Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press27710.17650/2073-8803-2018-13-4-40-52REVIEWS AND LECTURESОБЗОРЫ И ЛЕКЦИИComorbidity between epilepsy and autism from the point of view of ontogenesisКоморбидность аутизма и эпилепсии. Взгляд с точки зрения онтогенезаKuzmichG. V.КузьмичГ. В.
Russian Federation

5 Nagornaya St., Troitsk, Moscow 108840; 21A 5th Donskoy proezd, Moscow 119334.

108840 Москва, Троицк, ул. Нагорная, 5; 119334 Москва, 5-й Донской проезд, 21А.

kuzmichgv@mail.ruSinelnikovaA. N.СинельниковаА. Н.
Russian Federation

6 Miklukho-Maklaya St., Moscow 117198.

кафедра нормальной физиологии медицинского института.

117198 Москва, ул. Миклухо-Маклая, 6. 

Svt. Luka’s Institute of Child Neurology and EpilepsyООО «Институт детской неврологии и эпилепсии им. Свт. Луки»Scientific and Practical Center for Mental Health of Children and Adolescents named after G.E. Sukhareva, Moscow City Department of Health.ГБУЗ «Научно-практический центр психического здоровья детей и подростков им. Г.Е. Сухаревой» ДЗМ.Department of Normal Physiology, Medical Institute, Peoples’ Friendship University of Russia.ФГАОУ ВО «Российский университет дружбы народов».1512201813440521804201918042019Copyright ©; 2018, ABV-PressCopyright ©; 2018, АБВ-пресс2018ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/277

Early childhood autism, or autism spectrum disorders, is an extremely heterogeneous group of conditions that share similar symptoms  of dysontogenesis. Epilepsy is the most significant comorbidity in autism. The present article covers various aspects of comorbidity between epilepsy and autism, described in the literature over the last 50 years. This review aims to analyze the development of epilepsy and autism during ontogenesis and to identify causal relationships between these diseases, considering the information on the two age peaks for epilepsy onset in patients with autism.

Ранний детский аутизм, или расстройства аутистического спектра, с первых описаний синдрома представляет собой крайне разнородную группу состояний, объединенных едиными признаками дизонтогенеза. Наиболее значимым и отягощающим коморбидным заболеванием при аутизме является эпилепсия. В настоящей статье выполнен обзор литературы по различным аспектам коморбидности эпилепсии и аутизма за последние 50 лет. Цель обзора – анализ возникновения эпилепсии и аутизма в процессе онтогенеза, выявление причинно-следственных связей между данными заболеваниями с учетом имеющихся сведений о 2 возрастных пиках дебюта эпилепсии при аутизме.

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