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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Child Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Child Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Русский журнал детской неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-8803</issn><issn publication-format="electronic">2412-9178</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">19</article-id><article-id pub-id-type="doi">10.17650/2073-8803-2014-9-2-30-31</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">THE PROBLEM OF AGGRAVATION OF EPILEPTIC SEIZURES DURING THERAPY WITH ANTIEPILEPTIC DRUGS</article-title><trans-title-group xml:lang="ru"><trans-title>К проблеме аггравации эпилептических приступов на фоне терапии антиэпилептическими препаратами</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mukhin</surname><given-names>K. Yu.</given-names></name><name xml:lang="ru"><surname>Мухин</surname><given-names>К. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>center@epileptologist.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pylaeva</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Пылаева</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Saint Luka’s Institute of Child Neurology and Epilepsy, Moscow</institution></aff><aff><institution xml:lang="ru">ООО «Институт детской неврологии и эпилепсии им. Святителя Луки», Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2014</year></pub-date><volume>9</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>30</fpage><lpage>31</lpage><history><date date-type="received" iso-8601-date="2015-04-18"><day>18</day><month>04</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-04-18"><day>18</day><month>04</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, АБВ-пресс</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://rjdn.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://rjdn.abvpress.ru/jour/article/view/19">https://rjdn.abvpress.ru/jour/article/view/19</self-uri><abstract xml:lang="en"><p>The paper gives a brief literature review coming to the attention of practitioners to the problem of aggravation in epilepsy. Despite the fact that the purpose of use of antiepileptic drugs is to stop seizures and to suppress epileptic activity on electroencephalogram; in some cases their administration may worsen epilepsy, namely may make seizures more frequent and severer (may cause aggravation). Status epilepticus is the severest manifestation of aggravation. The drugs differ in the risk of aggravation, which also depends on the type of seizures and patient age.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен краткий обзор литературы, привлекающий внимание практических врачей к проблеме аггравации при эпилепсии. Несмотря на то, что цель применения антиэпилептических препаратов – прекращение приступов и подавление эпилептической активности на электроэнцефалограмме, в некоторых случаях их применение может вызывать ухудшение течения эпилепсии – учащение и утяжеление приступов (аггравация). Эпилептический статус – наиболее тяжелое проявление аггравации. Препараты отличаются по риску аггравации, который также зависит от типа приступов и возраста пациента.</p></trans-abstract><kwd-group xml:lang="en"><kwd>epilepsy</kwd><kwd>antiepileptic drugs</kwd><kwd>aggravation</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>эпилепсия</kwd><kwd>антиэпилептические препараты</kwd><kwd>аггравация</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин. М.: Медицина, 2010. 717 с.</mixed-citation><mixed-citation xml:lang="ru">Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин. М.: Медицина, 2010. 717 с.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Карлов В.А., Овнатанов Б.С. Медиобазальные эпилептические очаги и абасансная активность на ЭЭГ. Журн неврол психиатр им. С.С. 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