepsy and learning disabilities taking levetiracetam // Seizure. - 2004. - V.13(1) - P.55-7.Mula M., Trimble M.R., Sander J.W. Psychiatric adverse events in patients with epilepsy and learning disabilities taking levetiracetam // Seizure. - 2004. - V.13(1) - P.55-7.74. Mula M., Trimble M.R., Sander J.W. The role of hippocampal sclerosis in topiramate-related depression and cognitive deficits in people with epilepsy // Epilepsia. - 2003. - V.44(12) - P. 1573-7.Mula M., Trimble M.R., Sander J.W. The role of hippocampal sclerosis in topiramate-related depression and cognitive deficits in people with epilepsy // Epilepsia. - 2003. - V.44(12) - P. 1573-7.75. Mula M., Bell G.S., Sander J.W. Assessing suicidal risk with antiepileptic drugs // Neuropsychiatr Dis Treat. - 2010. - Oct 5;6. - V. 613-8.Mula M., Bell G.S., Sander J.W. Assessing suicidal risk with antiepileptic drugs // Neuropsychiatr Dis Treat. - 2010. - Oct 5;6. - V. 613-8.76. Mula M., Bell G.S., Sander J.W. Suicidality in epilepsy and possible effects of antiepileptic drugs // Curr Neurol Neurosci Rep. - 2010. - V. 10(4). - P. 327-32.Mula M., Bell G.S., Sander J.W. Suicidality in epilepsy and possible effects of antiepileptic drugs // Curr Neurol Neurosci Rep. - 2010. - V. 10(4). - P. 327-32.77. Mula M., Hesdorffer D.C. Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence // Drug Healthc Patient Saf. - 2011. - V. 3. - P. 15-20.Mula M., Hesdorffer D.C. Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence // Drug Healthc Patient Saf. - 2011. - V. 3. - P. 15-20.78. Mula M., Kanner A.M., Schmitz B., Schachter S. Antiepileptic drugs and suicidality: an expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology // Epilepsia. - 2013. - V. 54(1). - P. 199-203.Mula M., Kanner A.M., Schmitz B., Schachter S. Antiepileptic drugs and suicidality: an expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology // Epilepsia. - 2013. - V. 54(1). - P. 199-203.79. Neuwirth M., Saracz J., Hegyi M., Paraicz E., Kollar K., Moser J., Rosdy B., Herczegfalvi A., Fogarasi A. Experience with levetiracetam in childhood epilepsy // Ideggyogy Sz. - 2006. - V.59(5-6). - P.179-82.Neuwirth M., Saracz J., Hegyi M., Paraicz E., Kollar K., Moser J., Rosdy B., Herczegfalvi A., Fogarasi A. Experience with levetiracetam in childhood epilepsy // Ideggyogy Sz. - 2006. - V.59(5-6). - P.179-82.80. Nuhu F.T., Lasisi M.D., Yusuf A.J., Aremu S.B. Suicide risk among adults with epilepsy in Kaduna, Nigeria // Gen Hosp Psychiatry. - 2013 Jun 11. pii: S0163-8343(13)00133-3. doi: 10.1016/j.genhosppsych.2013.04.012. [Epub ahead of print]Nuhu F.T., Lasisi M.D., Yusuf A.J., Aremu S.B. Suicide risk among adults with epilepsy in Kaduna, Nigeria // Gen Hosp Psychiatry. - 2013 Jun 11. pii: S0163-8343(13)00133-3. doi: 10.1016/j.genhosppsych.2013.04.012. [Epub ahead of print]81. Okubadejo N.U., Danesi M.A., Aina O.F., Ojini F.I., Adeyemi J.D., Olorunshola D.A. Prospective case-control study of interictal depression and suicidal ideation in Nigerians with epilepsy // Niger Postgrad Med J. - 2007. - V.14(3). - P. 204-8.Okubadejo N.U., Danesi M.A., Aina O.F., Ojini F.I., Adeyemi J.D., Olorunshola D.A. Prospective case-control study of interictal depression and suicidal ideation in Nigerians with epilepsy // Niger Postgrad Med J. - 2007. - V.14(3). - P. 204-8.82. Olesen J.B., Hansen P.R., Erdal J., Abildstr?m S.Z., Weeke P., Fosbol E.L., Poulsen H.E., Gislason G.H. Antiepileptic drugs and risk of suicide: a nationwide study // Pharmacoepidemiol Drug Saf. - 2010. - V. 19(5). - P. 518-24.Olesen J.B., Hansen P.R., Erdal J., Abildstr?m S.Z., Weeke P., Fosbol E.L., Poulsen H.E., Gislason G.H. Antiepileptic drugs and risk of suicide: a nationwide study // Pharmacoepidemiol Drug Saf. - 2010. - V. 19(5). - P. 518-24.83. Patorno E., Bohn R.L., Wahl P.M., Avorn J., Patrick A.R., Liu J., Schneeweiss S. Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death // JAMA. - 2010. - V. 303(14). - P. 1401-9.Patorno E., Bohn R.L., Wahl P.M., Avorn J., Patrick A.R., Liu J., Schneeweiss S. Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death // JAMA. - 2010. - V. 303(14). - P. 1401-9.84. Pompili M., Girardi P., Ruberto A., Tatarelli R. Suicide in the epilepsies: a meta-analytic investigation of 29 cohorts // Epilepsy Behav. - 2005. - V. 7(2) - P. 305-10.Pompili M., Girardi P., Ruberto A., Tatarelli R. Suicide in the epilepsies: a meta-analytic investigation of 29 cohorts // Epilepsy Behav. - 2005. - V. 7(2) - P. 305-10.85. Pompili M., Baldessarini R.J. Epilepsy: Risk of suicidal behavior with antiepileptic drugs // Nat Rev Neurol. - 2010. - V. 6(12). - P. 651-3.Pompili M., Baldessarini R.J. Epilepsy: Risk of suicidal behavior with antiepileptic drugs // Nat Rev Neurol. - 2010. - V. 6(12). - P. 651-3.86. Pompili M., Tatarelli R., Girardi P., Tondo L., Baldessarini R.J. Suicide risk during anticonvulsant treatment // Pharmacoepidemiol Drug Saf. - 2010. - V. 19(5). - P. 525-8.Pompili M., Tatarelli R., Girardi P., Tondo L., Baldessarini R.J. Suicide risk during anticonvulsant treatment // Pharmacoepidemiol Drug Saf. - 2010. - V. 19(5). - P. 525-8.87. Quiske A. et al. Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis. Epilepsy res. - 2000. - V. 39 - P. 121-125.Quiske A. et al. Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis. Epilepsy res. - 2000. - V. 39 - P. 121-125.88. Redden L., Pritchett Y., Robieson W., Kovacs X., Garofalo M., Tracy K., Saltarelli M. Suicidality and divalproex sodium: analysis of controlled studies in multiple indications // Ann Gen Psychiatry. - 2011. - V. 10(1):1.Redden L., Pritchett Y., Robieson W., Kovacs X., Garofalo M., Tracy K., Saltarelli M. Suicidality and divalproex sodium: analysis of controlled studies in multiple indications // Ann Gen Psychiatry. - 2011. - V. 10(1):1.89. Sachdeo R.C. еt al. Topiramate monotherapy for partial onset seizures // Epilepsia. - 1997. - V.38. - P.294-300.Sachdeo R.C. еt al. Topiramate monotherapy for partial onset seizures // Epilepsia. - 1997. - V.38. - P.294-300.90. Shneker B.F., Cios J.S., Elliott J.O. Suicidality, depression screening, and antiepileptic drugs: reaction to the FDA alert // Neurology. - 2009. - V. 72(11). - P. 987-91.Shneker B.F., Cios J.S., Elliott J.O. Suicidality, depression screening, and antiepileptic drugs: reaction to the FDA alert // Neurology. - 2009. - V. 72(11). - P. 987-91.91. Shorvon S.D. Safety of Topiramate: Adverse events and relationships to dosing // Epilepsia. - 1996. - V.37. - № 2. - P. 18-22.Shorvon S.D. Safety of Topiramate: Adverse events and relationships to dosing // Epilepsia. - 1996. - V.37. - № 2. - P. 18-22.92. Stefanello S., Marin-Leon L., Fernandes P.T., Li L.M., Botega N.J. Psychiatric comorbidity and suicidal behavior in epilepsy: a community-based case-control study // Epilepsia. - 2010. - V. 51(7). - P. 1120-5.Stefanello S., Marin-Leon L., Fernandes P.T., Li L.M., Botega N.J. Psychiatric comorbidity and suicidal behavior in epilepsy: a community-based case-control study // Epilepsia. - 2010. - V. 51(7). - P. 1120-5.93. Stefanello S., Marin-Leon L., Fernandes P.T., Li L.M., Botega N.J. Depression and anxiety in a community sample with epilepsy in Brazil // Arq Neuropsiquiatr. - 2011. - V. 69(2B). - P. 342-8.Stefanello S., Marin-Leon L., Fernandes P.T., Li L.M., Botega N.J. Depression and anxiety in a community sample with epilepsy in Brazil // Arq Neuropsiquiatr. - 2011. - V. 69(2B). - P. 342-8.94. Stefanello S., Marin-Leon L., Fernandes P.T., Min L.L., Botega N.J. Suicidal thoughts in epilepsy: a communitybased study in Brazil // Epilepsy Behav. - 2010. - V. 17(4). - P. 483-8.Stefanello S., Marin-Leon L., Fernandes P.T., Min L.L., Botega N.J. Suicidal thoughts in epilepsy: a communitybased study in Brazil // Epilepsy Behav. - 2010. - V. 17(4). - P. 483-8.95. Trimble M.R., Cull C. Children of school age: The influence of antiepileptic drugs on behavior and intellect // Epilepsia. - 1988. - V. 29 (Suppl). - P. 15-19.Trimble M.R., Cull C. Children of school age: The influence of antiepileptic drugs on behavior and intellect // Epilepsia. - 1988. - V. 29 (Suppl). - P. 15-19.96. Trimble M.R., Schmitz B. Seizures, Affective Disorders and Anticonvulsant Drugs. - Clarus Press Ltd, Guildford, UK, 2002. - 199 p.Trimble M.R., Schmitz B. Seizures, Affective Disorders and Anticonvulsant Drugs. - Clarus Press Ltd, Guildford, UK, 2002. - 199 p.97. Trimble M.R. The psychosis of epilepsy. - New York: Raven Press, 1991.Trimble M.R. The psychosis of epilepsy. - New York: Raven Press, 1991.98. Trimble M.R., Cull C.A. Antiepileptic drugs, cognitive function, and behavior in children // Cleve Clin J Med. - 1989. - V.56. - Suppl 1. - P.140-146, discussion P147-149.Trimble M.R., Cull C.A. Antiepileptic drugs, cognitive function, and behavior in children // Cleve Clin J Med. - 1989. - V.56. - Suppl 1. - P.140-146, discussion P147-149.99. Uebelacker L.A., Weisberg R., Millman M., Yen S., Keller M. Prospective study of risk factors for suicidal behavior in individuals with anxiety disorders // Psychol Med. - 2013. - V. 43(7). - P. 1465-74.Uebelacker L.A., Weisberg R., Millman M., Yen S., Keller M. Prospective study of risk factors for suicidal behavior in individuals with anxiety disorders // Psychol Med. - 2013. - V. 43(7). - P. 1465-74.100. VanCott A.C., Cramer J.A., Copeland L.A., Zeber J.E., Steinman M.A., Dersh J.J., Glickman M.E., Mortensen E.M., Amuan M.E., Pugh M.J. Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital system // BMC Med. - 2010. - V. 8. - P. 4.VanCott A.C., Cramer J.A., Copeland L.A., Zeber J.E., Steinman M.A., Dersh J.J., Glickman M.E., Mortensen E.M., Amuan M.E., Pugh M.J. Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital system // BMC Med. - 2010. - V. 8. - P. 4.101. Wen X., Meador K.J., Loring D.W., Eisenschenk S., Segal R., Hartzema A.G. Is antiepileptic drug use related to depression and suicidal ideation among patients with epilepsy? // Epilepsy Behav. - 2010. - V. 19(3). - P. 494-500.Wen X., Meador K.J., Loring D.W., Eisenschenk S., Segal R., Hartzema A.G. Is antiepileptic drug use related to depression and suicidal ideation among patients with epilepsy? // Epilepsy Behav. - 2010. - V. 19(3). - P. 494-500.102. Wolf P. Acute behavioral symptomatology at disappearance of epileptiform EEG abnormality. Paradoxical or «forced» normalization//Adv. neurol. - 1991. - V.55. - P. 127-142.Wolf P. Acute behavioral symptomatology at disappearance of epileptiform EEG abnormality. Paradoxical or «forced» normalization//Adv. neurol. - 1991. - V.55. - P. 127-142.103. Wolf P., Trimble M.R. Biological antagonism and epileptic psychosis // British Journal of Psychiatry. - 1985. - V. 146. - P.272-276.Wolf P., Trimble M.R. Biological antagonism and epileptic psychosis // British Journal of Psychiatry. - 1985. - V. 146. - P.272-276.104. Wolf S.M., Forsythe A. Behavior disturbance, phenobarbital, and febrile seizures // Pediatrics. - 1978. - V.61(5). - P.728-31.Wolf S.M., Forsythe A. Behavior disturbance, phenobarbital, and febrile seizures // Pediatrics. - 1978. - V.61(5). - P.728-31.105. Yerevanian B.I., Koek R.J., Mintz J. Bipolar pharmacotherapy and suicidal behavior. Part I: Lithium, divalproex and carbamazepine // J Affect Disord. - 2007. - V. 103(1-3). - P. 5-11.Yerevanian B.I., Koek R.J., Mintz J. Bipolar pharmacotherapy and suicidal behavior. Part I: Lithium, divalproex and carbamazepine // J Affect Disord. - 2007. - V. 103(1-3). - P. 5-11.106. Yerevanian B.I., Koek R.J., Mintz J. Lithium, anticonvulsants and suicidal behavior in bipolar disorder // J Affect Disord. - 2003. - V. 73(3). - P. 223-8.Yerevanian B.I., Koek R.J., Mintz J. Lithium, anticonvulsants and suicidal behavior in bipolar disorder // J Affect Disord. - 2003. - V. 73(3). - P. 223-8.107. Zamani G., Mehdizadeh M., Sadeghi P. Attempt to suicide in young ages with epilepsy // Iran J Pediatr. - 2012. - V. 22(3). - P. 404-7.Zamani G., Mehdizadeh M., Sadeghi P. Attempt to suicide in young ages with epilepsy // Iran J Pediatr. - 2012. - V. 22(3). - P. 404-7.