Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press40610.17650/2073-8803-2022-17-3-55-62REVIEWS AND LECTURESОБЗОРЫ И ЛЕКЦИИSleep disorder in Angelman syndrome: causes, mechanisms and methods of correction. Literature reviewНарушение сна при синдроме Ангельмана: причины, механизмы и методы коррекции. Обзор литературыPsyanchinA. A.ПсянчинА. А.
Russian Federation

4 Lesnoy Proezd, Ufa 450071

450071 Уфа, Лесной проезд, 4

https://orcid.org/0000-0001-6125-0618BobylovaM. Yu.БобыловаМ. Ю.
Russian Federation

Mariya Yuryevna Bobylova 

5 Nagornaya St., Troitsk, Moscow 108842

9 Akad. Anokhina St., Moscow 119571

Мария Юрьевна Бобылова

108842 Москва, Троицк, ул. Нагорная, 5

119571 Москва, ул. Акад. Анохина, 9

mariya_bobylova@mail.ruYakupovT. Z.ЯкуповТ. З.
Russian Federation

5 Nagornaya St., Troitsk, Moscow 108842

9 Akad. Anokhina St., Moscow 119571

450071 Уфа, Лесной проезд, 4

Clinical Hospital “Mother and Child”Клинический госпиталь «Мать и Дитя»Svt. Luka’s Institute of Child Neurology and EpilepsyООО «Институт детской неврологии и эпилепсии им. Святителя Луки»Svt. Luka’s Institute of Pediatric and Adult Neurology and EpilepsyООО «Институт детской и взрослой неврологии и эпилепсии им. Святителя Луки»1507202217355621712202217122022Copyright ©; 2022, ABV-PressCopyright ©; 2022, АБВ-пресс2022ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/406

Sleep disorder is one of the prominent manifestations of Angelman syndrome. The exact causes are unknown and methods of correction are difficult. The literature review is devoted to studies of the pathogenesis of sleep disorders in Angelman syndrome (the effects of gene function in 15q11–q13 deletion, findings in polysomnography, video-EEG sleep monitoring, laboratory data), on the basis of which recommendations for the correction of dyssomnia, including methods of behavioral therapy, are given.

Нарушение сна является одним из основных проявлений синдрома Ангельмана. До настоящего времени нет точных данных о том, чем эти нарушения обусловлены, и их коррекция представляет сложную задачу. Обзор литературы посвящен исследованиям патогенеза нарушений сна при синдроме Ангельмана (влияниям функции генов при делеции 15q11–q13, находкам при полисомнографии, видеоэлектроэнцефалографическом мониторинге сна, данным лабораторных исследований), на основании которых даны рекомендации по коррекции диссомнии, в том числе методы поведенческой терапии.

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