Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press19310.17650/2073-8803-2017-12-1-47-55REVIEWS AND LECTURESОБЗОРЫ И ЛЕКЦИИTHE IMPACT OF H YPOTHALAMIC-PITUITARY-ADRENAL SYSTEM HORMONES ON EPILEPTOGENESISВлияние гормонов гипоталамо-гипофизарно-надпочечниковой системы на процессы эпилептогенезаShalkevichL. V.ШалькевичЛ. В.
Belarus

3/3 P. Brovka St., Minsk 220013, Republic of Belarus

Республика Беларусь, 220013 Минск, ул. П. Бровки, 3/3

shalkevich_@tut.byKudlachA. I.КудлачА. И.
Belarus

3/3 P. Brovka St., Minsk 220013, Republic of Belarus

Республика Беларусь, 220013 Минск, ул. П. Бровки, 3/3

NazarovaO. P.НазароваО. П.
Belarus

24 F. Skorina St., Minsk 220114, Republic of Belarus

Республика Беларусь, 220114 Минск, ул. Ф. Скорины, 24

Belarusian Medical Academy of Postgraduate EducationБелорусская медицинская академия последипломного образованияRepublican Research and Clinical center of Neurology and NeurosurgeryРеспубликанский научно-практический центр неврологии и нейрохирургии1501201712147550704201707042017Copyright ©; 2017, ABV-PressCopyright ©; 2017, АБВ-пресс2017ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/193

Some issues concerning the impact of hypothalamic-pituitary-adrenal system (HPAS) hormones on epileptogenesis are discussed in the article. It was found, that they have a direct and indirect impact. Direct effect implies the reduction of excitation level in the brain cells by affecting membrane channels and receptors involved in the regulation of certain neurotransmitters synthesis. Indirect effect is realized through positive influence on the brain neurons maturation process, leveling the stimulation of excitation processes mediated by biologically active substances, ions and other agents. Adrenocorticotropic hormone and glucocorticosteroids are the main hormones used in antiepileptic therapy. They have an impact both on epileptogenesis itself, and on induction/inhibition of their own effects in accordance with a feedback mechanism of hormones secretion. The mechanism of antiepileptic action of HPAS hormones allows considering them as true antiepileptic drugs for treatment of drug-resistant and special forms of epilepsy.

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