<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Child Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Child Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Русский журнал детской неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-8803</issn><issn publication-format="electronic">2412-9178</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">40</article-id><article-id pub-id-type="doi">10.17650/2073-8803-2014-9-4-59-68</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">EFFICACY AND TOLERABILITY OF LACOSAMIDE (VIMPAT) FOR TREATMENT OF EPILEPSY IN ADULTS (A REVIEW)</article-title><trans-title-group xml:lang="ru"><trans-title>Эффективность и переносимость препарата лакосамид (Вимпат) в лечении эпилепсии у взрослых (обзор литературы)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pylaeva</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Пылаева</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mukhin</surname><given-names>K. Yu.</given-names></name><name xml:lang="ru"><surname>Мухин</surname><given-names>К. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>center@epileptologist.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mironov</surname><given-names>M. B.</given-names></name><name xml:lang="ru"><surname>Миронов</surname><given-names>М. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Svt. Luka's Institute of Child Neurology and Epilepsy, 6 Svetlaya St., Puchkovo Settlement, Troitsk, Moscow, 143396, Russia</institution></aff><aff><institution xml:lang="ru">ООО «Институт детской неврологии и эпилепсии им. Святителя Луки», Россия, 143396, Москва, Троицк, п. Пучково, ул. Светлая, 6</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2014</year></pub-date><volume>9</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>59</fpage><lpage>68</lpage><history><date date-type="received" iso-8601-date="2015-04-19"><day>19</day><month>04</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-04-19"><day>19</day><month>04</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, АБВ-пресс</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://rjdn.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://rjdn.abvpress.ru/jour/article/view/40">https://rjdn.abvpress.ru/jour/article/view/40</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>epilepsy</kwd><kwd>epilepsy resistant to therapy</kwd><kwd>focal seizures</kwd><kwd>adult patients</kwd><kwd>lacosamidе</kwd><kwd>action mechanism</kwd><kwd>pharmacokinetics</kwd><kwd>pharmacodynamics</kwd><kwd>efficacy</kwd><kwd>tolerability</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>эпилепсия</kwd><kwd>резистентная к терапии эпилепсия</kwd><kwd>фокальные приступы</kwd><kwd>взрослые пациенты</kwd><kwd>лакосамид</kwd><kwd>механизм действия</kwd><kwd>фармакокинетика</kwd><kwd>фармакодинамика</kwd><kwd>эффективность</kwd><kwd>переносимость</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Артемова И.Ю., Бадалян О.Л., Богомазова М.Л. и др. Опыт применения лакосамида при различных формах эпилепсии (результаты наблюдательного исследования в учреждениях амбулаторной сети городского здравоохранения г. Москвы. Эпилепсия и пароксизмальные состояния 2011;3(3):15–20. [Artyomova I.Yu., Badalyan O.L., Bogomazova M.L. et al. Experience of application of lacosamide with various forms of epilepsy (results of observation study in out-patient institutions of Municipal Health-Care Network of Moscow. Epilepsy and Paroxysmal States 2011;3(3):15–20].</mixed-citation><mixed-citation xml:lang="ru">Артемова И.Ю., Бадалян О.Л., Богомазова М.Л. и др. Опыт применения лакосамида при различных формах эпилепсии (результаты наблюдательного исследования в учреждениях амбулаторной сети городского здравоохранения г. Москвы. Эпилепсия и пароксизмальные состояния 2011;3(3):15–20. [Artyomova I.Yu., Badalyan O.L., Bogomazova M.L. et al. Experience of application of lacosamide with various forms of epilepsy (results of observation study in out-patient institutions of Municipal Health-Care Network of Moscow. Epilepsy and Paroxysmal States 2011;3(3):15–20].</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Воронкова К.В., Пылаева О.А., Федин А.И. Современные принципы лечения фокальных эпилепсий. Эпилепсия 2011;4(1):2–14. [Voronkova K.V., Pylaeva O.A., Fedin A.I. Modern principles of treatment of focal epilepsies. Epilepsy 2011;4(1):2–14].</mixed-citation><mixed-citation xml:lang="ru">Воронкова К.В., Пылаева О.А., Федин А.И. Современные принципы лечения фокальных эпилепсий. Эпилепсия 2011;4(1):2–14. [Voronkova K.V., Pylaeva O.A., Fedin A.I. Modern principles of treatment of focal epilepsies. Epilepsy 2011;4(1):2–14].</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Зенков Л.Р. Противоэпилептический препарат лакосамид (вимпат). Журнал неврологии и психиатрии им. С.С. Корсакова 2010;110(10):72–9. [Zenkov L.R. Antiepileptic drug lacosamide (vimpat). S.S. Korsakov Journal of Neurology and Psychiatrics 2010;110(10):72–9].</mixed-citation><mixed-citation xml:lang="ru">Зенков Л.Р. Противоэпилептический препарат лакосамид (вимпат). Журнал неврологии и психиатрии им. С.С. Корсакова 2010;110(10):72–9. [Zenkov L.R. Antiepileptic drug lacosamide (vimpat). S.S. Korsakov Journal of Neurology and Psychiatrics 2010;110(10):72–9].</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Мильчакова Л.Е., Гехт А.Б. Эффективность и безопасность нового противоэпилептического препарата лакосамид у больных фокальной эпилепсией (данные двойных слепых плацебоонтролируемых исследований). Журнал неврологии и психиатрии им. С.С. Корсакова 2010;110(3 выпуск 2):39–43. [Milchakova L.E., Gekht A.B. Efficacy and safety of the new antiepileptic drug lacosamide for patients with focal epilepsy (data of double blind placebo controlled studies). S.S. Korsakov Journal of Neurology and Psychiatrics 2010;110(3 issue 2):39–43].</mixed-citation><mixed-citation xml:lang="ru">Мильчакова Л.Е., Гехт А.Б. Эффективность и безопасность нового противоэпилептического препарата лакосамид у больных фокальной эпилепсией (данные двойных слепых плацебоонтролируемых исследований). Журнал неврологии и психиатрии им. С.С. Корсакова 2010;110(3 выпуск 2):39–43. [Milchakova L.E., Gekht A.B. Efficacy and safety of the new antiepileptic drug lacosamide for patients with focal epilepsy (data of double blind placebo controlled studies). S.S. Korsakov Journal of Neurology and Psychiatrics 2010;110(3 issue 2):39–43].</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Миронов М.Б., Мухин К.Ю., Пылаева О.А. Эффективность вимпата (лакосамид) у пациентки с резистентной формой криптогенной фокальной эпилепсии с фокальными аутомоторными и вторично-генерализованными судорожными приступами (описание случая). Русский журнал детской неврологии 2012;8(2):3–12. [Mironov M.B., Mukhin K.Yu., Pylaeva O.A. Efficacy of vimpat (lacosamide) in a patient with resistant form of cryptogenic focal epilepsy with focal automotoric and secondarily generalized seizures (case report). Russian Journal of Child Neurology 2012;8(2):3–12].</mixed-citation><mixed-citation xml:lang="ru">Миронов М.Б., Мухин К.Ю., Пылаева О.А. Эффективность вимпата (лакосамид) у пациентки с резистентной формой криптогенной фокальной эпилепсии с фокальными аутомоторными и вторично-генерализованными судорожными приступами (описание случая). Русский журнал детской неврологии 2012;8(2):3–12. [Mironov M.B., Mukhin K.Yu., Pylaeva O.A. Efficacy of vimpat (lacosamide) in a patient with resistant form of cryptogenic focal epilepsy with focal automotoric and secondarily generalized seizures (case report). Russian Journal of Child Neurology 2012;8(2):3–12].</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Мухин К.Ю., Петрухин А.С., Миронов М.Б. Эпилептические синдромы Диагностика и терапия (справочное руководство). М.: Системные решения, 2008. 224 с. [Mukhin K.Yu., Petrukhin A.S., Mironov M.B. Epileptic syndromes. Diagnostics and therapy (handbook). Moscow: Systemnye Resheniya, 2008. 224 .].</mixed-citation><mixed-citation xml:lang="ru">Мухин К.Ю., Петрухин А.С., Миронов М.Б. Эпилептические синдромы Диагностика и терапия (справочное руководство). М.: Системные решения, 2008. 224 с. [Mukhin K.Yu., Petrukhin A.S., Mironov M.B. Epileptic syndromes. Diagnostics and therapy (handbook). Moscow: Systemnye Resheniya, 2008. 224 .].</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Мухин К.Ю., Тысячина М.Д., Глухова Л.Ю., Фрейдкова Н.В. Клинический случай применения лакосамида (вимпат) в лечении резистентной формы симптоматической фокальной эпилепсии. Русский журнал детской неврологии 2011;6(2):37–42. [Mukhin K.Yu., Tysyachina M.D., Glukhova L.Yu.,</mixed-citation><mixed-citation xml:lang="ru">Мухин К.Ю., Тысячина М.Д., Глухова Л.Ю., Фрейдкова Н.В. Клинический случай применения лакосамида (вимпат) в лечении резистентной формы симптоматической фокальной эпилепсии. Русский журнал детской неврологии 2011;6(2):37–42. [Mukhin K.Yu., Tysyachina M.D., Glukhova L.Yu.,</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><mixed-citation>Freidkova N.V. Clinical case of application of lacosamide (vimpat) for treatment of resistant form of symptomatic focal epilepsy. Russian Journal of Child Neurology 2011;6(2):37–42].</mixed-citation></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">8. Петрухин А.С., Воронкова К.В., Пылаева О.А. Лакосамид в лечении эпилепсии. Журнал неврологии и психиатрии им. С.С. Корсакова 2012;112(6 выпуск 2): 65–71. [Petrukhin A.S., Voronkova K.V., Pylaeva O.A. Lacosamide for treatment of epilepsy. S.S. Korsakov Journal of Neurology and Psychiatrics 2012;112(6 issue 2):65–71].</mixed-citation><mixed-citation xml:lang="ru">Петрухин А.С., Воронкова К.В., Пылаева О.А. Лакосамид в лечении эпилепсии. Журнал неврологии и психиатрии им. С.С. Корсакова 2012;112(6 выпуск 2): 65–71. [Petrukhin A.S., Voronkova K.V., Pylaeva O.A. Lacosamide for treatment of epilepsy. S.S. Korsakov Journal of Neurology and Psychiatrics 2012;112(6 issue 2):65–71].</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">9. Becerra J.L., Ojeda J., Corredera E., Ruiz Gimenez J. Review of therapeutic options for adjuvant treatment of focal seizures in epilepsy: focus on lacosamide. CNS Drugs 2011;25 Suppl 1:3–16.</mixed-citation><mixed-citation xml:lang="ru">Becerra J.L., Ojeda J., Corredera E., Ruiz Gimenez J. Review of therapeutic options for adjuvant treatment of focal seizures in epilepsy: focus on lacosamide. CNS Drugs 2011;25 Suppl 1:3–16.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">10. Benhaddi H., Gunn A., Ferro B. Medicoeconomic evaluation of lacosamide adjunctive therapy in the treatment of patients with refractory epilepsy in Scotland and Spain.13th Annual European Congress: health technology assessment, 6–9 November 2010, Prague. 11. Ben-Menachem E. Lacosamide: an nvestigational drug for adjunctive treatment of partial-onset seizures. Drugs Today (Barc) 2008;44(1):35–40.</mixed-citation><mixed-citation xml:lang="ru">Benhaddi H., Gunn A., Ferro B. Medicoeconomic evaluation of lacosamide adjunctive therapy in the treatment of patients with refractory epilepsy in Scotland and Spain.13th Annual European Congress: health technology assessment, 6–9 November 2010, Prague. 11. Ben-Menachem E. Lacosamide: an nvestigational drug for adjunctive treatment of partial-onset seizures. Drugs Today (Barc) 2008;44(1):35–40.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Ben-Menachem E. The adjuvant treatment of partial seizures in epilepsy: focus on lacosamide. Foreword. CNS Drugs 2011; 25 Suppl 1:1–2.</mixed-citation><mixed-citation xml:lang="ru">Ben-Menachem E. The adjuvant treatment of partial seizures in epilepsy: focus on lacosamide. Foreword. CNS Drugs 2011; 25 Suppl 1:1–2.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Ben-Menachem E., Biton V., Jatuzis D. et al. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia 2007;48(7):1308–17.</mixed-citation><mixed-citation xml:lang="ru">Ben-Menachem E., Biton V., Jatuzis D. et al. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia 2007;48(7):1308–17.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Biton V. Lacosamide for the treatment of partial-onset seizures. Expert Rev Neurother 2012;12(6):645–55.</mixed-citation><mixed-citation xml:lang="ru">Biton V. Lacosamide for the treatment of partial-onset seizures. Expert Rev Neurother 2012;12(6):645–55.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Biton V., Rosenfeld W.E., Whitesides J. et al. Intravenous lacosamide as replacement for oral lacosamide in patients with partialonset seizures. Epilepsia 2008;49(3):418–24.</mixed-citation><mixed-citation xml:lang="ru">Biton V., Rosenfeld W.E., Whitesides J. et al. Intravenous lacosamide as replacement for oral lacosamide in patients with partialonset seizures. Epilepsia 2008;49(3):418–24.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Bolin K., Berggren F., Forsgren L. Lacosamide as treatment of epileptic seizures – cost utility results for Sweden. Acta Neurol Scand 2010;121(6):406–12.</mixed-citation><mixed-citation xml:lang="ru">Bolin K., Berggren F., Forsgren L. Lacosamide as treatment of epileptic seizures – cost utility results for Sweden. Acta Neurol Scand 2010;121(6):406–12.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Borghs S., de la Loge C., Cramer J.A. Defining minimally important change in QOLIE-31 scores: estimates from three placebo-controlled lacosamide trials in patients with partial-onset seizures. Epilepsy Behav 2012;23(3):230–4.</mixed-citation><mixed-citation xml:lang="ru">Borghs S., de la Loge C., Cramer J.A. Defining minimally important change in QOLIE-31 scores: estimates from three placebo-controlled lacosamide trials in patients with partial-onset seizures. Epilepsy Behav 2012;23(3):230–4.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Cawello W., Boekens H., Bonn R. Absorption, disposition, metabolic fate and elimination of the anti-epileptic drug lacosamide in humans: mass balance following intravenous and oral administration. Eur J Drug Metab Pharmacokinet 2012;37(4):241–8.</mixed-citation><mixed-citation xml:lang="ru">Cawello W., Boekens H., Bonn R. Absorption, disposition, metabolic fate and elimination of the anti-epileptic drug lacosamide in humans: mass balance following intravenous and oral administration. Eur J Drug Metab Pharmacokinet 2012;37(4):241–8.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Chatzistefanidis D., Karvouni E., Kyritsis A.P., Markoula S. First case of lacosamide-induced psychosis. Clin Neuropharmacol 2013;36(1):27–8.</mixed-citation><mixed-citation xml:lang="ru">Chatzistefanidis D., Karvouni E., Kyritsis A.P., Markoula S. First case of lacosamide-induced psychosis. Clin Neuropharmacol 2013;36(1):27–8.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Chinnasami S., Rathore C., Duncan J.S. Sinus node dysfunction: An adverse effect of lacosamide. Epilepsia 2013;54(6):е90–3. doi: 10.1111/epi.12108.</mixed-citation><mixed-citation xml:lang="ru">Chinnasami S., Rathore C., Duncan J.S. Sinus node dysfunction: An adverse effect of lacosamide. Epilepsia 2013;54(6):е90–3. doi: 10.1111/epi.12108.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Chung S., Ben-Menachem E., Sperling M.R. et аl. Examining the clinical utility of lacosamide: pooled analyses of three phase II/III clinical trials. CNS Drugs 2010;24(12):1041–54.</mixed-citation><mixed-citation xml:lang="ru">Chung S., Ben-Menachem E., Sperling M.R. et аl. Examining the clinical utility of lacosamide: pooled analyses of three phase II/III clinical trials. CNS Drugs 2010;24(12):1041–54.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Chung S., Sperling M.R., Biton V. et al.; SP754 Study Group. Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial. Epilepsia 2010;51(6):958–67.</mixed-citation><mixed-citation xml:lang="ru">Chung S., Sperling M.R., Biton V. et al.; SP754 Study Group. Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial. Epilepsia 2010;51(6):958–67.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Elger C.E., Schmidt D. Modern management of epilepsy: а practical approach. Epilepsy Behav 2008;12(4):501–39.</mixed-citation><mixed-citation xml:lang="ru">Elger C.E., Schmidt D. Modern management of epilepsy: а practical approach. Epilepsy Behav 2008;12(4):501–39.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Errington A.C., Coyne L., Stohr T. et al. Seeking a mechanism of action for the novel anticonvulsant lacosamide. Neuropharmacology 2006;50(8):1016–29.</mixed-citation><mixed-citation xml:lang="ru">Errington A.C., Coyne L., Stohr T. et al. Seeking a mechanism of action for the novel anticonvulsant lacosamide. Neuropharmacology 2006;50(8):1016–29.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Errington A.C., Stöhr T., Heers C., Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008;73(1): 157–69.</mixed-citation><mixed-citation xml:lang="ru">Errington A.C., Stöhr T., Heers C., Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008;73(1): 157–69.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Flores L., Kemp S., Colbeck K. et al. Clinical experience with oral lacosamide as adjunctive therapy in adult patients with uncontrolled epilepsy: a multicentre study in epilepsy clinics in the United Kingdom (UK). Seizure 2012;21(7):512–7.</mixed-citation><mixed-citation xml:lang="ru">Flores L., Kemp S., Colbeck K. et al. Clinical experience with oral lacosamide as adjunctive therapy in adult patients with uncontrolled epilepsy: a multicentre study in epilepsy clinics in the United Kingdom (UK). Seizure 2012;21(7):512–7.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Garcia-Morales I., Delgado R.T., Falip M. et al. Early clinical experience with lacosamide as adjunctive therapy in patients with refractory focal epilepsy and nocturnal seizures. Seizure 2011;20(10):801–4.</mixed-citation><mixed-citation xml:lang="ru">Garcia-Morales I., Delgado R.T., Falip M. et al. Early clinical experience with lacosamide as adjunctive therapy in patients with refractory focal epilepsy and nocturnal seizures. Seizure 2011;20(10):801–4.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Gil-Nagel A., Marin H. Lacosamide: a new generation in the treatment of epilepsy. Rev Neurol 2011;52(3):159–62.</mixed-citation><mixed-citation xml:lang="ru">Gil-Nagel A., Marin H. Lacosamide: a new generation in the treatment of epilepsy. Rev Neurol 2011;52(3):159–62.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Glauser T., Ben-Menachem E., Bourgeois B. et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006;47(7):1094–120.</mixed-citation><mixed-citation xml:lang="ru">Glauser T., Ben-Menachem E., Bourgeois B. et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006;47(7):1094–120.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Guilhoto L.M., Loddenkemper T., Gooty V.D. et al. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol 2011;44(6):414–9.</mixed-citation><mixed-citation xml:lang="ru">Guilhoto L.M., Loddenkemper T., Gooty V.D. et al. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol 2011;44(6):414–9.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Halasz P., Kalviainen R., Mazurkiewicz-Beldzinska M. et al.; SP755 Study Group. Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial. Epilepsia 2009;50(3):443–53.</mixed-citation><mixed-citation xml:lang="ru">Halasz P., Kalviainen R., Mazurkiewicz-Beldzinska M. et al.; SP755 Study Group. Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial. Epilepsia 2009;50(3):443–53.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Hao X.T., Wong I.S., Kwan P. Interrater reliability of the international consensus definition of drug-resistant epilepsy: a pilot study. Epilepsy Behav 2011;22(2):388–90.</mixed-citation><mixed-citation xml:lang="ru">Hao X.T., Wong I.S., Kwan P. Interrater reliability of the international consensus definition of drug-resistant epilepsy: a pilot study. Epilepsy Behav 2011;22(2):388–90.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">33. Harden C.L., Cohn A., Lowe M., Serrano E. Initial post marketing experience with lacosamide in adult patients with epilepsy. Epilepsy Res 2012;98(2–3):260–3.</mixed-citation><mixed-citation xml:lang="ru">Harden C.L., Cohn A., Lowe M., Serrano E. Initial post marketing experience with lacosamide in adult patients with epilepsy. Epilepsy Res 2012;98(2–3):260–3.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">34. Harris J.A., Murphy J.A. Lacosamide: an adjunctive agent for partial-onset seizures and potential therapy for neuropathic pain. Ann Pharmacother 2009;43(11):1809–17.</mixed-citation><mixed-citation xml:lang="ru">Harris J.A., Murphy J.A. Lacosamide: an adjunctive agent for partial-onset seizures and potential therapy for neuropathic pain. Ann Pharmacother 2009;43(11):1809–17.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">35. Harris J.A., Murphy J.A. Lacosamide and еpilepsy. CNS Neurosci Ther 2011;17(6):678–82.</mixed-citation><mixed-citation xml:lang="ru">Harris J.A., Murphy J.A. Lacosamide and еpilepsy. CNS Neurosci Ther 2011;17(6):678–82.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">36. Helmstaedter C., Witt J.A. The longer-term cognitive effects of adjunctive antiepileptic treatment with lacosamide in comparison with lamotrigine and topiramate in a naturalistic outpatient setting. Epilepsy Behav 2013;26(2):182–7.</mixed-citation><mixed-citation xml:lang="ru">Helmstaedter C., Witt J.A. The longer-term cognitive effects of adjunctive antiepileptic treatment with lacosamide in comparison with lamotrigine and topiramate in a naturalistic outpatient setting. Epilepsy Behav 2013;26(2):182–7.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">37. Höfler J., Trinka E. Lacosamide as a new treatment option in status epilepticus. Epilepsia 2013;54(3):393–404.</mixed-citation><mixed-citation xml:lang="ru">Höfler J., Trinka E. Lacosamide as a new treatment option in status epilepticus. Epilepsia 2013;54(3):393–404.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">38. Husain A., Chung S., Faught E. et al. Long-term safety and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: results from a Phase III open-label extension trial. Epilepsia 2012;53(3):521–8.</mixed-citation><mixed-citation xml:lang="ru">Husain A., Chung S., Faught E. et al. Long-term safety and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: results from a Phase III open-label extension trial. Epilepsia 2012;53(3):521–8.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">39. Johannessen S.I., Ben-Menachem E. Management of focal-onset seizures. an update on drug treatment. Drugs 2006;66(13): 1701–25.</mixed-citation><mixed-citation xml:lang="ru">Johannessen S.I., Ben-Menachem E. Management of focal-onset seizures. an update on drug treatment. Drugs 2006;66(13): 1701–25.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">40. Jones G.L., Popli G.S., Silvia M.T. Lacosamide-induced valproic acid toxicity. Pediatr Neurol 2013;48(4):308–10.</mixed-citation><mixed-citation xml:lang="ru">Jones G.L., Popli G.S., Silvia M.T. Lacosamide-induced valproic acid toxicity. Pediatr Neurol 2013;48(4):308–10.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">41. Kamel J.T., Degruyter M.A., D'Souza W.J., Cook M.J. Clinical experience with using lacosamide for the treatment of epilepsy in a tertiary centre. Acta Neurol Scand 2013;127(3):149–53.</mixed-citation><mixed-citation xml:lang="ru">Kamel J.T., Degruyter M.A., D'Souza W.J., Cook M.J. Clinical experience with using lacosamide for the treatment of epilepsy in a tertiary centre. Acta Neurol Scand 2013;127(3):149–53.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">42. Kelemen A., Halasz P. Lacosamide for the prevention of partial onset seizures in epileptic adults. Neuropsychiatr Dis Treat 2010;6: 465–71.</mixed-citation><mixed-citation xml:lang="ru">Kelemen A., Halasz P. Lacosamide for the prevention of partial onset seizures in epileptic adults. Neuropsychiatr Dis Treat 2010;6: 465–71.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">43. Kellinghaus C. Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety. Ther Clin Risk Manag 2009;5:757–66.</mixed-citation><mixed-citation xml:lang="ru">Kellinghaus C. Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety. Ther Clin Risk Manag 2009;5:757–66.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">44. Kellinghaus C. Reversible suicidal ideation fter exposure to lacosamide. Seizure 2013;22(4):318–9.</mixed-citation><mixed-citation xml:lang="ru">Kellinghaus C. Reversible suicidal ideation fter exposure to lacosamide. Seizure 2013;22(4):318–9.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">45. Kobow K., El-Osta A., Blümcke I. The methylation hypothesis of pharmacoresistance in epilepsy. Epilepsia 2013;54 Suppl 2:41–7.</mixed-citation><mixed-citation xml:lang="ru">Kobow K., El-Osta A., Blümcke I. The methylation hypothesis of pharmacoresistance in epilepsy. Epilepsia 2013;54 Suppl 2:41–7.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">46. Krause L.U., Brodowski K.O., Kellinghaus C. Atrioventricular block following lacosamide intoxication. Epilepsy Behav 2011;20(4):725–7.</mixed-citation><mixed-citation xml:lang="ru">Krause L.U., Brodowski K.O., Kellinghaus C. Atrioventricular block following lacosamide intoxication. Epilepsy Behav 2011;20(4):725–7.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">47. Krauss G., Ben-Menachem E., Mameniskiene R. et al.; SP757 Study Group. Intravenous lacosamide as short-term replacement for oral lacosamide in partialonset seizures. Epilepsia 2010;51(6):951–7.</mixed-citation><mixed-citation xml:lang="ru">Krauss G., Ben-Menachem E., Mameniskiene R. et al.; SP757 Study Group. Intravenous lacosamide as short-term replacement for oral lacosamide in partialonset seizures. Epilepsia 2010;51(6):951–7.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">48. Krauss G.L., Edwards H.B., Lin B. Lacosamide for the treatment of epilepsy. Ann Med 2012;44(7):674–9.</mixed-citation><mixed-citation xml:lang="ru">Krauss G.L., Edwards H.B., Lin B. Lacosamide for the treatment of epilepsy. Ann Med 2012;44(7):674–9.</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">49. Kwan P., Brodie M.J. Early identification of refractory epilepsy. N Engl J Med 2000;342(5):314–9.</mixed-citation><mixed-citation xml:lang="ru">Kwan P., Brodie M.J. Early identification of refractory epilepsy. N Engl J Med 2000;342(5):314–9.</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">50. Kwan P., Brodie M.J. Epilepsy after the first drug fails: substitution or add-on? Seizure 2000;9(7):464–8.</mixed-citation><mixed-citation xml:lang="ru">Kwan P., Brodie M.J. Epilepsy after the first drug fails: substitution or add-on? Seizure 2000;9(7):464–8.</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><citation-alternatives><mixed-citation xml:lang="en">51. Kwan P., Brodie M.J. Refractory epilepsy: mechanisms and solutions. Expert Rev Neurother 2006;6(3):397–406.</mixed-citation><mixed-citation xml:lang="ru">Kwan P., Brodie M.J. Refractory epilepsy: mechanisms and solutions. Expert Rev Neurother 2006;6(3):397–406.</mixed-citation></citation-alternatives></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">52. Miro J., Toledo M., Santamarina E. et al. Efficacy of intravenous lacosamide as an addon treatment in refractory status epilepticus: a multicentric prospective study. Seizure 2013;22(1):77–9.</mixed-citation><mixed-citation xml:lang="ru">Miro J., Toledo M., Santamarina E. et al. Efficacy of intravenous lacosamide as an addon treatment in refractory status epilepticus: a multicentric prospective study. Seizure 2013;22(1):77–9.</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">53. Niespodziany I., Leclere N., Vandenplas C. et al. Comparative study of lacosamide and classical sodium channel blocking antiepileptic drugs on sodium channel slow inactivation. J Neurosci Res 2013;91(3):436–43.</mixed-citation><mixed-citation xml:lang="ru">Niespodziany I., Leclere N., Vandenplas C. et al. Comparative study of lacosamide and classical sodium channel blocking antiepileptic drugs on sodium channel slow inactivation. J Neurosci Res 2013;91(3):436–43.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">54. Nizam A., Mylavarapu K., Thomas D. et al. Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy. Epilepsia 2011;52(10):e153–5.</mixed-citation><mixed-citation xml:lang="ru">Nizam A., Mylavarapu K., Thomas D. et al. Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy. Epilepsia 2011;52(10):e153–5.</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">55. O'Brien T.J., Mosewich R.K., Britton J.W. et al. History and seizure semiology in distinguishing frontal lobe seizures and temporal lobe seizures. Epilepsy Res 2008;82(2–3):177–82.</mixed-citation><mixed-citation xml:lang="ru">O'Brien T.J., Mosewich R.K., Britton J.W. et al. History and seizure semiology in distinguishing frontal lobe seizures and temporal lobe seizures. Epilepsy Res 2008;82(2–3):177–82.</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">56. Panayotopoulos С.P. Principles of Therapy in the Epilepsies. In: A Panayotopoulos. Clinical Guide to Epileptic Syndromes and their Treatment. Springer, 2007. Pр. 155–84.</mixed-citation><mixed-citation xml:lang="ru">Panayotopoulos С.P. Principles of Therapy in the Epilepsies. In: A Panayotopoulos. Clinical Guide to Epileptic Syndromes and their Treatment. Springer, 2007. Pр. 155–84.</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><citation-alternatives><mixed-citation xml:lang="en">57. Patsalos P.N., Berry D.J. Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate. Expert Opin Pharmacother 2012;13(5):699–715.</mixed-citation><mixed-citation xml:lang="ru">Patsalos P.N., Berry D.J. Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate. Expert Opin Pharmacother 2012;13(5):699–715.</mixed-citation></citation-alternatives></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">58. Potschka H. Animal and human data: where are our concepts for drug-resistant epilepsy going? Epilepsia 2013;54 Suppl 2: 29–32.</mixed-citation><mixed-citation xml:lang="ru">Potschka H. Animal and human data: where are our concepts for drug-resistant epilepsy going? Epilepsia 2013;54 Suppl 2: 29–32.</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">59. Rosenow F., Knake S. Recent and future advances in the treatment of status epilepticus.Ther Adv Neurol Disord 2008;1(1):33–42.</mixed-citation><mixed-citation xml:lang="ru">Rosenow F., Knake S. Recent and future advances in the treatment of status epilepticus.Ther Adv Neurol Disord 2008;1(1):33–42.</mixed-citation></citation-alternatives></ref><ref id="B60"><label>60.</label><citation-alternatives><mixed-citation xml:lang="en">60. Sierra-Marcos A., Bermejo P.E., Manso Calderon R. et al. Lacosamide for epileptic seizures in patients with co-morbidities and unusual presentations of epilepsy. CNS Drugs 2011;25 Suppl 1:17–26.</mixed-citation><mixed-citation xml:lang="ru">Sierra-Marcos A., Bermejo P.E., Manso Calderon R. et al. Lacosamide for epileptic seizures in patients with co-morbidities and unusual presentations of epilepsy. CNS Drugs 2011;25 Suppl 1:17–26.</mixed-citation></citation-alternatives></ref><ref id="B61"><label>61.</label><citation-alternatives><mixed-citation xml:lang="en">61. Simoens S. Budget impact analysis of adjunctive therapy with lacosamide for partial-onset epileptic seizures in Belgium. J Med Econ 2011;14(3):299–304.</mixed-citation><mixed-citation xml:lang="ru">Simoens S. Budget impact analysis of adjunctive therapy with lacosamide for partial-onset epileptic seizures in Belgium. J Med Econ 2011;14(3):299–304.</mixed-citation></citation-alternatives></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">62. Simoens S. Lacosamide as adjunctive therapy for partial-onset epileptic seizures: a review of the clinical and economic literature. Curr Med Res Opin 2011;27(7):1329–38.</mixed-citation><mixed-citation xml:lang="ru">Simoens S. Lacosamide as adjunctive therapy for partial-onset epileptic seizures: a review of the clinical and economic literature. Curr Med Res Opin 2011;27(7):1329–38.</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><citation-alternatives><mixed-citation xml:lang="en">63. Simoens S., De Naeyer L., Dedeken P. Cost effectiveness of lacosamide in the adjunctive treatment of patients with refractory focal epilepsy in Belgium. CNS Drugs 2012;26(4):337–50.</mixed-citation><mixed-citation xml:lang="ru">Simoens S., De Naeyer L., Dedeken P. Cost effectiveness of lacosamide in the adjunctive treatment of patients with refractory focal epilepsy in Belgium. CNS Drugs 2012;26(4):337–50.</mixed-citation></citation-alternatives></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">64. Uebachs M., Albus C., Opitz T. et al. Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+currents. Epilepsia 2012;53(11):1959–67.</mixed-citation><mixed-citation xml:lang="ru">Uebachs M., Albus C., Opitz T. et al. Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+currents. Epilepsia 2012;53(11):1959–67.</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><citation-alternatives><mixed-citation xml:lang="en">65. Verrotti A., Loiacono G., Olivieri C. et al. Lacosamide in patients with pharmacoresistant epilepsy. Expert Opin Pharmacother 2012;13(14):2065–72.</mixed-citation><mixed-citation xml:lang="ru">Verrotti A., Loiacono G., Olivieri C. et al. Lacosamide in patients with pharmacoresistant epilepsy. Expert Opin Pharmacother 2012;13(14):2065–72.</mixed-citation></citation-alternatives></ref><ref id="B66"><label>66.</label><citation-alternatives><mixed-citation xml:lang="en">66. Verrotti A., Loiacono G., Pizzolorusso A. et al. Lacosamide in pediatric and adult patients: comparison of efficacy and safety. Seizure 2013;22(3): 210–6.</mixed-citation><mixed-citation xml:lang="ru">Verrotti A., Loiacono G., Pizzolorusso A. et al. Lacosamide in pediatric and adult patients: comparison of efficacy and safety. Seizure 2013;22(3): 210–6.</mixed-citation></citation-alternatives></ref><ref id="B67"><label>67.</label><citation-alternatives><mixed-citation xml:lang="en">67. Villanueva V., Lopez-Gomariz E., Lopez-Trigo J. et al. Rational polytherapy with lacosamide in clinical practice: results of a Spanish cohort analysis RELACOVA. Epilepsy Behav 2012;23(3):298–304.</mixed-citation><mixed-citation xml:lang="ru">Villanueva V., Lopez-Gomariz E., Lopez-Trigo J. et al. Rational polytherapy with lacosamide in clinical practice: results of a Spanish cohort analysis RELACOVA. Epilepsy Behav 2012;23(3):298–304.</mixed-citation></citation-alternatives></ref><ref id="B68"><label>68.</label><citation-alternatives><mixed-citation xml:lang="en">68. Vishwanath V.A., Miller L.M. 3rd. What is the right dose of lacosamide in pediatric patients with intractable epilepsy? Epilepsy Behav 2012;23(3):396–7.</mixed-citation><mixed-citation xml:lang="ru">Vishwanath V.A., Miller L.M. 3rd. What is the right dose of lacosamide in pediatric patients with intractable epilepsy? Epilepsy Behav 2012;23(3):396–7.</mixed-citation></citation-alternatives></ref><ref id="B69"><label>69.</label><citation-alternatives><mixed-citation xml:lang="en">69. Wang B., Dawson H., Wang H. et al. Lacosamide improves outcome in a murine model of traumatic brain injury. Neurocrit Care 2013;19(1):125–34.</mixed-citation><mixed-citation xml:lang="ru">Wang B., Dawson H., Wang H. et al. Lacosamide improves outcome in a murine model of traumatic brain injury. Neurocrit Care 2013;19(1):125–34.</mixed-citation></citation-alternatives></ref><ref id="B70"><label>70.</label><citation-alternatives><mixed-citation xml:lang="en">70. Wilson S.M., Xiong W., Wang Y. et al. Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization. Neuroscience 2012;210:451–66.</mixed-citation><mixed-citation xml:lang="ru">Wilson S.M., Xiong W., Wang Y. et al. Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization. Neuroscience 2012;210:451–66.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
