Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press710.17650/2073-8803-2014-9-1-5-22ORIGINAL REPORTSОРИГИНАЛЬНЫЕ СТАТЬИAGGRAVATION OF EPILEPSY ON LEVETIRACETAM THERAPY: 28 CLINICAL OBSERVATIONS, RISK FACTORS AND POSSIBILITY OF PROPHYLACTICАггравация эпилепсии при терапии леветирацетамом: наблюдение 28 клинических случаев, факторы риска и профилактикаKholinA. A.ХолинА. А.
Russian Federation
drkholin@mail.ruFedonyukI. D.ФедонюкИ. Д.
Russian Federation
KolpakchiL. MКолпакчиЛ. М.
Russian Federation
Il`inaE. S.ИльинаЕ. С.
Russian Federation
MukhinK. Yu.МухинК. Ю.
Russian Federation
Department of Child Neurology, Neurosurgery and Medical Genetics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow Psycho-Neurology Department N 2, Russian Children Clinical Hospital, Ministry of Health of Russia, MoscowКафедра неврологии, нейрохирургии и медицинской генетики педиатрического факультета ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва отделение психоневрологии № 2 ФГБУ «Российская детская клиническая больница» Минздрава России, МоскваPsycho-Neurology Department N 2, Russian Children Clinical Hospital, Ministry of Health of Russia, Moscowотделение психоневрологии № 2 ФГБУ «Российская детская клиническая больница» Минздрава России, МоскваSvt. Luka’s Institute of Child Neurology & Epilepsy, MoscowООО «Институт детской неврологии и эпилепсии им. Святителя Луки», Москва15012014915221804201518042015Copyright ©; 2014, ABV-PressCopyright ©; 2014, АБВ-пресс2014ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/7

The authors had properly analyzed 28 clinical cases of epilepsy aggravation on levetiracetam therapy in pediatric patients receiving levetiracetam (n = 183). Risk of aggravation was 15,3 % (n = 28), including aggravation of epileptic status in 3,3 % of cases (n = 6). Levetiracetam could aggravate the following types of epileptic seizures: predominantly tonic spasms and myoclonic seizures, atypical absences with addition of negative epileptic myoclonus de novo, rarely – focal seizures and generalized tonic-clonic seizures and in some cases could aggravate status epilepticus of atypical absences, myoclonic, hemiconvulsive, tonic-autonomic and generalized tonic-clonic seizures. So, levetiracetam in population of infancy, early childhood and pre-school age children (before 7 years) must be used very carefully in consideration of potential risk of epilepsy aggravation.

Авторами подробно проанализировано 28 клинических случаев аггравации эпилепсии на фоне введения в терапию леветирацетама (кеппра, UCB) в наблюдаемой педиатрической популяции пациентов (n = 183). Частота аггравации составила 15,3 % (n = 28), включая возникновение эпилептического статуса в 3,3 % случаев (n = 6). Леветирацетам способен аггравировать следующие типы эпилептических приступов: тонические спазмы и миоклонические приступы, атипичные абсансы с присоединением негативного эпилептического миоклонуса de novo, реже – фокальные приступы и генерализованные тонико-клонические приступы. А также в отдельных случаях этот препарат способен аггравировать эпилептический статус атипичных абсансов, миоклонических гемиконвульсивных, тонико-вегетативных и генерализованных тонико-клонических приступов. Таким образом, леветирацетам в популяции детей младенческого, раннего детского и дошкольного возраста (до 7 лет) следует назначать с соблюдением мер предосторожности с учетом риска возможной аггравации

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