Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press43210.17650/2073-8803-2023-18-1-38-45REVIEWS AND LECTURESОБЗОРЫ И ЛЕКЦИИTreatment of epilepsy with mesenchymal stem cells: literature reviewЛечение эпилепсии мезенхимальными стволовыми клетками: обзор литературыhttps://orcid.org/0000-0002-8582-592XGamirovaR. G.ГамироваР. Г.
Russian Federation

Rimma Gabdulbarovna Gamirova

18 Kremlyovskaya St., Kazan 420008

Римма Габдульбаровна Гамирова

420008 Казань, ул. Кремлевская, 18

r-gamirov@mail.ruhttps://orcid.org/0000-0001-5151-7163ShaymardanovaA. A.ШаймардановаА. А.
Russian Federation

18 Kremlyovskaya St., Kazan 420008

420008 Казань, ул. Кремлевская, 18

https://orcid.org/0000-0003-4232-3994BarkovA. Yu.БарковА. Ю.
Russian Federation

23 Kropotkinskiy Pereulok, Moscow 119034

119034 Москва, Кропоткинский переулок, 23

https://orcid.org/0000-0002-9427-5739RizvanovA. A.РизвановА. А.
Russian Federation

18 Kremlyovskaya St., Kazan 420008

420008 Казань, ул. Кремлевская, 18

https://orcid.org/0000-0002-3362-8967ChulpanovaD. S.ЧулпановаД. С.
Russian Federation

18 Kremlyovskaya St., Kazan 420008

420008 Казань, ул. Кремлевская, 18

https://orcid.org/0000-0001-9152-2338MullagulovaA. I.МуллагуловаА. И.
Russian Federation

18 Kremlyovskaya St., Kazan 420008

420008 Казань, ул. Кремлевская, 18

https://orcid.org/0000-0002-8776-3662SolovyevaV. V.СоловьеваВ. В.
Russian Federation

18 Kremlyovskaya St., Kazan 420008

420008 Казань, ул. Кремлевская, 18

Kazan (Volga Region) Federal UniversityФГАОУ ВО «Казанский (Приволжский) федеральный университет»Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии им. В. П. Сербского» Минздрава России1501202318138452606202326062023Copyright ©; 2023, ABV-PressCopyright ©; 2023, АБВ-пресс2023ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/432

In the past few years, results from experimental and clinical studies have shown that inflammation can be both a consequence and a cause of epilepsy. Distinctive features of mesenchymal stem cells (MSCs) are their immunomodulatory and anti-inflammatory properties, which indicate promise in the field of epilepsy treatment.

The article presents a review on the preclinical and clinical use of MSCs in the treatment of epilepsy, and outlines the mechanism of MSCs therapeutic action of in this disease. The authors focused on the analysis of all available in the literature clinical cases of MSCs use in the treatment of epilepsy, as well as the effectiveness and undesirable effects of therapy. The use of MSCs indeed has a significant effect in reducing the number of seizures and has a positive effect on mental functions, however, at present, this method of therapy is not ready for widespread clinical use due to the short period of observation in clinical trials and increased risks of developing immunological and oncological complications in patients.

В последние несколько лет результаты экспериментальных и клинических исследований показали, что воспаление может быть как следствием, так и причиной эпилепсии. Отличительными особенностями мезенхимальных стволовых клеток (МСК) являются их иммуномодулирующие и противовоспалительные свойства, что свидетельствует о перспективах использования МСК в области лечения эпилепсии.

В статье представлен обзор литературы по доклиническому и клиническому применению МСК в лечении эпилепсии, изложен механизм лечебного действия МСК при данном заболевании. Авторы сделали акцент на анализе всех имеющихся в литературе клинических случаев применения МСК в лечении эпилепсии, а также на эффективности и нежелательных эффектах проведенной терапии. Использование МСК действительно обладает значительным эффектом в уменьшении количества приступов, положительно влияет на психические функции, однако в настоящее время данный метод терапии недостаточно готов к широкому клиническому применению в связи с коротким периодом наблюдения за пациентами в проведенных клинических испытаниях и повышенными рисками развития иммунологических и онкологических осложнений у пациентов.

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