Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press33310.17650/2073-8803-2020-15-2-42-54REVIEWS AND LECTURESОБЗОРЫ И ЛЕКЦИИOverview of anticonvulsant therapy in full-term and premature neonatesОбзор противосудорожной терапии у доношенных и недоношенных новорожденныхhttps://orcid.org/0000-0002-0331-4916IvzhitsM. A.ИвжицМ. А.
Russian Federation

10 Pistsovaya St., Moscow 127015

6 Miklukho-Maklaya St., Moscow 117198

Марина Александровна Ивжиц

127015 Москва, ул. Писцовая, 10 

117198 Москва, ул. Миклухо-Маклая, 6 

ivzhits@yandex.ruZyryanovS. K.ЗыряновС. К.
Russian Federation

10 Pistsovaya St., Moscow 127015

6 Miklukho-Maklaya St., Moscow 117198

127015 Москва, ул. Писцовая, 10 

117198 Москва, ул. Миклухо-Маклая, 6 

RodomanG. V.РодоманГ. В.
Russian Federation

10 Pistsovaya St., Moscow 127015

1 Ostrovityanova St., Moscow 117997

127015 Москва, ул. Писцовая, 10

117997 Москва, ул. Островитянова, 1 

BondarevaI. B.БондареваИ. Б.
Russian Federation

6 Miklukho-Maklaya St., Moscow 117198

117198 Москва, ул. Миклухо-Маклая, 6

DumovaS. V.ДумоваС. В.
Russian Federation

1 Ostrovityanova St., Moscow 117997

39 4 th Vyatskiy Per., Moscow 127287 

117997 Москва, ул. Островитянова, 1

127287 Москва, 4-й Вятский пер., 39 

BabakO. A.БабакО. А.
Russian Federation

39 4 th Vyatskiy Per., Moscow 127287

127287 Москва, 4-й Вятский пер., 39

ChenkurovM. S.ЧенкуровМ. С.
Russian Federation

6 Miklukho-Maklaya St., Moscow 117198

117198 Москва, ул. Миклухо-Маклая, 6

PutsmanG. A.ПуцманГ. А.
Russian Federation

6 Miklukho-Maklaya St., Moscow 117198

117198 Москва, ул. Миклухо-Маклая, 6

City Clinical Hospital No. 24, Moscow Healthcare DepartmentГБУЗ «Городская клиническая больница № 24 Департамента здравоохранения г. Москвы»Peoples’ Friendship University of RussiaФГАОУ ВО «Российский университет дружбы народов»N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииPerinatal Center, City Clinical Hospital No. 24, Moscow Healthcare DepartmentПеринатальный центр ГБУЗ «Городская клиническая больница № 24 Департамента здравоохранения г. Москвы»1504202015242542809202028092020Copyright ©; 2020, ABV-PressCopyright ©; 2020, АБВ-пресс2020ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/333

Convulsions in full-term and especially in premature newborns are observable pathologies. Selection of anticonvulsant therapy is very difficult: newborns have particular pharmacokinetics of drugs, insufficient data on doses and therapeutic concentrations of anticonvulsants in the blood (premature infants mainly). This article is an overview, with an emphasis on the features of dosing and pharmacokinetics of anticonvulsants in term and preterm infants.

Судороги у доношенных и особенно у недоношенных новорожденных – часто встречающаяся патология. Подбор противосудорожной терапии у пациентов этой категории представляется очень сложной задачей, так как у новорожденных (особенно у недоношенных) имеются связанные с возрастом особенности фармакокинетики, недостаточно данных о дозах и терапевтических концентрациях антиэпилептических препаратов в крови. Авторы представляют обзор литературы с акцентом на особенности дозирования и фармакокинетические свойства антиэпилептических препаратов у доношенных и недоношенных новорожденных.

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