Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press26910.17650/2073-8803-2018-13-2-34-57REVIEWS AND LECTURESОБЗОРЫ И ЛЕКЦИИModern approaches in the treatment of Lennox–gastaut syndrome (a review of literature)Современные подходы в лечении синдрома Леннокса–Гасто (обзор литературы)МukhinК. Yu.МухинК. Ю.
Russian Federation

5 Nagornaya St., Troitsk, Moscow 108840

Константин Юрьевич Мухин 

108840 Москва, Троицк, ул. Нагорная, 5

center@epileptologist.ruPylaevaО. A.ПылаеваО. А.
Russian Federation

5 Nagornaya St., Troitsk, Moscow 108840

108840 Москва, Троицк, ул. Нагорная, 5

Svt. Luka’s Institute of Child Neurology and EpilepsyООО «Институт детской неврологии и эпилепсии им. Святителя Луки»15042018132345730112018Copyright ©; 2018, Мukhin К.Y., Pylaeva О.A.Copyright ©; 2018, Мухин К.Ю., Пылаева О.А.2018Мukhin К.Y., Pylaeva О.A.Мухин К.Ю., Пылаева О.А.https://creativecommons.org/licenses/by/4.0https://rjdn.abvpress.ru/jour/article/view/269

Lennox–Gastaut syndrome (LGS) is a childhood epileptic encephalopathy characterized by frequent polymorphic seizures (including tonic axial seizures), pronounced cognitive impairment, typical changes in the electroencephalogram and drug resistance. Frequency of LGS accounts for approximately 4–10 % of all childhood epilepsy. The difficulties in the diagnosis and treatment of LGS are associated with the presence of various seizures that are frequently resistant to multiple antiepileptic drugs as well as with the disease evolution with age. This review covers the main principles of LGS therapy, analyzes the most common antiepileptic drugs used in LGS, and describes clinical trials evaluating the efficacy and tolerability of antiepileptic drugs in LGS. The article contains a detailed algorithm for the treatment of LGS, based on international guidelines and expert opinions.

Синдром Леннокса – Гасто (СЛГ) – эпилептическая энцефалопатия с дебютом в детском возрасте, проявляющаяся частыми полиморфными приступами, включая тонические аксиальные, выраженными когнитивными нарушениями, характерными изменениями на электроэнцефалограмме и резистентностью к терапии. Частота синдрома составляет 4–10 % всех форм эпилепсии у детей. Сложности диагностики и лечения СЛГ связаны с сочетанием в картине заболевания приступов нескольких типов, их резистентностью к медикаментозной терапии, возможной эволюцией клинической картины синдрома с возрастом. Авторы представляют обзор литературы, посвященный основным принципам лечения СЛГ, анализ антиэпилептических препаратов, наиболее часто применяемых при этом заболевании, подробно рассматривают клинические исследования, в которых были получены доказательства эффективности и переносимости антиэпилептических препаратов при данной форме эпилепсии. Статья содержит подробный алгоритм лечения СЛГ, основанный на международных рекомендациях и мнениях экспертов.

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