Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press23410.17650/2073-8803-2017-12-4-43-49CLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯParoxysmal disorders in children receiving substitution therapy with vitamin B12Пароксизмальные нарушения у детей при заместительной терапии витамином B12BarkhatovM. V.БархатовМ. В.
Russian Federation

1 Partizana Zheleznyaka St., Krasnoyarsk 660022; 2A Akademika Kirenskogo St., Krasnoyarsk 660074.

660022 Красноярск, ул. Партизана Железняка, 1; 660074 Красноярск, ул. Академика Киренского, 2А.

bmv73@mail.ruFalaleevaS. O.ФалалееваС. О.
Russian Federation

2A Akademika Kirenskogo St., Krasnoyarsk 660074;  1 Partizana Zheleznyaka St., Krasnoyarsk 660022.

660074 Красноярск, ул. Академика Киренского, 2А;  660022 Красноярск, ул. Партизана Железняка, 1.

ShishkinaE. V.ШишкинаЕ. В.
Russian Federation

1 Partizana Zheleznyaka St., Krasnoyarsk 660022.

660022 Красноярск, ул. Партизана Железняка, 1.

DenisovaYu. E.ДенисоваЮ. Е.
Russian Federation

2A Akademika Kirenskogo St., Krasnoyarsk 660074.

660074 Красноярск, ул. Академика Киренского, 2А.

BorisovaE. V.БорисоваЕ. В.
Russian Federation

2A Akademika Kirenskogo St., Krasnoyarsk 660074.

660074 Красноярск, ул. Академика Киренского, 2А.

KrasitskiyA. I.КрасицкийА. И.
Russian Federation

2A Akademika Kirenskogo St., Krasnoyarsk 660074.

660074 Красноярск, ул. Академика Киренского, 2А.

MakarevskayaN. Yu.МакаревскаяН. Ю.
Russian Federation

2A Akademika Kirenskogo St., Krasnoyarsk 660074.

660074 Красноярск, ул. Академика Киренского, 2А.

Department of Nervous System Diseases and Medical Rehabilitation, Faculty of General Medicine, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of RussiaКафедра нервных болезней, медицинской реабилитации с курсом ПО лечебного факультета ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава РоссииKrasnoyarsk Regional Clinical Center of Maternity and Childhood.КГБУЗ «Красноярский краевой клинический центр охраны материнства и детства».Krasnoyarsk Regional Clinical Center of Maternity and ChildhoodКГБУЗ «Красноярский краевой клинический центр охраны материнства и детства»Department of Childhood Diseases, Faculty of Pediatrics, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of Russia.Кафедра детских болезней с курсом ПО педиатрического факультета ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России.Department of Nervous System Diseases and Medical Rehabilitation, Faculty of General Medicine, Prof. V.F. Voyno-Yasenetskiy Krasnoyarsk State Medical University, Ministry of Health of Russia.Кафедра нервных болезней, медицинской реабилитации с курсом ПО лечебного факультета ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России.1512201712443491901201819012018Copyright ©; 2017, ABV-PressCopyright ©; 2017, АБВ-пресс2017ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/234

Congenital deficiency of vitamin B12 in children is a frequent metabolic disorder in pediatric practice. The disease has multiple symptoms, including various somatic and nervous manifestations. The main symptom of vitamin B12 deficiency is the regression of psychomotor development with significant trophic impairments and changes in the internal organs. Without substitution therapy with vitamin B12, these children quickly develop irreversible disorders that can lead to death, whereas timely parenteral administration of vitamin B12 can ensure the restoration of the initial development level. We describe a patient aged 1 y. o. 4 months, who was diagnosed with vitamin B12 deficiency anemia and general vitamin B12 deficiency at the age of 8 months; as a result, the child developed various paroxysms that were considered to be epileptic. The patients started to receive vitamin B12 and antiepileptic drugs, which helped to achieve clinical remission with normal psychomotor development.

Врожденный дефицит витамина В12 у детей – нередкое нарушение метаболизма, известное в педиатрической практике. Клинические симптомы этого заболевания многообразны и включают различные проявления как со стороны соматической, так и нервной системы. Основной признак В12-дефицита – регресс психомоторного развития с выраженными трофическими нарушениями и изменениями со стороны внутренних органов. При отсутствии своевременной заместительной терапии витамином В12  у детей быстро наступают необратимые нарушения, которые могут привести к летальному исходу, но своевременное парентеральное введение витамина В12  может восстановить исходный уровень развития. Авторы представляют наблюдение пациента в возрасте 1 год 4 мес, у которого в возрасте 8 мес были диагностированы В12-дефицитная анемия и В12-дефицитное состояние и назначена терапия витамином В12. На этом фоне у ребенка развились различные пароксизмы, которые были расценены как эпилептические, и на фоне лечения антиэпилептическими препаратами была достигнута клиническая ремиссия с нормальным психомоторным развитием ребенка.

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