Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press33410.17650/2073-8803-2020-15-2-55-59CLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯDifficulties of differential diagnostics of Guillain–Barré syndrome in children. The discussion of two clinical casesТрудности дифференциальной диагностики синдрома Гийена–Барре у детей. Разбор двух клинических случаевhttps://orcid.org/0000-0003-2988-5706KotovA. S.КотовА. С.
Russian Federation

61/2 Shchepkina St., Moscow 129110

Алексей Сергеевич Котов

129110 Москва, ул. Щепкина, 61/2

alex-013@yandex.ruhttps://orcid.org/0000-0002-8145-7023MukhinaE. V.МухинаЕ. В.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0000-0003-1169-5437ShatalinA. V.ШаталинА. В.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0000-0002-4099-8202PanteleevaM. V.ПантелееваМ. В.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0000-0001-6436-0249BunakM. S.БунакМ. С.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

M.F. Vladimirsky Moscow Regional Research Clinical InstituteГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»1504202015255592809202028092020Copyright ©; 2020, ABV-PressCopyright ©; 2020, АБВ-пресс2020ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/334

Guillain–Barré syndrome – an acute demyelinating autoimmune disease characterized by lesions of the peripheral nervous system and consequently peripheral paralysis, paresthesias and/or pain. Guillain–Barré syndrome is a predominant cause of acute flaccid paralysis, which may occur at any age. We present two clinical cases of flaccid paralysis with patients at the age of 7 and 5 years requiring verification of the diagnosis.

Синдром Гийена–Барре – острое демиелинизирующее аутоиммунное заболевание, характеризующееся поражением периферической нервной системы и, как следствие, периферическим параличом, парестезией и/или болевым синдромом. Синдром Гийена– Барре является основной причиной острого периферического паралича, который может возникнуть в любом возрасте. Представлены 2 клинических случая периферического паралича у пациентов в возрасте 5 и 7 лет, требующие верификации диагноза.

Guillain–Barré syndromeperipheral paralysisсиндром Гийена–Баррепериферический паралич1. Пирадов М.А., Супонева Н.А. Синдром Гийена–Барре: диагностика и лечение. М.: МЕДпресс-информ, 2011. 208 с. [Piradov M.A., Suponeva N.A. Guillain–Barré syndrome: diagnosis and treatment. Moscow: MEDpress-inform, 2011. 208 p. (In Russ.)].Пирадов М.А., Супонева Н.А. Синдром Гийена–Барре: диагностика и лечение. М.: МЕДпресс-информ, 2011. 208 с. [Piradov M.A., Suponeva N.A. Guillain–Barré syndrome: diagnosis and treatment. Moscow: MEDpress-inform, 2011. 208 p. (In Russ.)].2. Dimario F.J.Jr., Edwards C. Autonomic dysfunction in childhood Guillain–Barré syndrome. J Child Neurol 2012;27:581–6. DOI: 10.1177/0883073811420872.Dimario F.J.Jr., Edwards C. Autonomic dysfunction in childhood Guillain–Barré syndrome. J Child Neurol 2012;27:581–6. DOI: 10.1177/0883073811420872.3. Hu M.H., Chen C.M., Lin K.L. et al. Risk factors of respiratory failure in children with Guillain–Barré syndrome. Pediatr Neonatol 2012;53:295–9. DOI: 10.1016/j.pedneo.2012.07.003.Hu M.H., Chen C.M., Lin K.L. et al. Risk factors of respiratory failure in children with Guillain–Barré syndrome. Pediatr Neonatol 2012;53:295–9. DOI: 10.1016/j.pedneo.2012.07.003.4. Hughes R.A., Cornblath D.R. Guillain–Barré syndrome. Lancet 2005;366(9497):1653–66. DOI: 10.1016/S0140-6736(05)67665-9.Hughes R.A., Cornblath D.R. Guillain–Barré syndrome. Lancet 2005;366(9497):1653–66. DOI: 10.1016/S0140-6736(05)67665-9.5. Lee J.H., Sung I.Y., Rew I.S. Clinical presentation and prognosis of childhood Guillain–Barré syndrome. J Paediatr Child Health 2008;44:449–54. DOI: 10.1111/j.1440-1754.2008.01325.x.Lee J.H., Sung I.Y., Rew I.S. Clinical presentation and prognosis of childhood Guillain–Barré syndrome. J Paediatr Child Health 2008;44:449–54. DOI: 10.1111/j.1440-1754.2008.01325.x.6. Rantala H., Uhari M., Cherry J.D., Shields W.D. Risk factors of respiratory failure in children with Guillain–Barré syndrome. Pediatr Neurol 1995;13:289–92.Rantala H., Uhari M., Cherry J.D., Shields W.D. Risk factors of respiratory failure in children with Guillain–Barré syndrome. Pediatr Neurol 1995;13:289–92.7. Ryan M.M. Guillain–Barré syndrome in childhood. J Paediatr Child Health 2005;41:237–41.Ryan M.M. Guillain–Barré syndrome in childhood. J Paediatr Child Health 2005;41:237–41.8. Samadi M., Kazemi B., Golzari Oskoui S., Barzegar M. Assessment of autonomic dysfunction in childhood Guillain–Barré syndrome. J Cardiovasc Thorac Res 2013;5:81–5. DOI: 10.5681/jcvtr.2013.018Samadi M., Kazemi B., Golzari Oskoui S., Barzegar M. Assessment of autonomic dysfunction in childhood Guillain–Barré syndrome. J Cardiovasc Thorac Res 2013;5:81–5. DOI: 10.5681/jcvtr.2013.0189. Sarada C., Tharakan J.K., Nair M. Guillain–Barré syndrome. A prospective clinical study in 25 children and comparison with adults. Ann Trop Paediatr 1994;14:281–6.Sarada C., Tharakan J.K., Nair M. Guillain–Barré syndrome. A prospective clinical study in 25 children and comparison with adults. Ann Trop Paediatr 1994;14:281–6.10. Van den Berg B., Walgaard C., Drenthen J. et al. Guillain–Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol 2014;10:469–82. DOI: 10.1038/nrneurol.2014.121.Van den Berg B., Walgaard C., Drenthen J. et al. Guillain–Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol 2014;10:469–82. DOI: 10.1038/nrneurol.2014.121.11. Wu X., Shen D., Li T. et al. Distinct clinical characteristics of pediatric Guillain–Barré syndrome: a comparative study between children and adults in Northeast China. PLoS One 2016;11(3):e0151611. DOI:10.1371/journal.pone.0151611.Wu X., Shen D., Li T. et al. Distinct clinical characteristics of pediatric Guillain–Barré syndrome: a comparative study between children and adults in Northeast China. PLoS One 2016;11(3):e0151611. DOI:10.1371/journal.pone.0151611.