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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Child Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Child Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Русский журнал детской неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-8803</issn><issn publication-format="electronic">2412-9178</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">386</article-id><article-id pub-id-type="doi">10.17650/2073-8803-2021-16-4-49-58</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Possibilities of therapy for neuromyelitis optica spectrum disorders</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности терапии при заболеваниях спектра оптиконевромиелита</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6004-9111</contrib-id><name-alternatives><name xml:lang="en"><surname>Novikova</surname><given-names>E. S.</given-names></name><name xml:lang="ru"><surname>Новикова</surname><given-names>Е. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Еkaterina Sergeevna Novikova</bold></p><p><italic>129110, Moscow, Shchepkina St., 61/2</italic></p></bio><bio xml:lang="ru"><p><bold>Екатерина Сергеевна Новикова</bold></p><p><italic>129110 Москва, ул. Щепкина, 61/2</italic></p></bio><email>novikova.ekserg@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">M.F. Vladimirsky Moscow Regional Research Clinical Institute</institution></aff><aff><institution xml:lang="ru">ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2021</year></pub-date><volume>16</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>49</fpage><lpage>58</lpage><history><date date-type="received" iso-8601-date="2022-01-31"><day>31</day><month>01</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-01-31"><day>31</day><month>01</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, АБВ-пресс</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://rjdn.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://rjdn.abvpress.ru/jour/article/view/386">https://rjdn.abvpress.ru/jour/article/view/386</self-uri><abstract xml:lang="en"><p>Neuromyelitis optica spectrum disorders are rare chronic autoimmune inflammatory demyelinating diseases of the central nervous system. Considering that the increase in neurological deficit in neuromyelitis optica spectrum disorders is mainly due to repeated exacerbations, the goals of pharmacotherapy are represented by the relief of relapses and the prevention of their development. Information about indications for therapy and side effects is necessary to identify the benefits and risks for patients with neuromyelitis optica spectrum disorders in each individual case.</p></abstract><trans-abstract xml:lang="ru"><p>Заболевания спектра оптиконевромиелита – редкие хронические аутоиммунные воспалительные демиелинизирующие заболевания центральной нервной системы. Учитывая, что нарастание неврологического дефицита при заболеваниях спектра оптиконевромиелита обусловлено преимущественно повторяющимися обострениями, задачи фармакотерапии включают купирование рецидивов и предупреждение их развития. Информация о показаниях к назначению терапии и потенциальных побочных эффектах препаратов необходима для четкой оценки потенциальных преимуществ и рисков для пациентов с заболеваниями спектра оптиконевромиелита в каждом индивидуальном случае.</p></trans-abstract><kwd-group xml:lang="en"><kwd>neuromyelitis optica spectrum disorders</kwd><kwd>antibodies to myelinoligodendrocyte glycoprotein</kwd><kwd>antibodies to aquaporin 4</kwd><kwd>interleukin 6</kwd><kwd>anti-B-cell therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>заболевания спектра оптиконевромиелита</kwd><kwd>антитела к миелинолигодендроцитарному гликопротеину</kwd><kwd>антитела к аквапорину 4</kwd><kwd>интерлейкин 6</kwd><kwd>анти-В-клеточная терапия</kwd></kwd-group><funding-group><funding-statement xml:lang="en">This article was prepared with the support of Roche.</funding-statement><funding-statement xml:lang="ru">Статья подготовлена при поддержке компании Roche.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Boyko A.N., Smirnova N.F., Shchukin I.A. et al. 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