Russian Journal of Child NeurologyRussian Journal of Child NeurologyРусский журнал детской неврологии2073-88032412-9178Publishing House ABV Press18510.17650/2073-8803-2016-11-4-54-60CLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯEFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICEЭффективность руфинамида в лечении фармакорезистентной фокальной эпилепсии в педиатрической практикеShchederkinaI. O.ЩедеркинаИ. О.
Russian Federation

1/9 4th Dobryninskiy Pereulok, Moscow 119049;

1 Ostrovityanova St., Moscow, 117997

119049 Москва, 4-й Добрынинский переулок, 1/9;

117997 Москва, ул. Островитянова, 1

schederkina@bk.ruOrlovaK. A.ОрловаК. А.
Russian Federation

1/9 4th Dobryninskiy Pereulok, Moscow 119049;

1 Ostrovityanova St., Moscow, 117997

119049 Москва, 4-й Добрынинский переулок, 1/9;

117997 Москва, ул. Островитянова, 1

KoltunovI. E.КолтуновИ. Е.
Russian Federation

1/9 4th Dobryninskiy Pereulok, Moscow 119049;

6 Miklukho-Maklaya St., Moscow 117198

119049 Москва, 4-й Добрынинский переулок, 1/9;

117198 Москва, ул. Миклухо-Маклая, 6

DorofeevaM. Yu.ДорофееваМ. Ю.
Russian Federation

2 Taldomskaya St., Moscow 125412

125412 Москва, ул. Талдомская, 2

Morozov Children’s City Clinical Hospital, Moscow Healthcare DepartmentГБУЗ «Морозовская детская городская клиническая больница Департамента здравоохранения г. Москвы»N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииPeoples’ Friendship University of RussiaФГАОУ ВО «Российский университет дружбы народов»Acad. Yu.E. Vel’tishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России1512201611454602802201728022017Copyright ©; 2016, ABV-PressCopyright ©; 2016, АБВ-пресс2016ABV-PressАБВ-прессhttps://rjdn.abvpress.ru/jour/about/editorialPolicieshttps://rjdn.abvpress.ru/jour/article/view/185

Among drug-resistant epilepsies, epileptic syndromes, characterized by combination of several types of seizures, are considered to be the most difficult in terms of treatment. Lennox–Gastaut syndrome is one of them. It manifests with polymorphic seizures (tonic axial, myatonic, atypical absence seizures, status epilepticus of minor motor seizures, myoclonic, generalized convulsive, and focal seizures). This is a heterogeneous disease, represented by a complex of clinical and electroencephalographic manifestations with various etiology. Current review is devoted to a novel antiepileptic drug rufinamide, which has a new mechanism of action. The drug has been registered in Russia in 2015. The authors also describe their own experience of rufinamide usage in the treatment of drug-resistant focal epilepsy as a part of multicomponent therapy for polymorphic seizures. One patient achieved clinical remission for 16 months; the second one had more than 50 % decrease in seizures frequency with a remission of drop-attacks.

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