Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press28510.17650/2073-8803-2019-14-1-40-48REVIEWS AND LECTURESОБЗОРЫ И ЛЕКЦИИControversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regressionДискуссионные вопросы коморбидности аутизма и эпилепсии: субклиническая эпилептиформная активность и аутистический эпилептиформный регрессKuzmichG. V.КузьмичГ. B.
Russian Federation

5 Nagornaya St., Troitsk, Moscow 108840; 21A 5th Donskoy proezd, Moscow 119334

Григорий Викторович Кузьмич 

108840 Москва, Троицк, ул. Нагорная, 5; 119334 Москва, 5-й Донской проезд, 21А

 

kuzmichgv@mail.ruSinelnikovaA. N.СинельниковаА. Н.
Russian Federation

Medical Institute 

6 Miklukho-Maklaya St., Moscow 117198

117198 Москва, ул. Миклухо-Маклая, 6

MukhinK. Yu.МухинК. Ю.
Russian Federation

5 Nagornaya St., Troitsk, Moscow 108840

108840 Москва, Троицк, ул. Нагорная, 5

Svt. Luka’s Institute of Child Neurology and EpilepsyООО «Институт детской неврологии и эпилепсии им. Святителя Луки»Scientific and Practical Center for Mental Health of Children and Adolescents named after G.E. Sukhareva, Moscow City Department of HealthГБУЗ «Научно-практический центр психического здоровья детей и подростков им. Г.Е. Сухаревой» ДЗМPeoples’ Friendship University of RussiaФГАОУ ВО «Российский университет дружбы народов»1501201914140482305201923052019Copyright ©; 2019, ABV-PressCopyright ©; 2019, АБВ-пресс2019ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/285

Early childhood autism, or autism spectrum disorders, is an extremely heterogeneous group of conditions that share similar symptoms of dysontogenesis. The most significant comorbidity in patients with autism is epilepsy, which is still associated with a variety of controversies. The present article covers the most controversial aspects of comorbidity between autism and epilepsy, including the impact of psychopharmacotherapy on the risk of epilepsy, clinical significance of epileptiform activity on the electroencephalogram in patients without epilepsy, and criteria for and prevalence of autistic epileptiform regression syndrome. We found that there is still a lack of reliable evidence for the majority of issues related to the combination of autism and epilepsy. We emphasize the need for further studies. We also provide a detailed description of the history, criteria, prevalence, and clinical examples of autistic epileptiform regression syndrome.

Ранний детский аутизм, или расстройства аутистического спектра, – крайне разнородная группа состояний, объединенных едиными признаками дизонтогенеза. Наиболее значимым коморбидным заболеванием при аутизме является эпилепсия, с которой связано большое количество дискуссионных до настоящего времени вопросов.

Авторы представляют обзор данных литературы по следующим наиболее дискуссионным и спорным вопросам коморбидности аутизма и эпилепсии: влияние проводимой психофармакотерапии на риск развития эпилепсии; клиническое значение эпилептиформной активности на электроэнцефалограмме при отсутствии эпилепсии; критерии и встречаемость синдрома аутистического эпилептиформного регресса. Выявлено, что по большинству анализируемых вопросов о сочетании аутизма и эпилепсии до настоящего времени недостаточно достоверных и доказательных данных. Подчеркивается значимость дальнейших исследований. Дан подробный анализ истории возникновения, критериев, встречаемости, клинических примеров и дискуссионности синдрома аутистического эпилептиформного регресса.

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