Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press28110.17650/2073-8803-2019-14-1-7-13ORIGINAL REPORTSОРИГИНАЛЬНЫЕ СТАТЬИShall we treat patients with benign epileptiform discharges of childhood without epileptic seizures?Нужно ли лечить пациентов с доброкачественными эпилептиформными разрядами детского возраста без эпилептических приступов?ErmolenkoN. A.ЕрмоленкоН. А.
Russian Federation

1 Burdenko St., Voronezh 394068

Наталия Александровна Ермоленко

394068 Воронеж, ул. Бурденко, 1

ermola@bk.ruBakhtinI. S.БахтинИ. С.
Russian Federation

1 Ploshad Pobedy, Krasnodar 350007

350007 Краснодар, площадь Победы, 1

BuchnevaI. A.БучневаИ. А.
Russian Federation

1 Burdenko St., Voronezh 394068

394068 Воронеж, ул. Бурденко, 1

Voronezh Regional Children’s Clinical Hospital No. 1БУЗ ВО «Воронежская областная детская клиническая больница № 1»Children’s Regional Clinical Hospital, Ministry of Health of Krasnodar RegionГБУЗ «Детская краевая клиническая больница» Министерства здравоохранения Краснодарского края150120191417132305201923052019Copyright ©; 2019, ABV-PressCopyright ©; 2019, АБВ-пресс2019ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/281

Benign epileptiform discharges of childhood are age-dependent electroencephalogram patterns associated with idiopathic benign focal epilepsy. Multiple studies have demonstrated that focal epileptiform discharges can be registered in patients without any clinical manifestations of epilepsy. Long-term follow-up of clinically healthy children with benign epileptiform discharges of childhood on electroencephalogram demonstrated that 14 % of them developed epileptic seizures with age and 50 % developed various cognitive and behavioral disorders. The question of whether or not to treat such patients (with benign epileptiform discharges of childhood on electroencephalogram but without epileptic seizure) is still being widely discussed. Individual decision making with the consideration of potential risks and benefits for a patient is preferable in this case. Valproic acid is the drug of first choice in these patients.

Доброкачественные эпилептиформные разряды детского возраста – возрастзависимый паттерн электроэнцефалограммы, ассоциированный с идиопатическими доброкачественными фокальными эпилепсиями. Дальнейшее изучение показало, что локализованные эпилептиформные разряды могут быть зарегистрированы на электроэнцефалограмме у пациентов и без клинической манифестации эпилепсии. Длительное наблюдение за здоровыми носителями доброкачественных эпилептиформных разрядов детского возраста продемонстрировало присоединение эпилептических приступов с возрастом с частотой до 14 % случаев и различные когнитивные и поведенческие нарушения с частотой до 50 %. Широко дискутируется вопрос о необходимости лечения пациентов с доброкачественными эпилептиформными разрядами детского возраста без эпилептических приступов. В каждом случае вопрос должен решаться индивидуально с учетом риска и пользы. Препаратом выбора в лечении данной категории больных является вальпроевая кислота.

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